Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 20, 2024
Chemoradiotherapy is a crucial treatment modality for esophageal squamous cell carcinoma (ESCC). This study aimed to identify chemoradiotherapy sensitivity-related genes and analyze their prognostic value potential associations with the tumor microenvironment in ESCC.
Language: Английский
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(7)
Published: March 22, 2024
Abstract SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis tumour cells. However, underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three cell lines were treated with CCK‐8 assessed cytotoxicity. Transcriptome was performed on Illumina platform verified qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T‐SOD), Fe, glutathione (GSH) oxidized (GSSG) measured. induced death time‐ dose‐dependent, a more significant inhibitory effect MDA‐MB‐231 Fer‐1, GSH Vitamin C attenuated effects but not erastin. RNA‐Seq analysis revealed that treatment significantly enriched differentially expressed genes related ferroptosis. Furthermore, increased intracellular MDA, iron ion, GSSG levels while decreasing T‐SOD, (T‐GSH), levels.SBFI26 dose‐dependently up‐regulates expression HMOX1 ALOX12 at both gene levels, promoting Similarly, it increases SAT1, ALOX5, ALOX15, ALOXE3 CHAC1 that, downregulating NFE2L2 inhibit leads cellular accumulation fatty acids, triggers excess ferrous ions subsequent lipid peroxidation for inducing
Language: Английский
Citations
9
Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)
Published: March 1, 2025
Ferroptosis is an innovative concept defined as a distinct programmed cell death mode regulated by iron-dependent lipid peroxidation accumulation. This process governed numerous energy metabolites such fatty acids, amino acids and glucose, well iron homeostasis. In recent years, increasing studies have been devoted to the crucial effects of ferroptosis in immune cells during pathogenesis diseases infections, tumours autoimmune disorders. review summarises latest advancements T-cell ferroptosis, addresses key components mechanism T inflammatory conditions tumour progression, highlights potential target for treating related diseases. KEY POINTS: Ferroptosis-related mechanisms significantly affect biology CD4+ subsets are further involved Crosstalk between CD8+ induces microenvironment. Glutathione peroxidase 4 loss promotes regulatory enhance anti-tumour immunity.
Language: Английский
Citations
1
Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 3, 2025
Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.
Language: Английский
Citations
0
Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637
Published: March 1, 2025
Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.
Language: Английский
Citations
0
Clinical Breast Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
PubMed, Journal Year: 2024, Volume and Issue: 38(5), P. 598 - 607
Published: May 15, 2024
To investigate the feasibility of selenium-methylselenocysteine (SMC) to promote peripheral nerve regeneration and its mechanism action.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 19, 2024
Studies exploring the role of ferroptosis in pathogenesis breast cancer have proliferated over past decade, especially 2023, with a staggering 217 publications related studies. However, there are still significant gaps comprehensive scientometric analysis and mapping scientific studies, terms temporal study area tracking, principal investigators, emergence new hotspots. This aims to summarize development latest research results on ferroptosis-targeted treatment use bibliometric methods draw visual map explore future trends. On May 11, 2024, this updated progress 11 years by retrieving data from January 1, 2014, Web Science database. In research, many software including VOSviewer, chorddiag R Language Pack, Scimago Graphica, Citespace 6.3.R1, Cluster Profiler, enrichplot, ggplot2 Cytoscape, STRING online platform used make in-depth visualization measurement results. Statistical these showed that China accounted for 74.43% total publications, highlighting China's dominant relationship between cancer. Several institutions, Sun Yat-sen University, Zhejiang Shanghai Jiao Tong achieved impressive Efferth, Thomas is most prominent author field has highest number subfield oncology. clearly shows plays crucial triple-negative cancer, hepatocellular carcinoma, glioma, leukemia, mitochondrial disease, lymphoma, bladder tumors, lung adenocarcinoma, esophageal tumors. provides evaluation deepens our understanding current status targeting treating Thus, it helps researchers fields directions comprehensively extracting important information
Language: Английский
Citations
0
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 20, 2024
Chemoradiotherapy is a crucial treatment modality for esophageal squamous cell carcinoma (ESCC). This study aimed to identify chemoradiotherapy sensitivity-related genes and analyze their prognostic value potential associations with the tumor microenvironment in ESCC.
Language: Английский
Citations
0