Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of hypertension DOI Creative Commons
Wenjun Chen, Longfei Xiao, Wenlong Guo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Hypertension is a common disease; however, it more prevalent in older adults, and its prevalence increasing younger populations. Numerous studies have revealed that hypertension the composition functionality of intestinal flora are closely correlated. The balance flora, barrier integrity, metabolite content play significant roles occurrence progression hypertension. Therefore, we performed comprehensive review Traditional Chinese medicine (TCM) for hypertension, focusing on role to understand mechanism by which TCM regulates through effects flora. We analyzed findings using terms "traditional medicine," "hypertension," "high blood pressure," "blood "intestinal flora," function," metabolites," other keywords from China National Knowledge Infrastructure, VIP Science Technology, Wanfang Data, PubMed, ScienceDirect databases. found treats regulating microbiota, abundance beneficial bacteria, reducing harmful improving function, compact proteins, permeability, metabolites. use treat promising therapeutic strategy. However, most limited small sample sizes there lack large-scale randomized controlled trials. In future, multi-center clinical trials needed verify efficacy safety TCM, optimize protocols, establish foundation standardized personalized application management.

Language: Английский

Inflammatory Bowel Disease and Cardiovascular Disease: An Integrative Review With a Focus on the Gut Microbiome DOI Open Access
Camila Sánchez Cruz,

Anahi Rojas Huerta,

Jesus Lima Barrientos

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Inflammatory bowel disease (IBD), which includes Crohn's and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract. Recent research indicates significant link between IBD cardiovascular (CVD), leading cause global morbidity mortality. This review examines association CVD, emphasizing role gut microbiome in this relationship. patients have higher risk events, such as coronary artery disease, heart failure, cerebrovascular incidents, primarily due to systemic inflammation, genetic factors, microbiota imbalance (dysbiosis). Dysbiosis increases intestinal permeability, allowing bacterial products enter bloodstream, promotes inflammation endothelial dysfunction, contributing CVD. Understanding microbiome's CVD suggests new therapeutic interventions. Modulating through diet, probiotics, fecal transplantation (FMT) are promising avenues. These interventions aim restore healthy balance, potentially reducing improving outcomes. Additionally, emphasizes importance regular assessments personalized preventive measures managing patients. Such include routine monitoring health, tailored lifestyle modifications, early intervention strategies mitigate risk. By integrating current knowledge, aims improve understanding management interconnected pathophysiology approach will ultimately enhance patient outcomes provide foundation for future clinical practice guidelines area.

Language: Английский

Citations

5
Gut microbiota changes in patients with hypertension: A systematic review and meta‐analysis DOI Creative Commons

Meiling Cai,

Lingyu Lin, Fei Jiang

et al.

Journal of Clinical Hypertension, Journal Year: 2023, Volume and Issue: 25(12), P. 1053 - 1068

Published: Oct. 18, 2023

Abstract Hypertension is a major public health issue worldwide. The imbalance of gut microbiota thought to play an important role in the pathogenesis hypertension. authors conducted systematic review and meta‐analysis clarify relationship between hypertension through conducting electronic search six databases. Our included 19 studies results showed that compared with healthy controls, Shannon significantly decreased [ SMD = −0.13, 95% CI (−0.22, −0.04), p .007]; however, Simpson −0.01, (−0.14, 0.12), .87], ACE 0.18, (−0.06, 0.43), .14], Chao1 0.11, (−0.01, 0.23), .08] did not differ controls. F/B ratio increased 0.84, (0.10, 1.58), .03]. In addition, index was negatively correlated r −0.12, (−0.19, −0.05)], but had no significant correlation SBP 0.10, 0.37)] DBP −0.39, (−0.73, 0.12)]. At phylum level, relative abundance Firmicutes (−0.37, 0.34), .94], Bacteroidetes −0.15, (−0.44, 0.14), .30], Proteobacteria 0.25, 0.51), .06], Actinobacteria 0.21, (−0.11, 0.53), .21] genus Faecalibacterium −0.16, (−0.28, .01], while Streptococcus 0.20, (0.08, 0.32), .001] Enterococcus 0.33), .002] Available evidence suggests hypertensive patients may have microbiota. However, it still needs further validation by large sample size high quality.

Language: Английский

Citations

12
The Microbial Perspective: A Systematic Literature Review on Hypertension and Gut Microbiota DOI Open Access

Alexandros Tsiavos,

Christina Antza, Christina Trakatelli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3698 - 3698

Published: Oct. 30, 2024

Background: Understanding the causes of hypertension is important in order to prevent disease. Gut microbiota (GM) seems play an role, but detailed physiology remains elusive, with alpha diversity being most studied indicator. Objectives: This review aimed systematically synthesize data on gut (alpha diversity) and hypertension. Methods: Databases, including MEDLINE/PubMed, Scopus, EMBASE, citations were queried. We retrieved articles reporting association between A valid critical appraisal tool was also used investigate quality included studies. Results: Eighteen eligible studies met our inclusion criteria. In this report, we focused following indices diversity: Shannon, Chao1, Simpson, Abundance-based Coverage Estimator (ACE) indices. Several observed a significantly lower Shannon index hypertensive patients compared healthy control group. Nevertheless, no statistically significant difference found for ACE controls. higher Firmicutes-to-Bacteroidetes ratio (F/B ratio) consistently controls, indicating potential dysbiosis microbiota. Conclusions: Our systematic indicates that may exhibit imbalance microbiota, evidenced by decreased elevated F/B ratio. However, absence differences secondary (Chao1, ACE) highlights need further research. Well-designed, large-scale are necessary clarify these associations explore role development.

Language: Английский

Citations

4
The association between the oral microbiome and hypertension: a systematic review DOI Creative Commons
Sadeq Ali Al‐Maweri, Abeer A. Almashraqi, Gamilah Al-Qadhi

et al.

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 2, 2025

Background This study systematically reviewed the available evidence regarding potential association between oral microbiota and hypertension.

Language: Английский

Citations

0
Gut Microbiota Modulation after the Administration of an Antihypertensive Milk Fermented with Lactococcus lactis NRRL B-50571 DOI
Lilia M. Beltrán‐Barrientos, José I. Méndez-Romero,

María C. Estrada-Montoya

et al.

ACS Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Gut Microbiota Metabolites and Chronic Diseases: Interactions, Mechanisms, and Therapeutic Strategies DOI Open Access

Wen-Wen Liu,

Lei Wang, Jinmei Ou

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3752 - 3752

Published: April 16, 2025

The gut microbiota, shaped by factors such as diet, lifestyle, and genetics, plays a pivotal role in regulating host metabolism, immune function, overall health. diversity balance of the microbiota are closely linked to onset progression various chronic diseases. A growing body evidence has demonstrated that alterations composition, metabolites significantly associated with cardiovascular diseases, including hypertension, atherosclerosis, heart failure; metabolic disorders obesity, type 2 diabetes, dysfunction-associated steatotic liver disease; gastrointestinal conditions like inflammatory bowel disease colorectal cancer. Despite substantial advances microbiome research, challenges remain fully elucidating causal relationships between disease, well translating these insights into clinical applications. This review aims investigate regulatory pathways via which affects health, disease. Additionally, it highlights emerging strategies for prevention treatment conditions, focusing on microbiota-targeted therapies personalized dietary interventions promising approaches improving health outcomes.

Language: Английский

Citations

0
Changes in the Gastrointestinal Microbiota Induced by Proton Pump Inhibitors—A Review of Findings from Experimental Trials DOI Creative Commons
Reidar Fossmark, Maya Olaisen

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1110 - 1110

Published: May 30, 2024

The use of proton pump inhibitors (PPIs) has increased considerably in many Western countries, and there is concern that numerous conditions diseases associated with PPI may be adverse events. main function gastric acid to defend the organism against orally ingested microorganisms, also alterations not only microbiome but downstream intestinal increase risk disease or alter course preexisting disease. current study a systematic review available evidence from experimental trials investigating effects PPIs on gastrointestinal microbiota by next-generation sequencing. Thirteen studies were identified. seen diversity richness some studies, while larger proportion detected at various taxonomic levels. general finding was caused an bacteria normally found oral both upper lower GI tract. most consistent seemed increases flora along axis Streptococcaceae Streptococcus genus level spp., as well Veillonellaceae, Veillonella Haemophilus.

Language: Английский

Citations

3
Effect of fruits granola (Frugra®) consumption on blood pressure reduction and intestinal microbiome in patients undergoing hemodialysis DOI Creative Commons
Hajime Nagasawa,

Shogo Suzuki,

Takashi Kobayashi

et al.

Hypertension Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

2
Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and Its Impact on Blood Pressure Status: A Cross-Sectional Study DOI Open Access
Chung‐Guei Huang, Wan‐Ni Lin, Li‐Jen Hsin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13344 - 13344

Published: Dec. 12, 2024

Obstructive sleep apnea syndrome (OSAS) is prevalent among children and associated with elevated blood pressure (BP), posing a risk for future hypertension cardiovascular diseases. While the roles of gut microbiota systemic inflammation in OSAS pathogenesis are recognized adults animal models, their impact on pediatric BP remains less understood. This cross-sectional study explored relationships between polysomnographic parameters, microbiota, inflammation, 60 OSAS. Significant associations specific microbial profiles—including beta diversity 31 marker microbes—and variations were observed. These profiles correlated significant alterations markers like interleukin-17 tumor necrosis factor-α. Notably, relative abundance Acinetobacter was related to fluctuations these inflammatory levels. The research further highlighted unique cytokine exhibited by different levels, indicating substantial role influencing health. findings suggest integrating management into comprehensive strategies initiative underscores need investigations decode mechanisms behind associations, which could lead innovative treatments

Language: Английский

Citations

1
Sleeve Gastrectomy Protects Against Hypertension in Rats due to Changes in the Gut Microbiome DOI

Matthew Barron,

Deemantha G. Fernando,

Samantha N. Atkinson

et al.

Journal of Surgical Research, Journal Year: 2024, Volume and Issue: 301, P. 118 - 126

Published: June 25, 2024

Language: Английский

Citations

0