Social dimensions of chronic respiratory disease: stigma, isolation, and loneliness

Current Opinion in Supportive and Palliative Care, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 14, 2022

Purpose of review Social wellbeing is a core component heath. However, people with chronic respiratory disease report unmet social needs, particularly in relation to stigma, isolation, and loneliness. This considers recent advances understanding these concepts within the context disease. Recent findings A growing body qualitative work illustrates detrimental impacts stigma disease, contributing towards poorer psychological health self-management, reduced engagement professional support. Stigma, alongside physical limitations stemming from symptoms, can also contribute isolation loneliness are associated mental quality life, declines function, some cases, increased hospital admissions. Although close or cohabiting relationships ameliorate challenges, impact informal carers Summary Increasing evidence direct indirect influences dimensions on outcomes for living there lived experiences less understood about complexities optimal interventions address challenges.

Language: Английский

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Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 8, 2023

Abstract It is reported that pulmonary fibrosis has become one of the major long-term complications COVID-19, even in asymptomatic individuals. Currently, despite best efforts global medical community, there are no treatments for COVID-induced fibrosis. Recently, inhalable nanocarriers have received more attention due to their ability improve solubility insoluble drugs, penetrate biological barriers lungs and target fibrotic tissues lungs. The inhalation route many advantages as a non-invasive method administration local delivery anti-fibrosis agents like direct lesion from respiratory system, high efficiency, low systemic toxicity, therapeutic dose stable dosage forms. In addition, lung biometabolic enzyme activity hepatic first-pass effect, so drug rapidly absorbed after administration, which can significantly bioavailability drug. This paper summary pathogenesis current treatment reviews various systems fibrosis, including lipid-based nanocarriers, nanovesicles, polymeric protein nanosuspensions, nanoparticles, gold nanoparticles hydrogel, provides theoretical basis finding new strategies clinical rational use.

Language: Английский

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Navigating the COVID-19 pandemic: Experiences and self-management approaches adopted by people with interstitial lung disease

Chronic Respiratory Disease, Journal Year: 2024, Volume and Issue: 21

Published: Jan. 1, 2024

Background People with interstitial lung disease (ILD) were deemed more vulnerable to the SARS-CoV-2 virus and isolated as a means of reducing risk infection. This study examined impact pandemic on daily life, psychological wellbeing access healthcare identified approaches undertaken remain safe. Methods Four specialist clinics in tertiary centres Australia (Victoria: two sites; New South Wales: one site; Western Australia: site) recruited patients ILD during an 8-week period from March 2021. Semi-structured telephone interviews conducted transcripts analysed using principles grounded theory. Results Ninety participants interviewed between April December Participants predominantly female, former smokers average age 66 years. IPF connective tissue-ILD being most common subtypes. Five main themes identified: vulnerability reduced social interaction isolation, services support, staying active, emotional impact. Self-management strategies included active both physically mentally. Discussion was key managing pandemic. In combination advances technology, implementation for monitoring support self-management provides opportunity leverage lessons learnt ensure individualised model care people ILD.

Language: Английский

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Reflections on nursing research focusing on the COVID‐19 pandemic

Journal of Advanced Nursing, Journal Year: 2022, Volume and Issue: 78(7)

Published: May 2, 2022

The COVID-19 pandemic has consumed nursing for more than 2 years now. Nurses have been and remain at the heart of response to pandemic––nurses are central preventative, curative palliative activities associated with COVID-19, taken these roles on in addition their usual roles. all levels career stages responded affected by pandemic––from students nursing, through academic executive nurses (Heilferty et al., 2021; Ion Riddell 2022). Nurse researchers also very responsive pandemic. Like many other health journals, Journal Advanced Nursing received literally hundreds manuscripts focused pandemic, we published 200 papers over past years. These come from world areas interest, but most dominant topic far effects workforce. Effects workforce felt internationally––the shows that there is not an area or a geographical location escaped Through pages learned about aspects how it experienced world. were quick scrutinize synthesis literature ascertain presenting signs symptoms adult hospitalized patients time when still little was known virus (Keller 2020). There considerable recognition needs particular populations such as older adults those living chronic conditions (Rodrigues 2022; Ryan & Meskell, Searby Burr, 2021), well visitor restrictions community settings (Rodney particularly impacts minority (Altman 2021). Issues loneliness attitudes views vaccination (Burden 2021) disparity (Jackson James raised interrogated relation had deleterious staff uncertainty (Turgut 2022), fear emotional exhaustion (Sarabia-Cobo psychological distress (Hamama burnout (Galanis Manzano García Ayala Calvo, nurses. We gained insights into moral hospital during know causes varied included issues availability personal protective equipment (PPE), concerns transmission infection work home providing care dying alone (Foli Lake McCallum Hospital reported experiencing withdrawal, anxiety difficulty sleeping (Lake Foli al. (2021) provided detailed information caring COVID-19. Respondents this study described anxiety, depression, feeling unsupported, having make tough decisions, dealing intrusive thoughts, isolation family friends, increased use substances maladaptive coping feelings betrayal lack adequate resources, authors highlighted need ensure appropriate support services mental sequelae arising In challenges faced Hamama Hoedl (2022) describe greater workloads, fear, stress striving meet residents members who stressed because (also Sarabia-Cobo go highlight additional (Hoedl working primary stress, acts abuse violence directed towards them (Ashley However, regardless stressors presented Ke found frontline demonstrated strong professional commitment prepared continue suggest some strategies important nurses' willingness work, including provision support, reward contribution, ensuring PPE, access training social coordinating realistic hours. Despite pressures brought shown innovate change practices. created changes ways could interact consumers catalyst develop new inventive deliver (Gardiner MacLellan, Skill mix staffing models changed build capacity demands (Endicott where possible, adopted various forms remote telehealth, which seen be useful effective problematic others (Hughes identified delivering alcohol drug though modality being successful adjunct service people regional locations preference telehealth (Searby Patient safety remained concern nurse (Andel recognize unintended outcomes take steps better understand mitigate issues. Istanboulian recognized communication impairments treated invasive mechanical ventilation intensive unit undertook explore barriers facilitators supporting optimal context. underlying modified approaches best possible delivered (Ryan Similarly, administrators revised processes optimally constraints (Ion proliferation questions remain. several relatively attention, require further scrutiny. longer term yet fully understood includes emergent workforce, newly graduated educational disruption, entering environment. Changes skill metrics enacted whether will retained if previous restored, either original ways. clinical curtailed restricted acute resources redirected This resulted suspension modification services, large scale redeployment different areas. empirical studies patient redeployed. Undoubtedly strategy scrutinized future research findings considering can used events. now long COVID, help us respond families. only high death rates, events funerals this, deprived rituals around loss death. grief rates complicated grief. final extent collaborate share address ability effectively dynamic rapidly changing situation. knowledge produced shared journal public crises. Over coming years, global deal aftermath generate next phases recovery contribute evidence base context disaster emergencies.

Language: Английский

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Polyphyllin VI Ameliorates Pulmonary Fibrosis by Suppressing the MAPK/ERK and PI3K/AKT Signaling Pathways via Upregulating DUSP6

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(12), P. 5930 - 5948

Published: Oct. 17, 2024

ABSTRACT Pulmonary fibrosis (PF) is a lethal disease caused by inordinate repair of damaged lungs, for which limited strategies are available. Polyphyllin VI (PPVI), extracted and isolated from Paris polyphylla Smith var. chinensis (Franch.) Hara, has been regarded as an important traditional Chinese herbal medicine the treatment respiratory system diseases. This study evaluated effects PPVI on PF its underlying mechanism. Experimental procedure For evaluating anti‐PF effect PPVI, we established in vivo mouse model via intratracheal infusion bleomycin (BLM) mice vitro induced TGF‐β1 NIH/3T3, HPF A549, respectively. Subsequently, mechanism was further explored using RNA sequencing (RNA‐Seq). The results demonstrated that significantly inhibited inflammation, oxidative damage, epithelial‐mesenchymal transition. Furthermore, indicated ameliorated modulating inflammation stress responses. dual specificity phosphatase 6 (DUSP6), shared most significant differentially expressed gene associated with response after treatment. Mechanistically, silencing DUSP6 can eliminate suppressive impact activation fibroblast phosphorylation ERK AKT. Summarily, our findings revealed potential mitigating upregulating highlighted regulatory function pathogenesis PF.

Language: Английский

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Preliminary study of the exploration patients' experiences of chronic respiratory experiences during the COVID-19 pandemic using interpretative phenomenological analysis

Psychiatry Research Communications, Journal Year: 2022, Volume and Issue: 3(1), P. 100101 - 100101

Published: Dec. 22, 2022

During the first period of coronavirus pandemic, respiratory patients may have been more vulnerable to mental health problems in addition their physical vulnerability. The aim was explore and deepen our understanding experiences chronic at risk pandemic COVID-19 using interpretative phenomenological analysis. study involved 8 participants with asthma, COPD or cystic fibrosis. Three main themes emerged: 1. illness as a defining experience everyday life, 2. impact on self identity organisation, 3. adaptation experiencing Breathlessness most frightening feature progressive lung disease, can be linked fear anxiety different ways. vulnerability is fundamental part lives. potentially contagious nature draws sharp line between endangered Self dangerous Other. In terms adaptation, we observe essentially self-defense mechanisms emotion-focused strategies.

Language: Английский

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Understanding the telehealth experience of care by people with ILD during the COVID-19 pandemic: what have we learnt?

BMC Pulmonary Medicine, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 6, 2023

The COVID-19 pandemic resulted in a rapid transformation of health services. This study aimed to understand the experiences healthcare by people with interstitial lung disease (ILD), inform future service delivery.Four specialist clinics tertiary centres Australia (Victoria:2 sites; New South Wales: 1 site; Western Australia: site) recruited patients ILD during an 8-week period from March 2021. Participants completed COVID-specific questionnaire focused on health-related 2020.Ninety nine (65% 153) participants questionnaire. 47% had idiopathic pulmonary fibrosis or connective tissue disease-associated ILD, 62% were female and average age was 66 years. Whilst 56% rated their overall 2020 as same months prior, 38% indicated worsening attributed reduced physical activity fear contracting virus. Access professionals 'good' 61%, 'fair-to-poor' for 37% due missed respiratory assessments, telehealth (mainly telephone) being perceived less effective. 89% contact physicians, 68% general practitioners, predominantly via telephone, few video consultations. High satisfaction care reported 78%, lower delays disruption usual services such rehabilitation, dissatisfaction telehealth.People generally satisfied 2020, however access challenging those experiencing deterioration health. Telehealth largely well received but did not always meet needs particularly when unwell.

Language: Английский

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Eating and drinking experience in patients with idiopathic pulmonary fibrosis: a qualitative study

BMJ Open, Journal Year: 2024, Volume and Issue: 14(4), P. e078608 - e078608

Published: April 1, 2024

Objective To explore eating and drinking experiences of patients with idiopathic pulmonary fibrosis (IPF), the impact any changes associated their diagnosis coping mechanisms developed by patients. Setting Pulmonary support groups around UK regional Interstitial Lung Diseases Clinic, Newcastle upon Tyne. Participants 15 IPF (9 men, 6 women), median age 71 years, range (54–92) were interviewed. Inclusion criteria included competent adults (over 18 years) a secure as defined international consensus guidelines. Patients required to have sufficient English language competence consent participate in an interview. Exclusion history other lung diseases, pre-existing swallowing problem causes that may be dysphagia individuals significant communication or memory difficulties render them unable Design A qualitative study based on semistructured interviews used purpose sampling conducted between February 2021 November 2021. Interviews via video videoconferencing call platform telephone call, transcribed data coded analysed using reflexive thematic analysis. Results Three main themes identified, along several subthemes, which were: (1) Eating, such, is no longer pleasure. This theme mainly focused physical sensory effects subsequent emotional social these changes; (2) It something happens naturally just try get it. centred self-determined strategies employed manage drinking; (3) What normal. seeking information better understand patients’ beliefs about what has changed drinking. Conclusions our knowledge, this first report lived experience diagnosis. Findings demonstrate some substantial struggles challenges drinking, affecting physically, emotionally socially. There need provide patient for area further study.

Language: Английский

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The patient perspective of the pandemic

European Respiratory Society eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Language: Английский

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Introduction to chronic respiratory diseases

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 1, 2024

Language: Английский

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