Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 27, 2025

Abstract Introduction Previous studies highlighted the association between triglyceride–glucose (TyG) index and cardiovascular events in patients with diabetes. However, whether diabetes affects TyG-cardiovascular diseases (CVD) is still unclear. This study aimed to evaluate TyG CVD risk, stratified by status, as well potential modifying effect of diabetic status. Methods/design The PubMed, Cochrane Library, Embase databases were searched for on associations mortality without from inception December 2, 2024. random effects model was employed pool sizes. Results A total 50 cohort (7,239,790 participants) included. mean age participants 31.46 years (diabetes mellitus [DM]: 65.18; non-DM: 31.23), 40.66% female (DM: 36.07%; 40.70%). (HR: 1.72 vs. 1.55, P = 0.55), major adverse cerebrovascular 2.02 1.91, 0.84), stroke 1.46 1.39, 0.77) death 1.85 1.60, 0.56) similar among DM non-DM individuals. ischemic heart disease (IHD) 2.20 1.57, 0.03) all-cause 1.94 1.24, 0.01) stronger than patients. Conclusion showed events, mortality, independent low moderate certainty. IHD individuals Future should explore role index-associated outcomes mortality. Graphical abstract

Language: Английский

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The triglyceride glucose index as a sensitive predictor for the risk of MACCEs in patients with diabetic foot ulcers: An ambispective longitudinal cohort study

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(4)

Published: April 1, 2024

Abstract The triglyceride glucose (TyG) index has been confirmed a predictive value for type 2 diabetes mellitus (T2DM). However, no research yet whether there is linear correlation between the TyG and MACCEs in DFUs. present study aimed to delve into association risk of patients with A total 960 inpatients DFUs were recruited. All participants followed up every 6 months 11 years median 83 months. According cut‐off acquired from receiver operating characteristic (ROC) analysis, subjects divided two groups: low‐level (<9.12, n = 480) high‐level (≥9.12, 480). relationship was evaluated by multivariable Cox regression model, restricted cubic spline (RCS) stratified analysis Kaplan–Meier survival analysis. Out participants, 271 experienced (28.22%), whom 79 (29.15%) died. ROC got optimal 9.12. Multivariable combined RCS model showed that positively associated an S‐shaped non‐linear dose‐dependent manner within range 7.5–9.5 ( p < 0.001). indicated higher index, greater cumulative incidence (log‐rank, first positive Consequently, lowering level aids improving prognosis

Language: Английский

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The Monocyte-to-High-Density Lipoprotein Cholesterol Ratio as a Novel Predictor of the Prevalence of Senile Osteoporosis

Clinical Interventions in Aging, Journal Year: 2024, Volume and Issue: Volume 19, P. 1773 - 1788

Published: Nov. 1, 2024

The prevalence of osteoporosis in elderly individuals is high, and strongly associated with chronic inflammation. monocyte-to-high-density lipoprotein ratio (MHR) acknowledged as a marker for assessing systemic inflammation oxidative stress, changes the MHR are many disease prevalent among population. This study investigated relationships between incidence older adults, along its predictive value.

Language: Английский

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Evaluation of Cardiovascular Disease Risk in Patients with Type 2 Diabetes Mellitus Using Clinical Laboratory Markers

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3561 - 3561

Published: June 18, 2024

Background: Cardiovascular diseases (CVD) are the main cause of death in population with diabetes mellitus. This study purposed to determine clinical laboratory markers that might be correlated risk CVD individuals type 2 mellitus (T2DM). Methods: Using data from Clinical Center University Debrecen 2016 2020, we assessed cardiovascular 5593 T2DM over a five-year follow-up period. There were 347 new cases acute myocardial infarction (AMI) and stroke during Following stratification these into two groups according diagnosis CVDs until was through utilization Chi-square test Cox proportional hazards regression. Results: The findings regression model showed number HbA1C measurements per year (HR = 0.46, 95% CI 0.31-0.7), decreased levels estimated glomerular filtration rate (eGFR) 1.6, 1.04-2.47), elevated triglyceride 1.56, 1.06-2.29) patients T2DM. area under curve (AUC) increased 0.557 (95% 0.531-0.582) 0.628 0.584-0.671) after inclusion variables showing improved discrimination for AMI stroke. Conclusions: These indicated eGFR, triglyceride,

Language: Английский

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Red cell distribution width/albumin ratio as a marker for metabolic syndrome: findings from a cross-sectional study

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 25, 2024

Metabolic syndrome (MetS) imposes a significant health burden on patients globally. Chronic low-grade inflammation is pivotal in the onset and progression of this condition. However, role novel inflammatory marker, red cell distribution width to albumin ratio (RAR), development MetS remains unclear. This population-based cross-sectional study utilized data from 2011–2020 National Health Nutrition Examination Survey (NHANES). Participants included individuals over 18 years old with complete serum concentration, distribution, its components. was defined using criteria established by Cholesterol Education Program Adult Treatment Panel III. The calculation formula for RAR is: = Red (%)/serum (g/dL). Study participants were stratified into four quartiles based levels. Logistic regression analysis subgroup employed explore independent interaction between MetS, as well investigate relationship levels specific components MetS. Finally, receiver operating characteristic (ROC) curve used assess predictive efficacy A total 4899 study, comprising 2450 males 2449 females; 1715 (35.01%) diagnosed As quartile increased, proportion also increased. Spearman correlation indicated positive insulin resistance index HOMA-IR. analysis, adjusting multiple confounding factors, showed that each standard deviation increase associated 1.665-fold (95% CI, 1.404–1.975; P < 0.001) odds prevalence. In logistic RAR, risks Q1-Q4 1.372 1.105–1.704; 0.004), 1.783 1.434–2.216; 0.001), 2.173 1.729–2.732; respectively. Subgroup analyses tests demonstrated gender, age, race, education, smoking status, physical activity modified association (p 0.05). Additionally, area under optimal cutoff value predicting 3.1348 (sensitivity: 59.9%; specificity: 60.6%; AUC: 0.628). Increasing are higher risk Therefore, greater attention should be given high improved prevention treatment

Language: Английский

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The Impact of Triglyceride-Glucose (TyG) Index on Future Cardio and Cerebrovascular Events in Patients with Acute Coronary Syndrome, During 3 Years of Follow-Up

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(11), P. 354 - 354

Published: Nov. 5, 2024

The triglyceride-glucose (TyG) index is a new alternative insulin resistance (IR) biomarker. purpose of this study was to assess whether the TyG can have prognostic value in patients with acute coronary syndrome (ACS). Moreover, we wanted compare HOMA index.

Language: Английский

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