The Critical Role of Autophagy and Phagocytosis in the Aging Brain DOI Open Access
Stephen C. Bondy,

Meixia Wu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 57 - 57

Published: Dec. 25, 2024

As the organism ages, there is a decline in effective energy supply, and this retards ability to elaborate new proteins. The consequences of are especially marked gradual brain function. senescence cells their constituent organelles ultimately cause aging entire nervous system. What less immediately obvious that also accompanied by failure catabolic events lead removal non-functional ineffective subcellular components. non-working cellular elements within essential order allow appearance fresh with full range capacities. Thus, maintenance operative mechanisms for dispersal failed tissue components important, its diminished capacity significant contributory factor onset progression age-related neurological disorder. This report discusses underlying autophagy phagocytosis how these can be adversely modulated as proceeds. means which recycling may reinstated aged considered.

Language: Английский

Therapeutic role of gut microbiota in lung injury-related cognitive impairment DOI Creative Commons
Yanxia Cheng,

Guangtao Hu,

Lin Deng

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Feb. 13, 2025

Lung injury can lead to specific neurocognitive dysfunction, and the “triple-hit” phenomenon may be key theoretical mechanism for progressive impairment of lung injury-related cognitive impairment. The brain communicate biologically through immune regulation pathway, hypoxic neural circuit, mitochondrial microbial influence, which is called “lung-brain axis.” gut microbiota a highly complex community microorganisms that reside in with via “gut-lung dysregulation migration pathogenic bacteria lung, directly or indirectly regulate response their metabolites, cause aggravate injury. interact “gut-brain influence function behavior pathway mechanisms, hypothalamic–pituitary–adrenal (HPA) axis regulation. Based on axis” axis,” combined mechanisms caused by injury, we proposed hypothesis. It states pathophysiological changes trigger series events such as disorder, inflammatory responses, changes, activate “lung-gut thus forming leads development deterioration This hypothesis provides more comprehensive framework studying understanding dysfunction context review proposes existence an interactive tandem network information exchange among gut, brain, referred “gut-lung-brain further explores potential multiple interactions We found there are many numerous factors interaction within impact functions related mediated hypothesis, direct translocation microbes modulation, vagal nerve activity, HPA regulation, others. As research deepens, based it discovered therapy significantly change pathogenesis process also relieve therapeutically modulate behavior. perspective new idea follow-up treatment microbiota.

Language: Английский

Citations

2
Gut microbiota and atrial cardiomyopathy DOI Creative Commons

Tingting Sun,

Beibei Song, Bo Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

Citations

0
Gut dysbiosis and leaky gut syndrome in moderately impaired amyotrophic lateral sclerosis patients DOI
Laura Comini, Davide Antonio Di Pietro, Adriana Olivares

et al.

European Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Targeting the Gut–Brain Axis with Plant-Derived Essential Oils: Phytocannabinoids and Beyond DOI Open Access
Luca Camarda, Laura Mattioli, Ivan Corazza

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1578 - 1578

Published: May 3, 2025

Background: The gut–brain axis (GBA) is a complex bidirectional communication system that links the gastrointestinal tract and central nervous system. Essential oils (EOs) have emerged as promising natural compounds capable of modulating this axis. Methods: A comprehensive analysis recent literature was conducted, focusing on studies investigating effects EOs GBA. Particular attention given to endocannabinoid system, role cannabis-derived EOs, other plant-based with potential neuroprotective gut microbiota-modulating effects. Results: Among analyzed, cannabis essential oil (CEO) gained for its interaction cannabinoid receptors (CBR1 CBR2), motility, immune responses, neurotransmission. While acute administration CEO reduces inflammation permeability, chronic use has been associated alterations in microbiota composition, potentially impairing cognitive function. Other such those from rosemary, lavender, eucalyptus, oregano, demonstrated neurotransmitter modulation, balance, neuroinflammation, supporting their therapeutic applications GBA-related disorders. Conclusions: demonstrate GBA through mechanisms including regulation, anti-inflammatory activity. At same time, phytocannabinoids offer value; long-term warrants caution due impacts microbiota. Future research should aim identify EO-based interventions can synergistically restore homeostasis mitigate neurodegenerative

Language: Английский

Citations

0
The Critical Role of Autophagy and Phagocytosis in the Aging Brain DOI Open Access
Stephen C. Bondy,

Meixia Wu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 57 - 57

Published: Dec. 25, 2024

As the organism ages, there is a decline in effective energy supply, and this retards ability to elaborate new proteins. The consequences of are especially marked gradual brain function. senescence cells their constituent organelles ultimately cause aging entire nervous system. What less immediately obvious that also accompanied by failure catabolic events lead removal non-functional ineffective subcellular components. non-working cellular elements within essential order allow appearance fresh with full range capacities. Thus, maintenance operative mechanisms for dispersal failed tissue components important, its diminished capacity significant contributory factor onset progression age-related neurological disorder. This report discusses underlying autophagy phagocytosis how these can be adversely modulated as proceeds. means which recycling may reinstated aged considered.

Language: Английский

Citations

0