The Role of Ferroptosis in Osteoporosis and Advances in Chinese Herbal Interventions DOI Creative Commons
Pan Li, Tianyang Xu,

Ao-xue Yu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 367 - 367

Published: April 2, 2025

OP, a systemic bone disorder marked by reduced mass and heightened fracture risk, poses significant global health burden, particularly among aging populations. Current treatments, including bisphosphonates calcium supplementation, are limited adverse effects incomplete efficacy. Emerging research highlights ferroptosis—an iron-dependent cell death driven lipid peroxidation—as critical contributor to OP pathogenesis, characterized dysregulated iron metabolism, oxidative stress, peroxide accumulation, which disrupt remodeling impairing osteoblast function enhancing osteoclast activity. This review elucidates the mechanistic interplay between ferroptosis subtypes (diabetic osteoporosis (DOP), glucocorticoid-induced (GIOP), postmenopausal (PMOP)) evaluates efficacy of Chinese herbal interventions in mitigating ferroptosis-driven loss. Key findings reveal that excess exacerbates peroxidation via Fenton reaction, while glutathione peroxidase 4 (GPX4) inactivation system Xc- inhibition amplify damage. In DIOP, hyperglycemia-induced ROS advanced glycation end products suppress osteogenesis, countered melatonin naringenin nuclear factor -related 2 (Nrf2)/GPX4 activation. GIOP involves dexamethasone-mediated GPX4 downregulation, mitigated exosomes through phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) signaling. PMOP estrogen deficiency-induced overload is alleviated aconitine icariin (ICA) kappa-light-chain-enhancer activated cells (NF-κB) signal transducer activator transcription 3 (STAT3) pathways. herbs, active compounds (quercetin, gastrodin, ICA, etc.) formulations (Bugu Shengsui Capsule, Erxian Decoction (EXD), etc.), regulate enhance antioxidant defenses (Nrf2/heme oxygenase 1(HO-1)), inhibit peroxidation, effectively restoring homeostasis. These underscore as pivotal mechanism progression highlight therapeutic promise herbs bridging traditional medicine with modern insights. Future should prioritize elucidating precise molecular targets, optimizing formulations, validating clinical address current gaps.

Language: Английский

The Role of Ferroptosis in Osteoporosis and Advances in Chinese Herbal Interventions DOI Creative Commons
Pan Li, Tianyang Xu,

Ao-xue Yu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 367 - 367

Published: April 2, 2025

OP, a systemic bone disorder marked by reduced mass and heightened fracture risk, poses significant global health burden, particularly among aging populations. Current treatments, including bisphosphonates calcium supplementation, are limited adverse effects incomplete efficacy. Emerging research highlights ferroptosis—an iron-dependent cell death driven lipid peroxidation—as critical contributor to OP pathogenesis, characterized dysregulated iron metabolism, oxidative stress, peroxide accumulation, which disrupt remodeling impairing osteoblast function enhancing osteoclast activity. This review elucidates the mechanistic interplay between ferroptosis subtypes (diabetic osteoporosis (DOP), glucocorticoid-induced (GIOP), postmenopausal (PMOP)) evaluates efficacy of Chinese herbal interventions in mitigating ferroptosis-driven loss. Key findings reveal that excess exacerbates peroxidation via Fenton reaction, while glutathione peroxidase 4 (GPX4) inactivation system Xc- inhibition amplify damage. In DIOP, hyperglycemia-induced ROS advanced glycation end products suppress osteogenesis, countered melatonin naringenin nuclear factor -related 2 (Nrf2)/GPX4 activation. GIOP involves dexamethasone-mediated GPX4 downregulation, mitigated exosomes through phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) signaling. PMOP estrogen deficiency-induced overload is alleviated aconitine icariin (ICA) kappa-light-chain-enhancer activated cells (NF-κB) signal transducer activator transcription 3 (STAT3) pathways. herbs, active compounds (quercetin, gastrodin, ICA, etc.) formulations (Bugu Shengsui Capsule, Erxian Decoction (EXD), etc.), regulate enhance antioxidant defenses (Nrf2/heme oxygenase 1(HO-1)), inhibit peroxidation, effectively restoring homeostasis. These underscore as pivotal mechanism progression highlight therapeutic promise herbs bridging traditional medicine with modern insights. Future should prioritize elucidating precise molecular targets, optimizing formulations, validating clinical address current gaps.

Language: Английский

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