Osteoporosis and chronic tendinopathy: a two-sample Bidirectional Mendelian randomization DOI Creative Commons
Hongfei Wu, Yu Cui, Yun Gao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract BACKGROUND The incidence of osteoporosis rises with advancing age, and it has emerged as a significant global public health issue, often presenting clinically symptoms such pain, kyphosis, reduced height, fractures.Chronic tendinopathy is common orthopedic disease, which mainly characterized by delayed difficult to heal, causing great pain patients. Preliminary epidemiological studies have investigated the potential association between chronic tendinopathy; however, definitive causal relationship yet be established. With increasing life expectancy an accelerating aging population, burden expected rise significantly, important implications for morbidity mortality.METHODS Instrumental variables were selected from IEU GWAS database summary statistics. Five different bone mineral density (BMD) sites—heel, total body, femoral neck, lumbar spine, ultradistal forearm BMD—along body BMD across five age groups (0–15, 15–30, 30–45, 45–60, over 60 years) utilized phenotypes. Achilles tendinitis, Bicipital Calcific tendinitis shoulder, Gluteal Patellar selected, Peroneal represent Chronic Multiple analytical methods employed comprehensively assess osteoporosis. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept 'leave-one-out' analysis, conducted verify robustness findings.RESULTS Mendelian Randomization analysis revealed sites shoulder; Additionally, MR demonstrated Heel BMD, Lumbar spine tendinitis. In examining age-related tendinopathy, relationships identified in 0–15 years, 45–60 years calcific shoulder.. all inverse no was observed. reliability these results confirmed through sensitivity analyses.CONCLUSION Osteoporosis may etiological factor observed particularly individuals 45 age. This suggests that patients underlying issue Therefore, routine screening recommended who present tendinopathy.

Language: Английский

Bioactive hydrogel formulations for regeneration of pathological bone defects DOI
Zuhao Li, Kaixuan Ren, Jiajia Chen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 686 - 714

Published: Feb. 17, 2025

Language: Английский

Citations

2
The potential application of electrical stimulation in tendon repair: a review DOI Creative Commons
Xiao Yu,

Yihong Shen,

Jie Cui

et al.

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 4, 2025

Language: Английский

Citations

2
The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro DOI

Noemi Mencarelli,

Dora Arena,

Marida Salamone

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Reactive oxygen species in tendon injury and repair DOI Creative Commons
Damir Kračun,

Agnes Görlach,

Jess G. Snedeker

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103568 - 103568

Published: Feb. 26, 2025

Reactive oxygen species (ROS) are chemical moieties that in physiological concentrations serve as fast-acting signaling molecules important for cellular homeostasis. However, their excess either due to overproduction or inability of the antioxidant system inactivate them results oxidative stress, contributing dysfunction and tissue damage. In tendons, which hypovascular, hypocellular, composed predominantly extracellular matrix (ECM), particularly collagen I, ROS likely play a dual role: regulating processes such inflammation, proliferation, ECM remodeling under conditions, while tendinopathy impaired healing when dysregulated. This review explores sources including NADPH oxidases mitochondria, role key adaptation mechanical load injury repair, also systemic conditions diabetes. addition, we integrate emerging perspective calcium signaling-mediated by mechanically activated ion channels-plays central tendon mechanotransduction daily loads. We propose overuse (overload) may lead hyperactivation channels, resulting chronically elevated intracellular levels amplify production stress. Although direct evidence linking channel hyperactivity, dysregulation, generation overload is currently circumstantial, this aims highlight these connections identify critical avenues future research. By framing within context both adaptive maladaptive responses load, provides comprehensive synthesis redox biology paving way work, development therapeutic strategies targeting enhance recovery resilience.

Language: Английский

Citations

0
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders DOI Creative Commons
Hongbin Sun, Chao Xu,

Zhilin Xiong

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Language: Английский

Citations

0
Design and development of titanium-coated implants with advanced antioxidant properties for enhanced regenerative repair of diabetic bone DOI

Kai Li,

Wenbo Geng,

Weikang Zhao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154522 - 154522

Published: Aug. 8, 2024

Language: Английский

Citations

2
Osteoporosis and chronic tendinopathy: a two-sample Bidirectional Mendelian randomization DOI Creative Commons
Hongfei Wu, Yu Cui, Yun Gao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract BACKGROUND The incidence of osteoporosis rises with advancing age, and it has emerged as a significant global public health issue, often presenting clinically symptoms such pain, kyphosis, reduced height, fractures.Chronic tendinopathy is common orthopedic disease, which mainly characterized by delayed difficult to heal, causing great pain patients. Preliminary epidemiological studies have investigated the potential association between chronic tendinopathy; however, definitive causal relationship yet be established. With increasing life expectancy an accelerating aging population, burden expected rise significantly, important implications for morbidity mortality.METHODS Instrumental variables were selected from IEU GWAS database summary statistics. Five different bone mineral density (BMD) sites—heel, total body, femoral neck, lumbar spine, ultradistal forearm BMD—along body BMD across five age groups (0–15, 15–30, 30–45, 45–60, over 60 years) utilized phenotypes. Achilles tendinitis, Bicipital Calcific tendinitis shoulder, Gluteal Patellar selected, Peroneal represent Chronic Multiple analytical methods employed comprehensively assess osteoporosis. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept 'leave-one-out' analysis, conducted verify robustness findings.RESULTS Mendelian Randomization analysis revealed sites shoulder; Additionally, MR demonstrated Heel BMD, Lumbar spine tendinitis. In examining age-related tendinopathy, relationships identified in 0–15 years, 45–60 years calcific shoulder.. all inverse no was observed. reliability these results confirmed through sensitivity analyses.CONCLUSION Osteoporosis may etiological factor observed particularly individuals 45 age. This suggests that patients underlying issue Therefore, routine screening recommended who present tendinopathy.

Language: Английский

Citations

0