Recent Advances in Electrochemical Sensors for Formaldehyde

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 327 - 327

Published: Jan. 9, 2024

Formaldehyde, a ubiquitous indoor air pollutant, plays significant role in various biological processes, posing both environmental and health challenges. This comprehensive review delves into the latest advancements electrochemical methods for detecting formaldehyde, compound of growing concern due to its widespread use potential hazards. underscores inherent advantages techniques, such as high sensitivity, selectivity, capability real-time analysis, making them highly effective formaldehyde monitoring. We explore fundamental principles, mechanisms, diverse methodologies employed detection, highlighting innovative sensing materials electrodes. Special attention is given recent developments nanotechnology sensor design, which significantly enhance sensitivity selectivity these detection systems. Moreover, this identifies current challenges discusses future research directions. Our aim encourage ongoing innovation field, ultimately leading development advanced, practical solutions contexts.

Language: Английский

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Recent design strategies and applications of small molecule fluorescent probes for food detection

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216232 - 216232

Published: Sept. 30, 2024

Language: Английский

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The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

Journal of Cellular and Molecular Medicine, Journal Year: 2021, Volume and Issue: 25(12), P. 5358 - 5371

Published: May 10, 2021

As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide-sensitive amine oxidase (SSAO) ubiquitous human body fluids, tissues cells. Vascular endothelial cells smooth muscle are rich this formaldehyde-producing enzyme easily damaged owing to consequent cytotoxicity. Consistent with this, increasing evidence suggests that cardiovascular system stages heart development also susceptible harmful effects formaldehyde. Exposure from different sources can induce disease such as arrhythmia, myocardial infarction (MI), failure (HF) atherosclerosis (AS). In particular, long-term exposure high concentrations pregnant women more likely affect embryonic cause malformations than low Specifically, ability mouse embryos effect clearance far lower rat embryos, readily allowing its accumulation. Formaldehyde may exert toxic on inducing stress cardiomyocyte apoptosis. This review focuses current progress understanding influence underlying mechanisms development.

Language: Английский

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A novel fluorescent probe for the detection of formaldehyde in real food samples, animal serum samples and gaseous formaldehyde

Food Chemistry, Journal Year: 2023, Volume and Issue: 411, P. 135483 - 135483

Published: Jan. 13, 2023

Language: Английский

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Electronic cigarettes and cardiovascular disease: epidemiological and biological links

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(6), P. 875 - 888

Published: Feb. 20, 2024

Abstract Electronic cigarettes (e-cigarettes), as alternative nicotine delivery methods, has rapidly increased among youth and adults in recent years. However, cardiovascular safety is an important consideration regarding e-cigarettes usage. e-cigarette emissions, including nicotine, propylene glycol, flavorings, nitrosamine, metals, might have adverse effects on health. A large body of epidemiological evidence indicated that are considered independent risk factor for rates disease occurrence death. The incidence mortality various types disease, such cardiac arrhythmia, hypertension, acute coronary syndromes, heart failure, a modest growth vapers (users e-cigarettes). Although the underlying biological mechanisms not been fully understood, studies validated oxidative stress, inflammation, endothelial dysfunction, atherosclerosis, hemodynamic effects, platelet function play roles which work human body. This minireview consolidates discusses links between disease.

Language: Английский

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Predicting environmental pollutants in the apartment public space: Evaluating the impact of spatial enclosure and monitoring locations

Urban Climate, Journal Year: 2025, Volume and Issue: 59, P. 102277 - 102277

Published: Jan. 6, 2025

Language: Английский

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Metal-organic frameworks encapsulating gold nanoclusters and carbon dots for ratiometric fluorescent detection of formaldehyde in real food samples, construction materials and indoor environments

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 20, 2025

Language: Английский

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5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

Molecular Therapy — Nucleic Acids, Journal Year: 2021, Volume and Issue: 26, P. 295 - 306

Published: July 29, 2021

Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) still unknown. In this study, we found 5′-tiRNA-Cys-GCA was significantly downregulated human and mouse models dissection. The abnormal proliferation, migration, phenotypic transition vascular smooth muscle cells (VSMCs) played crucial role the initiation progression dissection, with as potential switching regulator, because its overexpression inhibited proliferation migration VSMCs increased expression contractile markers. addition, verified signal transducer activator transcription 4 (STAT4) direct downstream target 5′-tiRNA-Cys-GCA. We STAT4 upregulation oxidized low-density lipoprotein (ox-LDL)-treated VSMCs, which promoted cell transformation, reversed by Furthermore, treatment reduced incidence prevented malignant process angiotensin II- β-aminopropionitrile-induced AD mice. conclusion, our findings reveal is regulator pathological via signaling pathway, providing clinical for development future strategies IntroductionThe definition rupture intima due to various reasons, causing blood from orifice enter wall, forming arterial wall separation..1Sun Y. Xiao Sun H. Zhao Z. Zhu J. Zhang L. Dong Han T. Jing Q. Zhou miR-27a regulates remodeling targeting endothelial cells' apoptosis interaction dissection.Theranostics. 2019; 9: 7961-7975Crossref PubMed Scopus (21) Google Scholar,2Cheng M. Yang Xin Li Zong He X. Yu Non-coding RNAs dissection: From biomarkers therapeutic targets.J. Cell. Mol. Med. 2020; 24: 11622-11637Crossref (20) Scholar Eighty percent patients die rupture;3Thompson R.W. Detection management aneurysms.N. Engl. 2002; 346: 1484-1486Crossref (45) hence, once occurs, patient should be immediately hospitalized given surgical intervention. (VSMCs), an important constituent vessels, believed play onset AD.4Liu S. Jiang Tang N. Tian Ponnusamy Tariq M.A. Lian Understanding RNA (ncRNA) stent restenosis.Atherosclerosis. 2018; 272: 153-161Abstract Full Text PDF (36) have prominent feature called flexibility, enables them alternate between (differentiated) synthetic (dedifferentiated) phenotypes.5Li F.J. C.L. Luo X.J. Peng T.L. Involvement MiR-181b-5p/HMGB1 Pathway Ang II-induced Phenotypic Transformation Smooth Muscle Cells Hypertension.Aging Dis. 10: 231-248Crossref (24) Scholar, 6Wang C.Q. G.Y. Huang H.Y. Y.S. Ji Z.C. Shen Z.Y. MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Switch Migration Thoracic Aortic Dissection.Mol. Ther. Nucleic Acids. 16: 284-294Abstract (28) 7Davis-Dusenbery B.N. Wu C. Hata A. Micromanaging differentiation modulation.Arterioscler. Thromb. Vasc. Biol. 2011; 31: 2370-2377Crossref (180) 8Fu P. Wang Zou et al.Nicotine: Regulatory mechanisms atherosclerosis progression.Food Chem. Toxicol. 2021; 151: 112154Crossref (18) Contractile characterized high α-smooth actin (α-SMA) capabilities. contrast, contain low levels markers exhibit migration.9Owens G.K. Kumar M.S. Wamhoff B.R. Molecular regulation disease.Physiol. Rev. 2004; 84: 767-801Crossref (2536) accelerate occurrence alternations caused stimulants, such (ox-LDL) platelet-derived growth factor BB (PDGF-BB).10Inamoto Kwartler C.S. Lafont A.L. Liang Y.Y. Fadulu V.T. Duraisamy Willing Estrera Safi Hannibal M.C. al.TGFBR2 mutations alter phenotype predispose thoracic aneurysms dissections.Cardiovasc. Res. 2010; 88: 520-529Crossref (100) 11Jones J.A. Beck Barbour J.R. Zavadzkas Mukherjee R. Spinale F.G. Ikonomidis J.S. Alterations cellular constituents during aneurysm development: myofibroblast-mediated remodeling.Am. Pathol. 2009; 175: 1746-1756Abstract (54) 12Wang Liu Yuan Suppression miR-4463 promotes treated Ox-LDL.Cell Tissue 383: 1155-1165Crossref (7) Vascular involves subsequently damaging state balance.13McMurtry Bonnet Dyck Haromy Hashimoto K. Michelakis E.D. Dichloroacetate prevents reverses pulmonary hypertension inducing artery apoptosis.Circ. 95: 830-840Crossref (371) Scholar,14Yang Guo Meng Aung L.H.H. Targeting epigenome in-stent restenosis: therapy.Mol. 23: 1136-1160Abstract addition also link progression.15Liao W.L. Tan M.W. Xu Brahma-related gene 1 inhibits directly up-regulating Ras-related associated diabetes pathophysiologic processes dissection.J. Thorac. Cardiovasc. Surg. 2015; 150 (1292–301.e2)Abstract (16) Scholar,16Wang Fu W. D. Association phenotypes extracellular matrix disorders dissection.J Vasc 2012; 56: 1698-1709Abstract (72) Recent studies confirmed compared control group, samples more common.17Xiao Ma G. al.MicroRNA-22 Inhibits Apoptosis Cell p38MAPKα Remodeling 22: 1051-1062Abstract (13) Scholar,18Shi B. MST1 down-regulation decreasing apoptosis.Eur. Pharmacol. Sci. 2044-2051PubMed Therefore, elucidation involved conversion under conditions essential new diagnosis AD.The stress-induced (tiRNAs) kind newly discovered produced mature tRNAs.14Yang Scholar,19Li Sheng tRNA-Derived Small RNA: A Novel Non-Coding RNA.Genes (Basel). 246Crossref (148) 20Li J.X. Piwi-interacting (piRNAs) targets cardiovascular diseases.Angiogenesis. 19-34Crossref (26) 21Yang P.F. miRNAs diagnostic disease particular focus on WO2010091204.Expert Opin. Pat. 2017; 27: 1021-1029Crossref (32) Under specific conditions, tRNAs cleaved angiogenin (ANG), position anticodon loop will produce two kinds tiRNAs. These tiRNAs 5′-tiRNAs 3′-tiRNAs, length approximately 28–36 nts.16Wang Scholar,22Saikia Krokowski Guan B.J. Ivanov Parisien Hu G.F. Anderson Pan Hatzoglou Genome-wide identification quantitative analysis tRNA induced stress.J. 287: 42708-42725Abstract (147) 23Yamasaki Angiogenin cleaves translational repression.J. 185: 35-42Crossref (572) 24He Expression profiles transfer RNA-derived atherosclerosis.J. 25: 7052-7065Crossref (9) 25Zhang R.C. function molecular mechanism formaldehyde heart development.J. 5358-5371Crossref (15) 26Yang Zhan Shan Ding al.Blood TfR+ exosomes separated pH-responsive method deliver chemotherapeutics tumor therapy.Theranostics. 7680-7696Crossref (50) report tiRNAs, may biological functions, abnormally expressed or participate certain diseases, cancer, neurological, metabolic, viral infectious diseases.26Yang 27Shen Yan Transfer halves: biogenesis, functions diseases.J. (Berl.). 96: 1167-1176Crossref (104) 28Zhang Shi Cao Gao Ren Ning al.Identification characterization ancient enriched serum associating active infection.J. 2014; 6: 172-174Crossref 29Qi Selective arginine deprivation single injection non-uptake deiminase nanocapsules sustained inhibition.Nanoscale. 12: 24030-24043Crossref 30Qi Xue Stability Maintenance Protein Drugs Organic Coatings Based Nanogels.Pharmaceutics. 115Crossref (11) Notably, recent 5′-tiRNA regulating cancer cells31Mo Mao Wei F. fragment, 5′-tiRNAVal, suppresses Wnt/β-catenin pathway FZD3 breast cancer.Cancer Lett. 457: 60-73Crossref (66) biomarker ischemia-reperfusion damage death.32Elkordy Rashad Shehabeldeen Mishima E. Niizuma Abe Tominaga assessment vitro model rat neuronal PC12 cells.Brain 1714: 8-17Crossref However, relationship diseases whether altering unknown.Signal member STAT family.33Verhoeven Tilborghs Jacobs De Waele Quatannens Deben Prenen Pauwels Trinh X.B. Wouters al.The controversy family members cancer.Semin. Cancer 60: 41-56Crossref (113) protein located surfaces.34Lv Ye deficiency protects against neointima formation following injury mice.J. Cardiol. 74: After phosphorylation JAK proteins, proteins nucleus, combine transcripts, regulate genes related differentiation.35Guo Zarella Wagner W.D. atherosclerosis.Exp. 2006; 81: 15-22Crossref highly organs, including testis, spleen, heart, brain, thymus.36Yamamoto Kobayashi Arai Miura O. Hirosawa Miyasaka cDNA cloning, chromosome mapping gene: both STAT1 mapped 2q32.2-->q32.3.Cytogenet. Genet. 1997; 77: 207-210Crossref several can detected main apoptosis.34Lv Scholar,35Guo hypothesized cells.Our study explores AD. Our shed light identify regulatory pathways VSMCs. Future research focused present interventional AD.ResultsDifferential localization vivo vitroWe first level aorta. normal aorta, co-localized α-SMA, suggesting most likely (Figure 1A). Moreover, tissue lower than aorta (Figures 1A 1B). Consistent these data, mice 2.5× 1C). suggest serve protective To further investigate function, mimicked treating ox-LDL (100 μg/mL), plays vital VSMCs.37Xue Cho J.Y. Functional ginsenosides Panax ginseng Ginseng 45: 22-31Crossref (46) 38Tang Noncoding mellitus.Cardiovasc. 36: e12436Crossref 39Bai Chu X.M. NLRP3 inflammasome dysfunction.Cell Death 11: 776Crossref (116) 40He Long PEBP1P2 Suppresses Proliferative Switching Proliferation Atherosclerosis.Mol. 84-98Abstract (34) 41Wang noncoding XXYLT1-AS2 adhesion binding FUS HUVEC.Atherosclerosis. 298: 58-69Abstract 42Liu al.Insights into circRNA angiogenesis implications.Atherosclerosis. 14-26Abstract (55) 43Yu Jie Kim kinase inhibitor BX795 inflammatory response multiple kinases.Biochem. 174: 113797Crossref (29) Interestingly, after treatment, exhibited downward trend time-dependent manner 1D). Together, results indicate abundantly close association AD; were interested studying AD.Overexpression then synthesized transfected mimics 24 h transfection 2A), indicating successfully incorporated cells. counting kit-8 (CCK-8) experiment performed same showed 2B). 5-ethynyl-2′-deoxyuridine (EdU) assay inhibitory effect 2C). suppressed ability wound healing 2D) Transwell assays 2E). next determined observed 2F), specifically while calponin (CNN1) myosin heavy chain (SMHC) did not show significant changes.9Owens By rates change 2H), detecting apoptosis-related p53 caspase-3 (c-caspase-3; Figure 2G).44Du Qian Chen Zheng Pu Xia Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury TLR4/MyD88/NF-κB Signal Vivo Vitro.Oxid. Longev. 2019: 3765898Crossref (30) Scholar,45Su Lv X.W. Y.L. Cai R.P. Dai R.X. X.H. W.K. Kong B.H. Exosomal LINC00174 derived attenuates myocardial I/R p53-mediated autophagy apoptosis.Mol. 1304-1322Abstract summary, mainly regulated affect VSMCs.Figure 2Overexpression vitroShow full caption(A) used overexpress using real-time PCR. (B C) (B) cell-light EdU staining (C) measure at 0, 12, 24, 36 h. (D E) analyzed wound-healing (D) (E) assay. (F) Western blotting analyses conducted (G H) TUNEL (G) western blot (H) detect Data presented mean ± SD. Each repeated least three times. Scale bars, 200 μm. ∗p < 0.05; ∗∗p 0.01; ∗∗∗p 0.001; ∗∗∗∗p 0.0001; ns, significant.View Large Image ViewerDownload Hi-res image Download (PPT)Knockdown vitroThe knockdown 3A), consequently 3B 3C). Simultaneously, accelerated 3D 3E), 3F). any 3G 3H). validating 3Knockdown inhibitors down-express qPCR. CCK-8 down-expression ware (PPT)5′-tiRNA-Cys-GCA binds downregulates STAT4Investigation 5′-tiRNA-Cys-GCA-mediated KEGG ontology (GO) identified total 153 predicted 4A). revealed only 9 migration. targets, namely STAT4, PC nanoparticles (PCNP), cysteine rich secretory LCCL domain containing 2 (CRISPLD2), pulled down 4B). PCR (qPCR) remaining six (JAK3, KCNE3, HBEGF, TLR4, TREM1, TNFAIP8L2) undetermined Ct values, very levels. had highest enrichment, implying it probable Using miRanda TargetScan software, site 4C) structure score, free energy, Context+ values 145, −24.79, −0.303, respectively. Further displayed degree conservation humans, mice, rats 4C). Additional experiments mRNA 4D) 4E), correspondingly expression. Finally, dual luciferase reporter fluorescence intensities overexpressed wild-type plasmid reduced, there no mutant group. Taken together, bind activities.Figure 45′-tiRNA-Cys-GCA STAT4Show Predicted kyoto encyclopaedia genomes (KEGG) enrichment predictions, literature review pull-down selected. Pull-down Theoretically STAT4. qPCR NC STAT4-3′ UTR-WT mut co-transfected NC. Luciferase activity decreased (PPT)STAT4 ox-LDL-induced transformation 5′-tiRNA-Cys-GCAWe designed interfering (siRNA)-mediated validate 5′-tiRNA-Cys-GCA/STAT4 axis First, siRNA knocks

Language: Английский

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Association between urinary metabolites of volatile organic compounds and cardiovascular disease in the general population from NHANES 2011–2018

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 264, P. 115412 - 115412

Published: Sept. 14, 2023

Volatile organic compounds (VOCs) contain hundreds of chemicals and human exposure to VOCs is pervasive. However, most studies have considered only a single chemical or class similar chemicals.We aimed investigate the association between urinary volatile compound metabolites (mVOCs) risk cardiovascular disease (CVD) in general population.The data this study were collected from National Health Nutrition Examination Survey 2011-2018. Eligible patients aged ≥20 years for whom complete 20 types mVOCs CVD outcomes available. Multivariate logistic regression models used elucidate CVD. Generalized additive examine nonlinear relationships CVD.6814 indiviuals included final analysis, 508 had Higher concentrations N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) N-Acetyl-S-(2-cyanoethyl)-l-cysteine (CYMA) lower concentration 2-aminothiazoline-4-carboxylic acid (ATCA) associated with after adjustment potential confounding factors. A relationship threshold effect observed N-acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) among mVOCs. There was significantly positive correlation AMCC when >2.32 g/mL.The findings suggested significant VOC Urinary may indicate hazardous distinct metabolic traits

Language: Английский

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A visible-light-assisted Pd/TiO2 gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

Rare Metals, Journal Year: 2023, Volume and Issue: 43(1), P. 257 - 266

Published: Nov. 28, 2023

Language: Английский

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