Evaluation of Salivary Il-38 Levels in Periodontitis: A Cross-Sectional Study

Journal of Interferon & Cytokine Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

The goal of the current study was to assess levels salivary interleukin (IL)-38, IL-1β, and IL-10 in various periodontal clinical conditions. In total, 60 (20 healthy, 20 gingivitis, stage II–III, grade A–B periodontitis) subjects were included study. Demographic parameters recorded. Samples examined for IL-38, by means enzyme-linked immunosorbent assay. Results demonstrated that periodontitis group had significantly lower IL-38 (P < 0.05) than healthy group. Salivary did not differ between groups > 0.05). IL-1β gingivitis 0.001) 0.01) higher those present indicated level is decreased disease. results suggested a possible role inflammation process. Clarifying mechanisms inflammatory process may contribute development novel treatment strategies diseases.

Language: Английский

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Biomarkers in Gingival Diseases: Current Insights and Future Perspectives

Dentistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Periodontal diseases represent a spectrum of gingival disorders with multifaceted etiologies. Identifying and utilizing biomarkers in these conditions are essential for early detection, risk stratification, personalized therapeutic interventions. This chapter provides comprehensive overview biomarker research diseases, emphasizing clinical applications, detection methods, the potential saliva crevicular fluid as diagnostic vehicles. We also delve into emerging areas such microbiome-associated, epigenetic, metagenomic biomarkers. The underscores challenges associated validation, promise multi-marker panels improved accuracy, longitudinal studies to predict disease progression. As point-of-care technologies wearables pave way future diagnostics, innovative solutions like biosensors micro-electro-mechanical systems (MEMS) highlighted. encapsulates importance advancing discovery its pivotal role reshaping management.

Language: Английский

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Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 10, 2024

Language: Английский

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Biomarker research: From bench to publication…but gasping to reach chairside

Journal of Indian Society of Periodontology, Journal Year: 2023, Volume and Issue: 27(4), P. 339 - 340

Published: July 1, 2023

With the increase in research on biomarkers, their role existence, severity and pathogenicity of periodontal disease is becoming much more clearer with number studies being published these biomarkers. Biomarkers are objective quantifiable determinants normal biological or pathogenic processes can be measured accurately reproducibly.[1] The use biomarkers diagnosis management diseases could add immense value to our gold standard clinical measurements which current based. help overcoming limitations various indices used diagnosis. have been classified into five groups based function diverse stages: 1) Antecedent that identifying risk developing a disease, 2) Screening monitoring subclinical stage 3) Diagnostic diagnose, 4) Staging identify severity, 5) Prognostic predict course, duration, treatment efficacy outcome recurrence.[1,2] play critical prevention, disease. studied widely detect exposure by studying pathogen its virulence factors (biomarkers exposure); host response as result infectious agent measuring proinflammatory cytokines other proteins effect); recognise recognize susceptible individuals e.g., genetic susceptibility).[1,2] Endpoints trials either non-clinical. non-clinical endpoints. Poor selection endpoints makes elucidation application findings, challenging impossible.[3] problem is, despite plethora evidence generated innumerable results do not find way usage chairside assays. There deficiency confirmatory biomarker for it chair side assays practice. This attributed heterogenicity studies, basis definitions endpoint differences subject recruitment disparities sample management. Disparities collection, storage transportation methods, variations biochemical microbiological techniques study samples.[4] Pavloum et al. mentioned four steps research: (a) Preclinical exploratory likely Usually molecules having capacity differentiate between small samples from healthy diseased identified; (b) Development validation an assay measure interest independent sample; (c) Retrospective targeted large variability population ensure statistical precision; (d) continue show differentiate, progress next phase prospective trials.[5] development would require multiple multiphase procedure. A seven point checklist especially has suggested so heterogenicities reduced comparability this may achievable.[4] provides researchers indispensable fundamentals checkpoints, pertinent specific research.[4] talks about specificity material, clear health changes observed (being studied), population, sampling detection methodology, values sensitivity finally interpretation.[4] implementation criteria, might become possibility near future, that, wealth information available, utilized practice leading personalized treatment. These guidelines useful streamlining process reduce clutter waste.

Language: Английский

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Evaluation of Dental Materials and Oral Disease-Related Proteins in Dentistry: Efficacy of Electrophoresis as a Valuable Tool

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 3, 2023

Electrophoresis is a versatile technique that allows for the separation of molecules based on their size and electrical charge. In field dentistry, electrophoresis widely used in various applications, including analysis dental materials proteins associated with diseases oral cavity. Through electrophoresis, it possible to evaluate distribution filler particles within resin matrices, providing valuable information mechanical properties durability composite restorations. Furthermore, this has significantly contributed study implicated diseases, such as caries periodontitis. By effectively identifying separating these proteins, researchers gain deeper understanding mechanisms underlying conditions, facilitating development innovative therapeutic strategies. Overall, application dentistry emerged an indispensable tool comprehensive characterization diseases.

Language: Английский

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