Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy DOI Creative Commons

Weiran Wang,

Xiang Fu,

Bolin Gu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104601 - 104601

Published: Nov. 27, 2024

Language: Английский

Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

Citations

0
Innate Immune Sensors in Health and Disease DOI Open Access
Prajwal Gurung

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Peptide-Modified Mesoporous Silica Nanoparticles for the Coordinated Regulation of Macrophage Polarization and Pyroptosis in the Treatment of Implant-Related Infections DOI Creative Commons
Zhi Li, Yuhang Wang,

Xingshi Yuan

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101629 - 101629

Published: March 4, 2025

Implant-related infections (IRIs) present a significant challenge in clinical treatment because of the formation biofilms. The complex architecture biofilms not only impedes antibiotic penetration, fostering evolution multidrug resistance bacteria under minimal selective pressure but also suppresses antimicrobial activity macrophages and induces their pyroptosis large quantities. This excessive impairs collective immune function macrophages, enabling pathogens to evade system clearance rendering infection difficult eradicate. Existing strategies often necessitate extensive surgical debridement, which causes harm patients' physiological health quality life results limited therapeutic outcomes. To address these challenges, this study developed mesoporous silica nanoparticle (MRL) modified with RGD (Arginine-Glycine-Aspartic acid) tripeptide loaded peptide LL-37. LL-37 released from MRL can directly disrupt bacterial cell membranes, preventing developing through conventional mutation mechanisms, enhance by modulating macrophage polarization toward M1 phenotype. However, may induce exacerbate within Therefore, we nanoparticles increase viability reduce number deaths, thereby alleviating immunosuppression caused pyroptosis. In vitro vivo experiments demonstrated that MRL, while preserving immunomodulatory LL-37, significantly reduced protected macrophages. Thus, fine-tuned regulation response was achieved, providing new insights for IRIs.

Language: Английский

Citations

0
Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease DOI
Yuting Jiang, Jie Chen,

Yaoyao Du

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114462 - 114462

Published: April 7, 2025

Language: Английский

Citations

0
Triggering Pyroptosis in Cancer DOI Creative Commons

Daniel E. Johnson,

Zhibin Cui

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 348 - 348

Published: Feb. 28, 2025

Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of death, canonical pyroptosis involves the specific cleavage gasdermin by caspase-1, resulting membrane damage and release pro-inflammatory cytokines IL-1β IL-18. Initially observed innate immune cells responding to external pathogens or internal signals, pyroptotic has now been numerous types. Recent studies have extensively explored different ways trigger solid tumors, presenting promising avenue for cancer treatment. This review outlines mechanisms both noncanonical pertinent primarily focuses on biomolecules that can induce malignancies. strategy aims not only eliminate but also promote improved tumor microenvironment. Furthermore, emerging research indicates targeting pathways may improve effectiveness existing treatments, making them more potent against resistant types, offering new hope overcoming treatment resistance aggressive

Language: Английский

Citations

0
Controlling pyroptosis through post-translational modifications of gasdermin D DOI
Na Zhang, Daichao Xu

Developmental Cell, Journal Year: 2025, Volume and Issue: 60(7), P. 994 - 1007

Published: April 1, 2025

Language: Английский

Citations

0
Molecular characterization and functional analysis of IL-18 in large yellow croaker (Larimichthys crocea) DOI
Yongyang Wang, Jiajia Ye, Y. Luo

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110398 - 110398

Published: May 1, 2025

Language: Английский

Citations

0
Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy DOI Creative Commons

Weiran Wang,

Xiang Fu,

Bolin Gu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104601 - 104601

Published: Nov. 27, 2024

Language: Английский

Citations

0