Tectochrysin Alleviates Periodontitis by Modulating M2/M1 Macrophage Ratio and Oxidative Stress Via Nuclear Factor Kappa B/Heme Oxygenase-1/Nuclear Factor Erythroid 2-Related Factor 2 Pathway DOI

Ye Yin,

Yi-Ming Weng,

Zeyu Ma

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 29, 2024

Background Tectochrysin suppresses several diseases. In this study, we aimed to explore the effects of tectochrysin ona rat model periodontitis PDS).

Language: Английский

Macrophage Polarisation During Leishmania (Viannia) braziliensis Infection in Mice DOI

Marina Flóro e Silva,

Guilherme Augusto Sanches Roque, Lilian de Oliveira Coser

et al.

Parasite Immunology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 1, 2025

Leishmania (Viannia) braziliensis causes cutaneous and mucocutaneous leishmaniasis. Macrophages are host cells for parasite replication act as effector against the parasite. The two main macrophage phenotypes (M1 M2) their polarisation states have been implicated in infection despite scarce data on L. (V.) braziliensis. In this study, we investigated temporal spatial distribution predominance of M1 M2 macrophages during Balb/c mice. Animals were infected with promastigotes monitored 25 weeks. Histopathological evaluation footpad lesions, regional lymph nodes, spleen; cellularity; population quantification M1, by flow cytometry performed different tissues. results showed that after either strain lesions small non-ulcerated. dissemination parasites to tissues reinforced characteristic visualisation dermotropicL. proportion was significantly higher than macrophages. Overall, reported here confirm an intracellular parasite, promotes influences phenotype over time, researchers testing therapies based regulation should consider evidence.

Language: Английский

Citations

1
ENTR1 regulates periodontitis by modulating macrophage M1 polarization via AMPK activation DOI
Xi Wang,

Houda Gui,

Chenghang Liu

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 369, P. 123525 - 123525

Published: March 5, 2025

Language: Английский

Citations

0
Natural and induced immune responses in oral cavity and saliva DOI Creative Commons

Michele Matsuoka,

Salim Abraham Soria,

Julien Rodrigues Pires

et al.

BMC Immunology, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 18, 2025

Language: Английский

Citations

0
Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis DOI

Ziyi Xu,

Yue Wang,

Shuoshun Li

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 175, P. 214326 - 214326

Published: April 27, 2025

Language: Английский

Citations

0
Tectochrysin Alleviates Periodontitis by Modulating M2/M1 Macrophage Ratio and Oxidative Stress Via Nuclear Factor Kappa B/Heme Oxygenase-1/Nuclear Factor Erythroid 2-Related Factor 2 Pathway DOI

Ye Yin,

Yi-Ming Weng,

Zeyu Ma

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 29, 2024

Background Tectochrysin suppresses several diseases. In this study, we aimed to explore the effects of tectochrysin ona rat model periodontitis PDS).

Language: Английский

Citations

1