Mutual Interactions Between Microbiota and the Human Immune System During the First 1000 Days of Life

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 299 - 299

Published: March 16, 2025

The development of the human immune system starts during fetal period in a largely, but probably not completely, sterile environment. During and after birth, is exposed to an increasingly complex microbiota. first microbiota encountered passage through birth canal colonize infant gut induce tolerance system. Transplacentally derived maternal IgG as well IgA from breast milk protect infections 100 days, which further develops immunological memory formed. Weaning introduction solid food expose novel (food) antigens allow for other colonize. cells molecules involved mutual intricate interactions between developing are now beginning be recognized. These include bacterial components such polysaccharide A Bacteroides fragilis, metabolites short-chain fatty acid butyrate, indole-3-aldehyde, indole-3-propionic acid. All these, more, have specific immunoregulatory functions shape 1000 days life.

Language: Английский

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Antibodies in breast milk: Pro‐bodies designed for healthy newborn development

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

This manuscript sheds light on the impact of maternal breast milk antibodies infant health. Milk prepare and protect newborn against environmental exposure, guide regulate offspring's immune system, promote transgenerational adaptation system to its environment. While transfer IgG across placenta ceases at birth, are continuously replenished by system. They reflect mother's real-time environment which is exposed. cover infant's upper respiratory digestive mucosa perfectly positioned control responses antigens might also reach their circulation. Maternal in play a key role defense developing child, with major infectious disease susceptibility both HIC LMIC. influence development another health burden children-allergies. Finally, emerging evidence shows that actively shape development. Much this likely be mediated effect seeding, composition function microbiota, but not only. Further understanding bridge provide between child should enable best interventions healthy

Language: Английский

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Immune responses to food

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

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