Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward DOI Creative Commons
Viviana Trezza,

Ruth Damsteegt,

E. J. Marijke Achterberg

et al.

Journal of Neuroscience, Journal Year: 2011, Volume and Issue: 31(17), P. 6362 - 6370

Published: April 27, 2011

Positive social interactions are essential for emotional well-being and proper behavioral development of young individuals. Here, we studied the neural underpinnings reward by investigating involvement opioid neurotransmission in nucleus accumbens (NAc) play behavior, a highly rewarding interaction adolescent rats. Intra-NAc infusion morphine (0.05–0.1 μg) increased pinning pouncing, characteristic elements behavior rats, blockade NAc receptors with naloxone (0.5 prevented play-enhancing effects systemic (1 mg/kg, s.c.) administration. Thus, stimulation was necessary sufficient to increase play. treatment selective μ-opioid receptor agonist [ d -Ala 2 , N -MePhe 4 ,Gly 5 -ol]enkephalin (DAMGO) (0.1–10 ng) antagonist Cys-Tyr- -Trp-Arg-Thr-Pen-Thr-NH (CTAP) (0.3–3 decreased play, respectively. The δ-opioid DPDPE ([ -Pen ]-enkephalin) had no effects, whereas κ-opioid U69593 ( -methyl-2-phenyl- -[(5 R ,7 S ,8 )-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide) (0.01–1 β-endorphin but met-enkephalin (0.1–5 enkephalinase inhibitor thiorphan (0.1–1 were ineffective. DAMGO after into both shell core subregions NAc. Last, intra-NAc CTAP (3 play-induced conditioned place preference. These findings identify as an important mechanism attribution positive value Altered function may underlie impairments psychiatric disorders such autism, schizophrenia, or personality disorders.

Language: Английский

The glutamate homeostasis hypothesis of addiction DOI
Peter W. Kalivas

Nature reviews. Neuroscience, Journal Year: 2009, Volume and Issue: 10(8), P. 561 - 572

Published: July 1, 2009

Language: Английский

Citations

1282
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning DOI Open Access
Hsing-Chen Tsai, Feng Zhang, Antoine Adamantidis

et al.

Science, Journal Year: 2009, Volume and Issue: 324(5930), P. 1080 - 1084

Published: April 24, 2009

Rewarding Bursts of Dopamine Dopaminergic neurons are thought to be involved in the cognitive and hedonic underpinnings motivated behaviors. However, it is still unclear whether dopaminergic neuron activation sufficient elicit reward-related behavior which type neuronal activity pattern serves this purpose. Tsai et al. (p. 1080; published online 23 April) directly compared tonic versus phasic firing cells ventral tegmental area, effects on both dopamine release. Using a transgenic system virus injection mice, they targeted with rhodopsin. Light stimulation was then used drive either low level pulses or bursts high-frequency pulses, number being equal across conditions. Only induced conditioned place preference

Language: Английский

Citations

1239
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin DOI
Gül Dölen, Ayeh Darvishzadeh, Kee Wui Huang

et al.

Nature, Journal Year: 2013, Volume and Issue: 501(7466), P. 179 - 184

Published: Sept. 1, 2013

Language: Английский

Citations

1075
Reward Processing by the Opioid System in the Brain DOI
Julie Le Merrer, Jérôme A. J. Becker, Katia Befort

et al.

Physiological Reviews, Journal Year: 2009, Volume and Issue: 89(4), P. 1379 - 1412

Published: Sept. 29, 2009

The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous peptides processed from protein precursors, proopiomelanocortin, proenkephalin, prodynorphin. Opioid receptors recruited in response to natural rewarding stimuli drugs abuse, both opioids their modified as addiction develops. Mechanisms whereby aberrant activation modifications the contribute drug craving relapse remain be clarified. This review summarizes our present knowledge on brain sites where controls hedonic responses is abuse rodent brain. We 1) latest data anatomy system, 2) consequences local intracerebral pharmacological manipulation reinforced behaviors, 3) gene knockout behaviors dependence, 4) chronic exposure expression levels genes. Future studies will establish key molecular actors neural onset addictive disorders. Combined with human nonhuman primate (not reviewed here), research this extremely active field has implications for understanding biology therapeutic interventions treat disorder.

Language: Английский

Citations

942
Discriminative and Affective Touch: Sensing and Feeling DOI Creative Commons
Francis McGlone, Johan Wessberg, Håkan Olausson

et al.

Neuron, Journal Year: 2014, Volume and Issue: 82(4), P. 737 - 755

Published: May 1, 2014

Language: Английский

Citations

918
Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior DOI
Rainer Spanagel

Physiological Reviews, Journal Year: 2009, Volume and Issue: 89(2), P. 649 - 705

Published: April 1, 2009

Alcohol consumption is an integral part of daily life in many societies. The benefits associated with the production, sale, and use alcoholic beverages come at enormous cost to these World Health Organization ranks alcohol as one primary causes global burden disease industrialized countries. Alcohol-related diseases, especially alcoholism, are result cumulative responses exposure, genetic make-up individual, environmental perturbations over time. This complex gene × environment interaction, which has be seen a life-span perspective, leads large heterogeneity among alcohol-dependent patients, terms both symptom dimensions severity this disorder. Therefore, reductionistic approach not very practical if better understanding pathological processes leading addictive behavior achieved. Instead, systems-oriented perspective interactions dynamics all endogenous factors involved centrally integrated, will lead further progress research. review adheres systems biology such that interaction secondary targets within brain described relation behavioral consequences. As targets, alterations expression synaptic plasticity take place long-lasting alteration neuronal network activity. subsequent consequence, alcohol-seeking ensue can finally via behavior.

Language: Английский

Citations

628
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior DOI Creative Commons
Takatoshi Hikida,

Kensuke Kimura,

Norio Wada

et al.

Neuron, Journal Year: 2010, Volume and Issue: 66(6), P. 896 - 907

Published: June 1, 2010

Language: Английский

Citations

576
Neuropharmacology of alcohol addiction DOI
Valentina Vengeliene, Ainhoa Bilbao,

Anna Molander

et al.

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 299 - 315

Published: March 3, 2008

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent molecular pharmacology studies demonstrated has only a few known primary targets. These are NMDA, GABA(A), glycine, 5-hydroxytryptamine 3 (serotonin) and nicotinic ACh receptors as well L-type Ca(2+) channels G-protein-activated inwardly rectifying K(+) channels. Following this first hit of on specific targets in brain, second wave indirect effects variety neurotransmitter/neuropeptide systems initiated leads subsequently to typical acute behavioural alcohol, ranging from disinhibition sedation even hypnosis, with increasing concentrations alcohol. Besides these pharmacodynamic aspects we discuss neurochemical substrates involved initiation maintenance phase drinking behaviour. Finally, addictive behaviour towards measured by alcohol-seeking relapse reviewed context their signalling pathways. The activity mesolimbic dopaminergic system plays crucial role during consumption. long-term, chronic consumption virtually all brain neurotransmission seems be affected, making it difficult define which contributes most transition controlled compulsive use. However, characterized decrease function reward neurocircuitry recruitment antireward/stress mechanisms comes into place, hypertrophic corticotropin-releasing factor hyperfunctional glutamatergic being important ones.

Language: Английский

Citations

562
Rodent models in neuroscience research: is it a rat race? DOI Creative Commons
Bart Ellenbroek, Jiun Youn

Disease Models & Mechanisms, Journal Year: 2016, Volume and Issue: 9(10), P. 1079 - 1087

Published: Oct. 1, 2016

ABSTRACT Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over last two decades, with mice taking a more prominent role science compared to rats. This was primarily instigated by availability of much larger genetic toolbox mice, particularly embryonic-stem-cell-based targeting technology gene disruption. With recent emergence tools altering rat genome, notably genome-editing technologies, technological gap between organisms is closing, it becoming important consider physiological, anatomical, biochemical pharmacological differences rats when choosing right model system specific biological question. The aim this short review accompanying poster highlight some differences, discuss their impact on studies human diseases, special focus neuropsychiatric disorders.

Language: Английский

Citations

538
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis DOI Open Access
Michael D. Scofield, Jasper A. Heinsbroek, Cassandra D. Gipson

et al.

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(3), P. 816 - 871

Published: June 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Language: Английский

Citations

529