Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta‐analysis

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(2)

Published: Feb. 1, 2024

Abstract Postoperative wound infections (PWIs) pose a significant challenge in colorectal cancer surgeries, leading to prolonged hospital stays and increased morbidity. This systematic review meta‐analysis evaluated the efficacy of traditional Chinese medicine (TCM) combination Jie Geng Huang Qi reducing PWIs following surgeries. Adhering PRISMA guidelines, we focused on seven randomized controlled trials (RCTs) involving 1256 patients, examining incidence within 30 days post‐surgery, alongside secondary outcomes such as length stay antibiotic use. The analysis revealed reduction PWI TCM‐treated group compared controls, with Risk Ratio 0.21 (95% CI: 0.14 0.30, p < 0.01), notable decrease (Mean Difference: 1.2 days, 95% 0.15 1.28 0.01) use (Risk Ratio: 0.24, 0.16 0.36, 0.01). These findings suggest that TCM could be an effective adjunct postoperative care for underscoring need further high‐quality RCTs substantiate these results explore underlying mechanisms.

Language: Английский

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Construction and Development of an Enhanced Recovery After Surgery Program for the Surgical Management of Patients With Spinal Metastasis: A Modified Delphi Study

Orthopaedic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

As an effective treatment for spinal metastasis (SM), ERAS protocol can significantly reduce the length of hospital stay and complications in patients. Establishing program perioperative care after SM surgery is a clinical problem that needs to be addressed urgently. We aimed develop Enhanced Recovery After Surgery (ERAS) Surgical Safety Checklist (SSC) conferred benefit patients with made it relatively easy manage condition. believe our findings could help establish promote continuous improvement additional programs SM. This modified Delphi study. used two-round process using data acquired from review relevant literature involving multidisciplinary panel experts different hospitals China. The survey was conducted February 1, 2024 April 20, 2024. were invited evaluate each current recommended topics determine appropriateness inclusion SSC 5-point Likert scale. Used results create specific (70% consensus) programs. Close consensus (65%-69% considered follow-up survey. A multicenter, group physicians (n = 75), including workers, researchers, anesthesiologists, nursing specialists, psychologists, nutritionists, caregivers, experience managing SM, asked participate. Using process, we arrived at program. included 37 consolidated items domains following order: preoperative, intraoperative, postoperative, discharge. before induction anesthesia, skin incision, patient leaves operating room. study, based on helped us SCC consensus-driven best practice recommendations, suggestions related surgery, hope this which integrated both traditional Chinese Western medical protocols, provide basis rapid rehabilitation surgical interventions

Language: Английский

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The Wnt/β-catenin signaling pathway in colorectal cancer: mechanism and intervention of traditional Chinese medicine and chemical compound

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Colorectal cancer (CRC) is globally recognized as the third most frequently diagnosed malignancy and second leading cause of cancer-related mortality. The etiology CRC multifactorial, arising from a complex interplay genetic alterations, environmental exposures, age-related physiological changes. Among numerous signaling pathways that regulate cellular homeostasis, Wnt/β-catenin pathway not only plays critical role in embryonic development cell proliferation but also contributes to initiation progression various malignancies, including CRC. Dysregulation hallmark CRC, playing pivotal regulating chemoresistance driving invasive metastatic behaviors. Traditional Chinese Medicine (TCM) characterized by its multi-target multi-pathway mechanisms. Extensive studies have demonstrated TCM can inhibit activity cells targeting significantly alleviate symptoms animal models, demonstrating potential therapeutic value for treatment This review primarily focuses on literature published past 5 years, retrieved databases such PubMed, Web Science, Scopus, MEDLINE, Springer, concerning It highlights research progress monomers (e.g., myricetin, genistein, baicalein), formulations Pai-Nong-San (PNS), Jian-Du-Xiao-Sheng Yin (JXY), Zuo-Jin-Wan (ZJW)), small-molecule inhibitors PCDHGA9, Cetuximab, PTK7). Furthermore, experimental results conclusions these are thoroughly analyzed discussed. Through comprehensive literature, we conclude exhibits multi-level, multi-target, multi-faceted effects prevention In-depth into mechanisms which targets prevent treat may provide novel insights exploring pathogenesis developing new agents

Language: Английский

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Research progress on the influence of traditional Chinese medicine on tumor microenvironment therapy

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

More and more attention has been paid to the tumor microenvironment. The occurrence, development, metastasis, drug resistance of are closely related At same time, application traditional Chinese medicine (TCM) in prevention treatment attracted due its regulatory effect on cells holistic view multitarget TCM make it very suitable for regulation This article will review current research status molecular mechanism microenvironment from three aspects: can reverse inhibitory phenotype immune cells, enhance response clinical application.

Language: Английский

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