Regulation of antioxidant enzymes: a significant role for melatonin

Journal of Pineal Research, Journal Year: 2003, Volume and Issue: 36(1), P. 1 - 9

Published: Dec. 11, 2003

Abstract: Antioxidant enzymes form the first line of defense against free radicals in organisms. Their regulation depends mainly on oxidant status cell, given that oxidants are their principal modulators. However, other factors have been reported to increase antioxidant enzyme activity and/or gene expression. During last decade, melatonin has shown possess genomic actions, regulating expression several genes. Melatonin also influences both and cellular mRNA levels for these enzymes. In present report, we review studies which document influence antioxidative glutathione peroxidase, superoxide dismutases catalase under physiological conditions elevated oxidative stress. We analyze possible mechanisms by regulates

Language: Английский

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Melatonin as a natural ally against oxidative stress: a physicochemical examination

Journal of Pineal Research, Journal Year: 2011, Volume and Issue: 51(1), P. 1 - 16

Published: June 14, 2011

Abstract: Oxidative stress has been proven to be related the onset of a large number health disorders. This chemical is triggered by an excess free radicals, which are generated in cells because wide variety exogenous and endogenous processes. Therefore, finding strategies for efficiently detoxifying radicals become subject great interest, from both academic practical points view. Melatonin ubiquitous versatile molecule that exhibits most desirable characteristics good antioxidant. The amount data gathered so far regarding protective action melatonin against oxidative overwhelming. However, rather little known concerning mechanisms involved this activity. review summarizes current progress understanding physicochemical insights radical–scavenging activity melatonin. Thus far, there general agreement electron transfer hydrogen main reactions with radicals. relative importance other also analyzed. nature reacting radical influence on different these reactions. point discussed detail review. Based available data, it concluded protects mechanisms. Moreover, proposed even though referred as expression darkness, perhaps could light health.

Language: Английский

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Melatonin—A pleiotropic, orchestrating regulator molecule

Progress in Neurobiology, Journal Year: 2010, Volume and Issue: 93(3), P. 350 - 384

Published: Dec. 29, 2010

Language: Английский

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Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Endocrine, Journal Year: 2005, Volume and Issue: 27(2), P. 119 - 130

Published: Jan. 1, 2005

Language: Английский

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Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Journal of Pineal Research, Journal Year: 2007, Volume and Issue: 44(3), P. 280 - 287

Published: Oct. 29, 2007

We investigated the relationship between oxidative stress and poor oocyte quality whether antioxidant melatonin improves quality. Follicular fluid was sampled at retrieval during in vitro fertilization embryo transfer (IVF-ET). Intrafollicular concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) women with high rates degenerate oocytes were significantly higher than those low oocytes. As there a negative correlation intrafollicular 8-OHdG melatonin, 18 patients undergoing IVF-ET given (3 mg/day), vitamin E (600 mg/day) or both E. hexanoyl-lysine adduct reduced by these treatments. One hundred fifteen who failed to become pregnant rate (< =50%) previous cycle divided into two groups next procedure; 56 treatment 59 without treatment. The improved compared cycle. However, not changed Oocytes recovered from preovulatory follicles mice incubated H2O2 for 12 hr. percentage mature first polar body addition (300 microm). inhibitory effect blocked simultaneous melatonin. In conclusion, causes toxic effects on maturation protects stress. Melatonin is likely improve rates.

Language: Английский

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Melatonin: A Multitasking Molecule

Progress in brain research, Journal Year: 2010, Volume and Issue: unknown, P. 127 - 151

Published: Jan. 1, 2010

Language: Английский

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Protection against ionizing radiation by antioxidant nutrients and phytochemicals

Toxicology, Journal Year: 2003, Volume and Issue: 189(1-2), P. 1 - 20

Published: June 21, 2003

Language: Английский

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A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes

Journal of Pineal Research, Journal Year: 2005, Volume and Issue: 39(2), P. 99 - 104

Published: June 15, 2005

Abstract: Melatonin, the main secretory product of pineal gland, is known to collaborate against oxidative stress within cells, but its mechanism action in terms stimulating antioxidant enzymes remains unclear. Herein, we propose that melatonin modulates enzyme activities via interaction with calmodulin, which turn inhibits downstream processes lead inactivation nuclear ROR α receptor. Eventually, this transcription factor downregulates NF‐ κ B‐induced expression. Therefore, increment induced by involves inhibition pathway. Thus, addition direct free radical scavenging activities, has important actions defense metabolize radicals and products innocuous metabolites.

Language: Английский

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Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

Critical Reviews in Biochemistry and Molecular Biology, Journal Year: 2009, Volume and Issue: 44(4), P. 175 - 200

Published: July 6, 2009

The discovery of melatonin and its derivatives as antioxidants has stimulated a very large number studies which have, virtually uniformly, documented the ability these molecules to detoxify harmful reactants reduce molecular damage. These observations have clear clinical implications given that numerous age-related diseases in humans an important free radical component. Moreover, major theory explain processes aging invokes radicals their causative agents. conditions, coupled with loss organisms age, suggest some aspects may be aggravated by diminished levels advanced age. Another corollary this is administration melatonin, uncommonly low toxicity profile, could theoretically defer progression possibly forestall signs aging. Certainly, research next decade will help define role determining successful While increasing life span not necessarily goal investigative efforts, improving health quality aged should aim research.

Language: Английский

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Trends in the development of radioprotective agents

Drug Discovery Today, Journal Year: 2007, Volume and Issue: 12(19-20), P. 794 - 805

Published: Sept. 11, 2007

Language: Английский

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