Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

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Liujunzi Decoction Regulated Intestinal Flora Homeostasis to Relieve Lung–Gut Axis Inflammation in Asthma Flora Disorder Mice: Possibly Related to GATA3/ILC2

Chinese Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Language: Английский

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The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 488 - 488

Published: May 10, 2025

Background/Objectives: Antibiotics have a significant impact on the gut microbiota, and we hypothesized that human milk oligosaccharides may alleviate antibiotic-induced microbiota dysbiosis. Methods: Six groups of eight mice were administered drinking water with or without ampicillin for one week. We then introduced oligosaccharide 2′-fucosyllactose (2′FL), either alone in combination difucosyl-lactose (DFL), two weeks after termination treatment. Results: Ampicillin reduced diversity abundance specific bacteria. One week treatment, 2′FL + DFL mixture counteracted ampicillin-induced reduction diversity, although this effect was not sustained. Over subsequent weeks, had relative abundances Lactobacillus spp. Bacteroides also caecal propionate levels, downregulated gene Gzmb Granzyme B, upregulated Reg3a Regenerating islet-derived protein 3 alpha, all which by mixture. minor ileal cytokine levels. The showed indicating adaptive innate inflammation. intake growth mice. did affect intake, but slightly body weight. Conclusions: appears to hold potential counteracting some side effects

Language: Английский

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Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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