Alcohol Consumption and Autoimmune Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 845 - 845

Published: Jan. 20, 2025

Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths associated with significant behavioral, social, economic difficulties. As alcohol consumption may modulate immune system’s regulatory mechanisms to avoid attacking body’s tissues, it proven play dichotomic role autoimmune (ADs) based on quantity consumption. In this review, we report updated evidence ADs, focus addiction human biological system relationship between them, risk or protective factor. Then, narrative main most studied ADs where represents key modulator, including thyroiditis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, diabetes, allergic rhinitis, primary biliary cholangitis. at low–moderate dosages seems mostly have these diseases, while higher dosages, collateral risks surpass possible benefits. The specific by which low-to-moderate intake relieves AD symptoms are not yet fully understood; however, emerging studies suggest that immunomodulatory effect, potentially altering balance anti-inflammatory innate adaptive cells, well cytokines (via NF-κB NLRP3 pathways). might influence composition gut microbiome (increasing amounts beneficial microbes) production their fatty acid metabolites, such short-chain acids (SCFAs) polyunsaturated (PUFAs), elevated concentrations acetate, high-density lipoprotein (HDL), nitric oxide (NO). Unfortunately, definite acceptable daily (ADI) ethanol complicated establish because many despite interesting content findings, there limit applicability should be weighed cases alcoholic drinking recommendations. aim future those pathways involved alcohol-protective various strategies intake.

Language: Английский

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Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 11, 2025

Language: Английский

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Gut microbiome alterations in immune thrombocytopenia: a systematic review of current evidence

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 16, 2025

Background Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction and impaired production. Recent evidence suggests a role for gut microbiome dysbiosis in diseases, but its association with ITP remains unclear. This systematic review explores the potential link between pathophysiology. Methods We conducted comprehensive search five databases (MEDLINE, Scopus, Web of Science, Cochrane Library, Embase) from 1980 to July 2024, adhering PRISMA 2020 guidelines. Studies assessing patients were included. The primary outcome was alterations microbiota composition, study selection performed three phases, discrepancies resolved through consensus. Results From 480 studies screened, 12 met inclusion criteria. revealed significant particularly at phylum level. An increase Bacteroidetes Proteobacteria observed some studies, while others reported decrease these phyla. Firmicutes showed inconsistent results across studies. Alpha beta diversity analysis also yielded conflicting results, reporting decreased diversity, found no difference or increase. Conclusion suggest ITP, though findings remain Further well-designed research needed clarify implications novel therapeutic approaches.

Language: Английский

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Autoimmunity and the microbiome

Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 4 - 8

Published: July 9, 2024

Language: Английский

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The Gut Microbiome and Autoimmunity

Inside Precision Medicine, Journal Year: 2024, Volume and Issue: 11(5), P. 12 - 15

Published: Oct. 1, 2024

Language: Английский

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