Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants DOI Creative Commons
Chiara Ceresa, Letizia Fracchia,

Emanuele Fedeli

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(4), P. 466 - 466

Published: March 30, 2021

The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated urgent need for methods to combat such increasing threats. New avenues research natural molecules with desirable properties alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group unique varied amphiphilic microbial origin capable interacting lipidic membranes/components microorganisms altering their physicochemical properties. These features encouraged closer investigations these metabolites as new pharmaceutics potential applications clinical, hygiene therapeutic fields. Mounting evidence has indicated that biosurfactants antimicrobial, antibiofilm, antiviral, immunomodulatory antiproliferative activities are exploitable anticancer treatments wound healing applications. Some already approved use food environmental fields, while others currently under investigation development antimicrobials or adjuvants antibiotics suppression eradication strategies. Moreover, due now being explored an alternative current products procedures effective cleaning handwash formulations, antiviral plastic fabric surface coating agents shields masks. In addition, shown promise drug delivery systems medicinal relief symptoms associated SARS-CoV-2 acute respiratory distress syndrome.

Language: Английский

Fungal biosurfactants, from nature to biotechnological product: bioprospection, production and potential applications DOI Open Access
André Felipe da Silva, İbrahim M. Banat, Admir José Giachini

et al.

Bioprocess and Biosystems Engineering, Journal Year: 2021, Volume and Issue: 44(10), P. 2003 - 2034

Published: June 16, 2021

Language: Английский

Citations

91
Microbial biosurfactant research: time to improve the rigour in the reporting of synthesis, functional characterization and process development DOI Creative Commons
Matthew S. Twigg, Niki Baccile, İbrahim M. Banat

et al.

Microbial Biotechnology, Journal Year: 2020, Volume and Issue: 14(1), P. 147 - 170

Published: Nov. 29, 2020

The demand for microbially produced surface-active compounds use in industrial processes and products is increasing. As such, there has been a comparable increase the number of publications relating to characterization novel compounds: producers already characterized production generation these compounds. Leading researchers field have identified that many studies utilize techniques are not precise accurate enough, so some published conclusions might be justified. Such lacking robust experimental evidence generated by validated standard operating procedures detrimental compound research. In this publication, we critically reviewed wide range utilized from microbial sources: identification producing microorganisms functional testing resultant We also required process development take out laboratory into application. devised review as guide both peer-reviewed improve stringency future within science.

Language: Английский

Citations

90
Rhamnolipids produced by Pseudomonas: from molecular genetics to the market DOI Creative Commons
Gloria Soberón‐Chávez, Abigail González‐Valdez, Martín P. Soto‐Aceves

et al.

Microbial Biotechnology, Journal Year: 2020, Volume and Issue: 14(1), P. 136 - 146

Published: Nov. 5, 2020

Summary Rhamnolipids are biosurfactants with a wide range of industrial applications that entered into the market decade ago. They naturally produced by Pseudomonas aeruginosa and some Burkholderia species. Occasionally, strains different bacterial species, like chlororaphis NRRL B‐30761, which have acquired RL‐producing ability horizontal gene transfer, been described. P. , ubiquitous opportunistic pathogenic bacterium, is best rhamnolipids producer, but putida has used as heterologous host for production this biosurfactant relatively good yields. The molecular genetics widely studied not only due to interest in developing overproducing strains, because it coordinately regulated expression virulence‐related traits quorum‐sensing response. Here, we highlight how research mechanisms involved rhamnolipid impacted development suitable biosurfactant, well perspectives improve these useful strains.

Language: Английский

Citations

88
Mannosylerythritol lipids: antimicrobial and biomedical properties DOI
Ana Letícia Silva Coelho, Paulo Emílio Feuser, Bruno Augusto Mattar Carciofi

et al.

Applied Microbiology and Biotechnology, Journal Year: 2020, Volume and Issue: 104(6), P. 2297 - 2318

Published: Jan. 24, 2020

Language: Английский

Citations

85
Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants DOI Creative Commons
Chiara Ceresa, Letizia Fracchia,

Emanuele Fedeli

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(4), P. 466 - 466

Published: March 30, 2021

The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated urgent need for methods to combat such increasing threats. New avenues research natural molecules with desirable properties alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group unique varied amphiphilic microbial origin capable interacting lipidic membranes/components microorganisms altering their physicochemical properties. These features encouraged closer investigations these metabolites as new pharmaceutics potential applications clinical, hygiene therapeutic fields. Mounting evidence has indicated that biosurfactants antimicrobial, antibiofilm, antiviral, immunomodulatory antiproliferative activities are exploitable anticancer treatments wound healing applications. Some already approved use food environmental fields, while others currently under investigation development antimicrobials or adjuvants antibiotics suppression eradication strategies. Moreover, due now being explored an alternative current products procedures effective cleaning handwash formulations, antiviral plastic fabric surface coating agents shields masks. In addition, shown promise drug delivery systems medicinal relief symptoms associated SARS-CoV-2 acute respiratory distress syndrome.

Language: Английский

Citations

85