Pain and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes significant global public health issue. Oxidative stress is pivotal factor in the pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as crucial antioxidant enzyme involved defense mechanisms ferroptosis pathways. This review systematically explores GPX4's functions across various pain models, including neuropathic, inflammatory, low back, cancer-related pain. Specifically, focus includes physiological roles, mechanisms, regulation ferroptosis, involvement signal transduction pathways, metabolic regulation. By summarizing current research, we highlight potential GPX4-targeted therapies management.

Language: Английский