Dietary arachidonic acid contributes to alleviation of peanut-induced allergy biomarkers in BALB/c, C57BL/6 and CD-1 mice DOI

A. A. M. El-Gendy,

Hatem Tallima

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113661 - 113661

Published: Nov. 26, 2024

Language: Английский

Oral Immunotherapy with Standardized Peanut Extract: A Game-Changer for Peanut Allergy DOI Creative Commons

Edoardo Cavaglià,

G. Valentini,

Nicolò Valli

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(9), P. 4833 - 4833

Published: April 27, 2025

Peanut allergy is a persistent and potentially life-threatening condition affecting millions worldwide, necessitating effective therapeutic strategies beyond strict avoidance. Oral immunotherapy (OIT) has emerged as promising approach, with peanut (Arachis hypogaea) allergen powder dnfp (Palforzia Aimmune therapeutics Brisbane Calif]) being the first FDA-approved standardized OIT for allergy. This review synthesizes current clinical evidence on PTAH (peanut-tolerant Arachis hypogea), focusing its efficacy, safety, long-term outcomes. A systematic literature search was conducted, analyzing key phase 3 trials, including PALISADE, ARTEMIS, POSEIDON, well extension studies such ARC004 ARC008. Findings indicate that significantly increases protein threshold tolerated by allergic individuals, reducing risk of severe reactions upon accidental exposure. While adverse events gastrointestinal symptoms anaphylaxis occur, they are generally manageable decline over time continued therapy. Notably, younger children in POSEIDON trial exhibited higher desensitization rates, suggesting potential benefits early intervention. Long-term demonstrate sustained immune modulation, reductions peanut-specific IgE an increase IgG4, indicative developing tolerance. Despite limitations adherence challenges need ongoing maintenance dosing, represents paradigm shift management, offering improved safety quality life patients caregivers.

Language: Английский

Citations

0
Fundamentals of laboratory diagnostics in allergology DOI Creative Commons

Christos Arsenis,

Styliani Τaka, Chrysanthi Skevaki

et al.

Allergo Journal International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Grundlagen der Labordiagnostik in der Allergologie DOI

Christos Arsenis,

Styliani Τaka, Chrysanthi Skevaki

et al.

Allergo Journal, Journal Year: 2025, Volume and Issue: 34(2), P. 16 - 29

Published: March 1, 2025

Citations

0
Dietary arachidonic acid contributes to alleviation of peanut-induced allergy biomarkers in BALB/c, C57BL/6 and CD-1 mice DOI

A. A. M. El-Gendy,

Hatem Tallima

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113661 - 113661

Published: Nov. 26, 2024

Language: Английский

Citations

0