Editorial: Innovation in child and adolescent mental health interventions DOI Open Access
Paul Ramchandani, Tim Dalgleish, Joan L. Luby

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2023, Volume and Issue: 64(12), P. 1649 - 1651

Published: Nov. 28, 2023

We are living in a time when children and adolescents showing higher levels of mental health problems many countries, Child Adolescent Mental Health Services (CAMHS) most areas (where they exist at all) struggling with delivering services to all the young people families who need them. Many treatment centers respond by restricting scope their service, some excluding younger children, focusing on narrower diagnostic groupings, providing online information as holding strategy.

Language: Английский

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum DOI Creative Commons
Xiaotao Liang,

Yuewen Ding,

Xiaoyu Zhu

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 21, 2025

The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well various tissues organs. Circadian disturbance is major risk factor common comorbidity for mood disorders, especially anxiety depression. Bmal1 one fundamental protein genes that required to maintain rhythm. Recent research has revealed link between dysfunction depression, but underlying mechanisms remain be fully elucidated. This study aimed investigate how may lead anxiety- depression-like behaviors. Through behavioral tests, virus tracing, molecular biology techniques, we found neural connection from striatum. SCN lesions Bmal1flox/flox + pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions core body temperature rhythm, Importantly, these displayed altered expression patterns an upregulation Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within Microinjection TrkB inhibitor ANA-12 can effectively reverse These findings indicate contribute pathogenesis depression through BDNF-TrkB potentially mediated by projections SCN. gene represent novel therapeutic target disorders.

Language: Английский

Citations

1
Associations of evening-type and insomnia symptoms with depressive symptoms among youths DOI Creative Commons
Jianyu Que, Sijing Chen, Ngan Yin Chan

et al.

Sleep Medicine, Journal Year: 2024, Volume and Issue: 118, P. 81 - 87

Published: April 9, 2024

Evening-type and insomnia symptoms are significantly related to each other independently associated with depressive symptoms, yet few studies have examined the potential interaction between these two conditions. Therefore, we aimed examine associations of evening-type among Chinese youths, a specific focus on joint effects conditions symptoms.

Language: Английский

Citations

3
Dysregulation of CRY1 impairs brain thyroid hormone pathway and promotes anxiety-like behavior in male mice DOI
Baojiang Lv, Yuanyuan Liu, Yang Yu

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156292 - 156292

Published: May 1, 2025

Language: Английский

Citations

0
Network pharmacology- and molecular docking-based investigation on the mechanism of action of Si-ni San in the treatment of depression combined with anxiety and experimental verification in adolescent rats DOI Creative Commons
Zhiping Li,

Shimin Liang,

Xulan Cui

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Background The incidence rate of adolescent depression and anxiety has been increasing since the outbreak COVID-19, which there are no effective therapeutic drugs available. Si-ni San is commonly used in traditional Chinese medicine for treatment depression-like as well anxiety-like behavior, but its mechanism treating combined with during adolescence not yet clear. Methods Network pharmacology was to explore potential drug molecules related targets, molecular docking dynamics (MD) simulation were evaluate interaction between a model rats following behavioral tests biology verify results from network docking. Results As result, 256 active ingredients 1128 targets screened out. Among them, quercetin, Luteolin, kaempferol, 7-Methoxy-2-methyl isoflavone, formononetin showed be most ingredients; while STAT3, IL6, TNF, AKT1, TP53, IL1B, MAPK3, VEGFA, CASP3, MMP9 targets. AGE-RAGE signaling pathway diabetic complications, IL-17 pathway, HIF-1 PI3K-Akt TNF involved anti-inflammation processes, probable pathways regulated by San. Molecular MD compounds inflammation-associated revealed good binding abilities nobiletin PTGS2 PPARγ. In experiment rats, markedly suppressed early maternal separation (MS) chronic unpredictable mild stress (CUMS)-induced anxiety. qPCR further indicated that oxidative inflammatory response. Conclusion This study demonstrates anxiety- behavior induced MS CUMS can ameliorated improved inflammation hippocampus via targeting Nrf2 helping reveal

Language: Английский

Citations

2
Sleep as a Modifiable Risk Factor for Progression to Substance Use Disorder: A Review of Applicability in Adolescents with Early Life Adversity DOI
Nicholas A. Harris, Layla Banihashemi, Brant P. Hasler

et al.

Current Addiction Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

Citations

1
Relationship between social anxiety and sleep quality in depressed adolescents: the mediating role of internet addiction DOI Creative Commons
Yifan Ma, Jingya Li, Meng Xuan Zhang

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 10, 2024

This study investigated the association between social anxiety and sleep quality further explored potential mediating role of internet addiction in depressed adolescents.

Language: Английский

Citations

0
Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents DOI Creative Commons
Kara M. Duraccio,

Sarah Kamhout,

Isabella D. Wright

et al.

Frontiers in Sleep, Journal Year: 2023, Volume and Issue: 2

Published: Nov. 28, 2023

Introduction Aspects of circadian sleep health including alignment, phase, or chronotype may be related to mental outcomes in adolescents. Using novel and robust data collection methods, this study explored the relationship between adolescents' traits depression, anxiety, stress, emotional regulation. Methods Fifty-two healthy 14–18-year-olds (58% female; 94% European American) participated study. Across a 10-day period, participants completed wrist-worn actigraphy. Next, dim-light melatonin onset (DLMO) protocol where 12 saliva samples were collected over 6-h period measure phase. Circadian phase was calculated as duration time DMLO average across monitoring period. Social jetlag measured discrepancy times from weekday weekend. Participants Depression Anxiety Stress Scales (DASS-21), Emotion Regulation Questionnaire (ERQ), Morningness-Eveningness for Adolescents (MEQ). Following dichotomizing into clinically relevant groups (late vs. early aligned misaligned rhythms, minimal social presence jetlag, intermediate morningness eveningness chronotype), we conducted general linear models determine group differences (depression, expressive suppression, cognitive reappraisal) while controlling gender pubertal development. Results had large effect on depression symptoms adolescents, with adolescents later DLMO having significantly higher scores than those earlier ( p = 0.031). Chronotype medium but non-significant anxiety stress eveningness-tendencies morningness-tendencies 's 0.140 0.111, respectively). Conclusions In first ever using gold-standard methodologies examine observed that increased depressive compared Furthermore, who endorsed behaviors suggest tendencies have heightened stress/anxiety. These conclusions encourage future experimental research regarding topic help inform interventions aimed decrease

Language: Английский

Citations

1
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum DOI
Wei Xie,

Lai Xiao-tao,

Yuewen Ding

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 11, 2024

Abstract The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well various tissues organs. Circadian disturbance is major risk factor common comorbidity for mood disorders, especially anxiety depression. Bmal1 one fundamental protein genes that required to maintain rhythm. Recent research has revealed link between dysfunction depression, but underlying mechanisms remain be fully elucidated. This study aimed investigate how may lead depression-like behaviors. Through behavioral tests, virus tracing, molecular biology techniques, we found neural connection from striatum. SCN lesions Bmal1flox/flox+pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions core body temperature rhythm, anxiety- Importantly, these displayed altered expression patterns an upregulation Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within Microinjection TrkB inhibitor ANA-12 can effectively reverse These findings indicate contribute pathogenesis depression through BDNF-TrkB potentially mediated by projections SCN. gene represent novel therapeutic target disorders.

Language: Английский

Citations

0
Editorial: Innovation in child and adolescent mental health interventions DOI Open Access
Paul Ramchandani, Tim Dalgleish, Joan L. Luby

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2023, Volume and Issue: 64(12), P. 1649 - 1651

Published: Nov. 28, 2023

We are living in a time when children and adolescents showing higher levels of mental health problems many countries, Child Adolescent Mental Health Services (CAMHS) most areas (where they exist at all) struggling with delivering services to all the young people families who need them. Many treatment centers respond by restricting scope their service, some excluding younger children, focusing on narrower diagnostic groupings, providing online information as holding strategy.

Language: Английский

Citations

0