Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Neprilysin
(NEP),
a
zinc-dependent
membrane-bound
metallopeptidase,
regulates
various
bioactive
peptides,
particularly
in
kidneys,
vascular
endothelium,
and
the
central
nervous
system.
NEP’s
involvement
metabolizing
natriuretic
insulin,
enkephalins
makes
it
promising
target
for
treating
cardiovascular
Alzheimer’s
diseases.
Several
NEP
inhibitors,
such
as
sacubitril
omapatrilat,
have
been
approved
clinical
use,
which
inhibit
activity
to
prolong
bioactivity
of
beneficial
thereby
exerting
therapeutic
effects.
However,
despite
broad
application
prospects
they
still
specific
adverse
reactions
side
effects,
hypotension,
renal
impairment,
potentially
increased
risk
disease.
This
manuscript
comprehensively
reviews
progress
on
single-target
dual-target
inhibitors.
Dual-target
inhibitors
often
combine
with
other
targets,
angiotensin
receptors,
enhance
effects
reduce
reactions.
The
article
also
emphasizes
these
inhibitors'
design
strategies,
structure-activity
relationships
(SAR),
safety,
performance.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(10)
Published: May 1, 2024
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
of
the
brain
and
manifested
by
motor
non-motor
symptoms
because
degenerative
changes
in
dopaminergic
neurons
substantia
nigra.
PD
neuropathology
associated
with
mitochondrial
dysfunction,
oxidative
damage
apoptosis.
Thus,
modulation
apoptosis
growth
factors
could
be
novel
boulevard
management
PD.
Brain-derived
neurotrophic
factor
(BDNF)
its
receptor
tropomyosin
kinase
type
B
(TrkB)
are
chiefly
involved
neuropathology.
BDNF
promotes
survival
nigra
enhances
functional
activity
striatal
neurons.
Deficiency
TrkB
triggers
degeneration
accumulation
α-Syn
As
well,
BDNF/TrkB
signalling
reduced
early
phase
Targeting
specific
activators
may
attenuate
this
review
aimed
to
discuss
potential
role
against
In
conclusion,
decreased
linked
severity
long-term
complications.
Activation
Journal of Cellular and Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
28(2)
Published: Oct. 17, 2023
Alzheimer's
disease
(AD)
is
a
heterogeneous
neurodegenerative
with
multifaceted
neuropathological
disorders.
AD
characterized
by
intracellular
accumulation
of
phosphorylated
tau
proteins
and
extracellular
deposition
amyloid
beta
(Aβ).
Various
protease
enzymes,
including
neprilysin
(NEP),
are
concerned
the
degradation
clearance
Aβ.
Indeed,
defective
neuronal
pathway
due
to
dysfunction
enzymes
might
be
possible
mechanism
for
Aβ
subsequent
progression
neuropathology.
NEP
one
most
imperative
metalloproteinase
involved
in
This
review
aimed
highlight
role
inhibitors
AD.
The
combination
sacubitril
valsartan
which
called
angiotensin
receptor
blocker
inhibitor
(ARNI)
may
produce
beneficial
deleterious
effects
on
increase
risk
inhibition
clearance,
brain
bradykinin
(BK)
natriuretic
peptides
(NPs),
augment
pathogenesis
These
verdicts
come
from
animal
model
studies,
though
they
not
applied
humans.
However,
clinical
studies
revealed
promising
safety
findings
regarding
use
ARNI.
Moreover,
increases
various
neuroprotective
inflammation,
glucose
homeostasis
nerve
conduction.
Also,
inhibit
dipeptidyl
peptidase
4
(DPP4)
expression,
ameliorating
insulin
glucagon-like
peptide
1
(GLP-1)
levels.
proposed
that
have
protective
effect
against
development
increasing
GLP-1,
neuropeptide
Y
(NPY)
substance
P,
BK.
Preclinical
recommended
this
regard.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: June 5, 2024
Amyotrophic
lateral
sclerosis
(ALS)
is
a
progressive
neurodegenerative
disease
of
motor
neurons
characterized
by
muscle
weakness,
twitching,
and
wasting.
ALS
regarded
as
the
third-most
frequent
disease,
subsequent
to
Alzheimer's
(AD)
Parkinson's
(PD).
The
World
Health
Organization
(WHO)
in
2007
declared
that
prolonged
use
statins
may
induce
development
ALS-like
syndrome
increase
risk.
Subsequently,
different
studies
have
implicated
pathogenesis
ALS.
In
contrast,
results
from
preclinical
clinical
highlighted
protective
role
against
neuropathology.
Recently,
meta-analyses
systematic
reviews
illustrated
no
association
between
long-term
These
findings
controversial
points
regarding
effects
on
neuroprotective
progression
be
mediated
regulating
dyslipidemia
inflammatory
changes.
However,
mechanism
for
induction
neuropathology
related
dysregulation
liver
X
receptor
signaling
(LXR)
reduction
cholesterol,
which
has
effect
Nevertheless,
exact
was
not
fully
elucidated.
Therefore,
this
narrative
review
aims
discuss
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 938 - 938
Published: Aug. 1, 2024
Frontotemporal
dementia
(FTD)
includes
a
number
of
neurodegenerative
diseases,
often
with
early
onset
(before
65
years
old),
characterized
by
progressive,
irreversible
deficits
in
behavioral,
linguistic,
and
executive
functions,
which
are
difficult
to
diagnose
due
their
similar
phenotypic
characteristics
other
dementias
psychiatric
disorders.
The
genetic
contribution
is
utmost
importance,
although
environmental
risk
factors
also
play
role
its
pathophysiology.
In
fact,
some
metals
known
produce
free
radicals,
which,
accumulating
the
brain
over
time,
can
induce
oxidative
stress,
inflammation,
protein
misfolding,
all
these
being
key
features
FTD
conditions.
Therefore,
present
review
aims
summarize
current
evidence
about
FTD-mainly
dealing
toxic
metal
exposure-since
identification
such
potential
lead
diagnosis
promotion
policies
interventions.
This
would
allow
us,
reducing
exposure
pollutants,
potentially
affect
society
at
large
positive
manner,
decreasing
burden
conditions
on
affected
individuals
overall.
Future
perspectives,
including
application
Artificial
Intelligence
principles
field,
related
found
so
far,
introduced.
