IoT and Nano‐Bioelectronics for Target Drug Delivery DOI
Ambikesh Soni,

Pratiksha Singh,

Gagan Kant Tripathi

et al.

Published: Oct. 8, 2024

With the global expansion of several cancerous variants nowadays new drugs and treatments are desperately needed. The Internet Things (IoT) has played a significant role in recent advancements healthcare technologies. research objectives field nano-biotechnologies for drug delivery encompass key goals. These include enhancing precision efficiency targeting delivery, minimizing toxicity levels while retaining therapeutic efficacy, ensuring optimal safety biocompatibility, accelerating development process secure medications. undergone progressive change due to ubiquitous computing. By deploying such IoT-based devices, health professionals can better serve society. study will introduce model "Smart Portable Intensive Care Unit" based on remote distribution real-time patient monitoring. suggested paradigm allows medical staff patient's family remotely monitor physiological data.

Language: Английский

Nano‐biotechnology in tumour and cancerous disease: A perspective review DOI Creative Commons
Ambikesh Soni, Manohar Prasad Bhandari, Gagan Kant Tripathi

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(6), P. 737 - 762

Published: Feb. 24, 2023

Abstract In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach improve delivery system for tumour cancer diseases. this article, we review current strategies delivery, which mainly focuses on sustaining biocompatibility, biodistribution, active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, paclitaxel has its own challenges especially not being able discriminate between versus normal cells eventually led toxicity side effects in patients. contrast approach, nanoparticle‐based provides target‐specific controlled release of drug, a better therapeutic window treatment options by focusing eradication diseased via targeting sparing passive Additionally, tumours associated with brain is hampered impermeability blood–brain barriers drugs, poor survival Nanoparticle‐based offers superior target breaching barriers. Herein, provide an overview properties nanoparticles that are crucial nanotechnology applications. We address potential future applications specific or desired areas. particular, use nanomaterials, biostructures, methods targeted explored.

Language: Английский

Citations

34

Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment DOI Open Access
Agnishwar Girigoswami, Koyeli Girigoswami

Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1370 - 1370

Published: June 28, 2023

Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each these therapies has its own limitations, such as the indiscriminate killing normal well cells, solubility chemotherapeutic drugs, rapid clearance drugs from circulation before reaching tumor site, resistance cells to radiation, and over-sensitization radiation. Other treatment modalities include gene immunological checkpoint inhibitors, drug repurposing, in situ cryo-immune engineering (ICIE) strategy. Nanotechnology come rescue overcome many shortfalls therapies. Some nano-formulated nanoparticles nanostructures with surface modifications, have been used for effective cell radio sensitization, respectively. Nano-enabled delivery systems act cargo deliver sensitizer molecules specifically thereby enabling therapy be more effective. In this review, we discussed different chemotherapies inhibiting lung cancer. We also improvement chemotherapy sensitization nanoparticles.

Language: Английский

Citations

26

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance DOI Creative Commons
Jianjun Lai, Zhizeng Luo, Liting Chen

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(1)

Published: Jan. 1, 2024

X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis treatment. However, traditional contrast agents inadequate the of various health conditions. Consequently, development targeted nano-contrast has become a crucial area focus image-enhancing agents. To fully understand current agents, this review provides an overview preparation methods research advancements CT MR CT/MR multimodal described previous publications. Due to physicochemical properties nanomaterials, such as self-assembly surface modifiability, these specific can greatly improve targeting lesions through clearly highlight distinction between normal tissues both MR. As result, they have potential be used early stages disease diagnostic capacity level imaging.

Language: Английский

Citations

14

Doxorubicin loaded thermostable nanoarchaeosomes: a next-generation drug carrier for breast cancer therapeutics DOI Creative Commons

Kaviya Vijayalakshmi Babunagappan,

Abirami Seetharaman,

Subastri Ariraman

et al.

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(8), P. 2026 - 2037

Published: Jan. 1, 2024

Nanoarchaeosomes as a next-generation drug carrier for cancer therapeutics.

Language: Английский

Citations

9

The Multifaceted Perspective on the Role of Green Synthesis of Nanoparticles in Promoting a Sustainable Green Economy DOI Creative Commons
Manish Kumar Sah,

Biraj Shah Thakuri,

J. Pant

et al.

Sustainable Chemistry, Journal Year: 2024, Volume and Issue: 5(2), P. 40 - 59

Published: March 25, 2024

The current economic development paradigm, which is based on steadily rising resource consumption and pollution emissions, no longer viable in a world with limited resources ecological capacity. “green economy” idea has presented this context chance to alter how society handles the interplay between environmental spheres. related concept of nanotechnology” aims use nano-innovations within fields materials science engineering generate products processes that are economically ecologically sustainable, enabling establish preserve green economy. Many different sectors anticipated be impacted by these applications, including those corrosion inhibitor nanofertilizers, nanoremediation, biodegradation, heavy metal detection, biofuel, insecticides pesticides, catalytic CO2 reduction. These innovations might make it possible non-traditional water sources safely create construction enabled nanotechnology, improving living conditions. Therefore, our aim highlight nanotechnology being used economy present promises for nano-applications domain. In end, emphasizes critical attain truly sustainable advancement nanotechnology.

Language: Английский

Citations

9

An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management DOI Creative Commons
Hitesh Chopra, Yugal Kishore Mohanta, Pradipta Ranjan Rauta

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 581 - 581

Published: April 12, 2023

Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, high pill burden, limited compliance, and strict administration schedules are all variables that contribute to development MDR XDR tuberculosis patients. The rise multidrug-resistant strains scarcity anti-TB medications pose threat TB control in future. As result, strong effective system required overcome technological limitations improve efficacy therapeutic medications, which still huge problem for pharmacological technology. Nanotechnology offers an interesting opportunity accurate identification mycobacterial improved medication treatment possibilities tuberculosis. Nano medicine emerging research field provides possibility efficient delivery using nanoparticles decrease drug dosages adverse effects boost patient compliance with therapy recovery. Due their fascinating characteristics, this strategy useful overcoming abnormalities associated traditional leads some optimization impact. It also decreases dosing frequency eliminates low compliance. To develop modern diagnosis techniques, upgraded possible prevention tuberculosis, nanoparticle-based tests have demonstrated considerable advances. literature search was conducted Scopus, PubMed, Google Scholar, Elsevier databases only. This article examines employing nanotechnology diagnosis, nanotechnology-based systems, successful elimination illnesses.

Language: Английский

Citations

20

Synthesis and characterization of new electrospun medical scaffold-based modified cellulose nanofiber and bioactive natural propolis for potential wound dressing applications DOI Creative Commons
Yassine El‐Ghoul,

Abdulmohsen S. Altuwayjiri,

Ghadah A. Alharbi

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(36), P. 26183 - 26197

Published: Jan. 1, 2024

Recently, the design of polymer nanofibers using electrospinning process has attracted much interest. Particularly use natural polymers promoted many advantages in their biomedical applications. However, combination multiple remains a great challenge terms electrospun production and applied performance. From this perspective, current investigation highlights study preparation nanomaterial scaffolds based on combined for improved wound healing First, we have synthesized crosslinked by reacting microcrystalline cellulose (MC) chitosan (CS) biopolymer

Language: Английский

Citations

6

A comprehensive review of cancer therapies mediated by conjugated gold nanoparticles with nucleic acid DOI Open Access
Sayedeh Azimeh Hosseini, Arefeh Kardani, Hajar Yaghoobi

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127184 - 127184

Published: Oct. 3, 2023

Language: Английский

Citations

14

A Facile Synthesis of Flower-like Iron Oxide Nanoparticles and Its Efficacy Measurements for Antibacterial, Cytotoxicity and Antioxidant Activity DOI Creative Commons
Nazish Tabassum,

Virendra Singh,

Vivek K. Chaturvedi

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1726 - 1726

Published: June 14, 2023

The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. structural morphological characteristics synthesized Fe2O3 analyzed XRD, UV-Vis, FTIR, SEM, EDX, TEM, HR-TEM techniques. Furthermore, cytotoxic effects on MCF-7 HEK-293 cells evaluated in vitro cell viability assays, while antibacterial activity against Gram-positive Gram-negative bacteria (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae) also tested. results our demonstrated potential toward lines. antioxidant evidenced by 1,1-diphenyl-2-picrylhydrazine (DPPH) nitric (NO) free radical scavenging assays. In addition, we suggested could be used various applications prevent spread different bacterial strains. Based these findings, concluded have great for use pharmaceutical biological applications. effective biocatalytic recommends its as one best drug treatments future views cancer cells, it is, therefore, recommended both vivo biomedical field.

Language: Английский

Citations

13

Phosphatidylcholine (PCL) fortified nano-phytopharmaceuticals for improvement of therapeutic efficacy. DOI
Devesh U. Kapoor,

Mansi Gaur,

Akshay Parihar

et al.

PubMed, Journal Year: 2023, Volume and Issue: 22, P. 880 - 903

Published: Jan. 1, 2023

Phytopharmaceuticals, derived from plants, are increasingly recognized for their potential therapeutic benefits. However, effectiveness is often hindered by challenges such as poor bioavailability, stability, and targeted delivery. In this study, we aimed to address these limitations developing PCL (phosphatidylcholine) fortified nano-phytopharmaceuticals enhance efficacy. PCL, a biocompatible biodegradable polymer, was employed encapsulate the phytopharmaceuticals, thereby improving stability bioavailability. The encapsulation process utilized nanoprecipitation, resulting in formation of nanoparticles with controlled size morphology. Various analytical techniques were characterize physicochemical properties nano-phytopharmaceuticals, including dynamic light scattering, scanning electron microscopy, Fourier-transform infrared spectroscopy. Furthermore, release kinetics encapsulated phytopharmaceuticals evaluated, demonstrating sustained profiles, essential prolonged effects. Cytotoxicity studies conducted on

Language: Английский

Citations

11