Majallah-i dānishgāh-i ̒ulum-i pizishkī-i Kirmān.,
Journal Year:
2025,
Volume and Issue:
32, P. 3983 - 3983
Published: Jan. 7, 2025
Background:
Formaldehyde
(FA)
is
a
chemical
precursor
that
has
toxic
effects
on
several
systems,
including
the
reproductive
system.
Rosa
damascena
L.
(RD)
an
ancient
herbal
drug
with
various
antioxidant
substances.
In
present
study,
of
RD
mouse
ovaries
against
FA
toxicity
were
investigated.
Methods:
this
48
adult
female
NMRI
mice
included
and
divided
randomly
into
six
groups
(n=8):
control,
10%
group
received
single
dose
(10
mg/kg
which
was
diluted
in
normal
saline)
intraperitoneally
(i.p),
FA+RD10,
FA+RD20,
FA+RD40
extract
10,
20,
40
mg/kg/d
orally,
respectively,
following
injection,
RD40
only
without
administration.
Results:
After
days
treatment,
estrogen
progesterone
levels
decreased
serum
relative
to
(P<0.001).
Also,
ovary
weight,
volume
diameter
(WVD),
number
different
ovarian
follicles
significantly
reduced
FA-treated
(P<0.05).
Treatment
doses
improved
harmful
FA.
Conclusion:
Based
available
evidence
especially
its
low
mg/kg)
can
protect
toxicity.
CNS Neuroscience & Therapeutics,
Journal Year:
2022,
Volume and Issue:
28(8), P. 1183 - 1194
Published: May 18, 2022
Abstract
Introduction
Acute
high‐altitude
hypoxia
exposure
causes
multiple
adverse
neurological
consequences.
However,
the
exact
mechanisms
are
still
unclear,
and
there
is
no
targeted
treatment
with
few
side
effects.
Excessive
cerebral
formaldehyde
(FA)
impairs
numerous
functions,
can
be
eliminated
by
nano‐packed
coenzyme
Q10
(CoQ10).
Aims
In
this
study,
we
aimed
to
investigate
whether
FA
was
accumulated
after
hypobaric
exposure,
further
explored
preventative
effect
of
CoQ10
through
elimination.
Results
Accumulated
found
in
C57BL/6
mice
acute
which
resulted
metabolic
disturbance
elevation
semicarbazide‐sensitive
amine
oxidase,
declination
aldehyde
dehydrogenase‐2.
also
induce
neuronal
ferroptosis
vivo.
Excitingly,
administration
for
3
days
before
reduced
accumulation,
alleviated
subsequent
ferroptosis,
preserved
functions.
Conclusion
Cerebral
accumulation
mediates
deficits
under
hypoxia,
supplementation
may
a
promising
strategy
visitors
sojourners
at
plateau.
Majallah-i dānishgāh-i ̒ulum-i pizishkī-i Kirmān.,
Journal Year:
2025,
Volume and Issue:
32, P. 3983 - 3983
Published: Jan. 7, 2025
Background:
Formaldehyde
(FA)
is
a
chemical
precursor
that
has
toxic
effects
on
several
systems,
including
the
reproductive
system.
Rosa
damascena
L.
(RD)
an
ancient
herbal
drug
with
various
antioxidant
substances.
In
present
study,
of
RD
mouse
ovaries
against
FA
toxicity
were
investigated.
Methods:
this
48
adult
female
NMRI
mice
included
and
divided
randomly
into
six
groups
(n=8):
control,
10%
group
received
single
dose
(10
mg/kg
which
was
diluted
in
normal
saline)
intraperitoneally
(i.p),
FA+RD10,
FA+RD20,
FA+RD40
extract
10,
20,
40
mg/kg/d
orally,
respectively,
following
injection,
RD40
only
without
administration.
Results:
After
days
treatment,
estrogen
progesterone
levels
decreased
serum
relative
to
(P<0.001).
Also,
ovary
weight,
volume
diameter
(WVD),
number
different
ovarian
follicles
significantly
reduced
FA-treated
(P<0.05).
Treatment
doses
improved
harmful
FA.
Conclusion:
Based
available
evidence
especially
its
low
mg/kg)
can
protect
toxicity.
