The wide spectrum of disease burden in atopic dermatitis—Implications for more holistic approaches? DOI Creative Commons
Alexander Salava

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(2), P. 245 - 246

Published: Jan. 24, 2024

In recent years, our understanding of the disease burden in atopic dermatitis (AD) has been increasing, and we have seen a wide range studies concentrating on clinical, psychological economic aspects disease. AD is one most frequent chronic skin conditions, thus, concepts its are relevant to every doctor, especially dermatologists. The work Eyerich et al.1 major addition this continuum research contains three specific strengths. First, well-conducted extensive study comprises validated real-life data, which many previous publications lacked. Second, there interesting subgroup analyses open discussions about causes asymmetrically distributed subsequently, targeted therapies. addition, third, was conducted multiple countries, enables systematic analysis relatively heterogenous populations. An old medical saying states that not be equated with burden.2 Every patient, whatever origin, background or severity, his her own illness, comprising all the, mentioned, key components but limited them. As different countries populations may differ, important question what as dermatologists can do lower it effectively, considering perpetual boundaries, economics resources.3, 4 past new medicaments introduced armamentarium treatments several more waiting follow.5 authors could show patients receiving systemic medications had significantly burden, gives hope for future. However, they also observed still exists substantial moderate-to-severe AD.6 What main factors each individual patient contribute burden? burden-targeting? How you manage based holistic approaches? These kinds questions practising dermatologist regularly ask himself herself. But nevertheless, remains condition maybe all, measures doctor's skills, view causes. al. succeeded make significant scientific contribution population-based multinational levels. It rests clinical put these observations into practice. None declare. Data sharing applicable article no datasets were generated analysed during current study.

Language: Английский

Link between obesity and atopic dermatitis: Does obesity predispose to atopic dermatitis, or vice versa? DOI Open Access
Shuyun Yang, Tingting Zhu,

Joan S. Wakefield

et al.

Experimental Dermatology, Journal Year: 2023, Volume and Issue: 32(7), P. 975 - 985

Published: April 7, 2023

Abstract Two serious health conditions, obesity and atopic dermatitis (AD), share some pathological features such as insulin resistance, leptin resistance inflammation, a growing body of evidence suggests link between AD. Obesity predisposes an individual to and/or worsens AD, whereas AD increases the risk obesity. AD's interactions are mediated by cytokines, chemokines immune cells. Obese individuals with more resistant anti‐inflammatory therapy, while weight loss can alleviate In this review, we summarize linking We also discuss pathogenic role in vice versa. Because connection these two mitigation one could possibly prevent development or other condition. Effective management enhance wellness both conditions. However, proper clinical studies warranted validate speculation.

Language: Английский

Citations

16
Filaggrin Gene Variants Among Patients With Atopic Dermatitis in Turkey: A Multicenter Study Investigating Its Relationship With Disease Severity and Clinical/Laboratory Findings DOI
Yasemin Erdem, Esen Özkaya, Yücel Erbilgin

et al.

Dermatitis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

0
Smoking (and Non-Smoking) DOI
Richard Brans

Published: Jan. 1, 2025

Citations

0
Allergens in Atopic Dermatitis DOI
Jiayan Zhang,

Guofang Li,

Qiuyang Guo

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease DOI

Nicolas Charles,

Ulrich Blank

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

Citations

0
Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis DOI Creative Commons

Julia Clabbers,

Celeste Boesjes,

Lotte S. Spekhorst

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(4), P. 1155 - 1161.e4

Published: Jan. 23, 2024

Background: Pathogenic variants in filaggrin (FLG) are associated with an increased risk of atopic dermatitis (AD).Objective: To evaluate the influence FLG on effectiveness dupilumab treatment AD. Methods:This prospective observational study included adult AD patients treated from BioDay Registry.FLG was analysed smMIP targeted sequencing.Novel mutations were confirmed by Sanger sequencing.Eczema Area and Severity Index (EASI), Investigator Global Assessment (IGA), Numeric Rating Scale (NRS) pruritus, Dermatology Quality Life (DLQI) Patient Oriented Eczema Measure (POEM) assessed at baseline, week 16 52.Results: Genetic analysis 285 showed bi-allelic pathogenic (FLG-/-) n=41 (14%), mono-allelic (FLG-/+) n=64 (23%) wild-type alleles (FLG+/+) n=180 (63%).Three novel found.We observed no clinically relevant differences EASI, IGA, NRS DLQI total POEM scores for without all time points.The FLG-/-group significantly higher flaking dryness (p<0.001and p=0.002, respectively) 52 (p<0.001 p=0.016, compared to FLG+/+, also significant FLG-/+, while delta nonsignificant. Conclusion:This suggests that not influenced variants.However, tended have a drier skin before during or alleles.

Language: Английский

Citations

3
Atopic dermatitis in Ethiopian children: a multicenter study of clinical severity, characteristics, and sociodemographic factors DOI Creative Commons
Abraham Getachew Kelbore, Wendemagegn Enbiale, Jacqueline Van Wyk

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 15, 2024

Background Atopic dermatitis (AD) is a chronic relapsing, pruritic, inflammatory skin disease. Assessing the characteristics and risk factors of severe AD central to healthcare workers’ understanding subsequent education patients for most optimal outcomes. The clinical are known vary depending on populations regions. has been well-documented in global North mainly Caucasian populations, while very few studies have conducted African residing Africa. This study assessed characteristics, severity, sociodemographic children with Southern Ethiopia. Methods A hospital-based cross-sectional was among 461 their caregivers four randomly selected hospitals Ethiopia from October 2022 September 2023. systematic sampling technique used enroll participants. Clinical profile data were collected by trained collectors. Scoring Dermatitis (SCORAD) index tool used. descriptive analysis performed characterize Univariate ordinary logistic regression identify associated SCORAD score. OR 95% show strength association, p- value &lt;0.05 declare level significance. Result Out AD-diagnosed children, 212 (46%) girls 249 (54%) boys. In sample pediatric patients, 149 (32.3%) exhibited mild AD, 231 (46.2%) presented moderate, 99 (21.5%) showed signs symptoms AD. All had itching. Dryness skin, excoriation, erythema, followed lichenification, observed signs. model, age onset disease [AOR CI 1.95 (1.3–2.94)], sex caregiver or family 0.61 (0.41–0.90)], atopy history 0.64 (0.44–0.93)], mother status [95% 2.45 (1.1–5.47)], use herbal medication 0.50 (0.33–0.79)] significantly severity Conclusion this study, 68% found moderate-to-severe Early onset, maternal education, familial history, caregiver, independent predictors children. We recommend further investigation into these variables potential serve as markers assess improve care management

Language: Английский

Citations

3
The Social and Home Environment: Impacts of Determinants of Health on Atopic Dermatitis, Pathways Toward Solutions, and Unique Considerations for Rural and Remote North American Indigenous Populations DOI

Rachel Asiniwasis,

Nickoo Merati,

Jordanna Roesler

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2023, Volume and Issue: 12(2), P. 290 - 299

Published: Nov. 25, 2023

Language: Английский

Citations

5
Time-dependent risk of atopic dermatitis following nontyphoidal Salmonella infection DOI
Renin Chang, Huiyuan Chen, Yao‐Min Hung

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: 100(1187), P. 649 - 656

Published: April 2, 2024

Abstract Background The pathogenesis of atopic dermatitis (AD) remains unclear. Nontyphoidal Salmonella (NTS) infection might trigger immune-mediated reactions. We aimed to examine NTS and the risk subsequent AD. Methods From 2002 2015, eligible patients (aged 0–100 years) with were identified. non-NTS groups matched at a 1:10 ratio on age sex. utilized conditional multivariable Cox proportional hazard models estimate adjusted (aHR) 95% confidence interval (CI) for AD development. Subgroup analyses conducted based age, sex, severity infection. landmark analysis explore time-dependent following NTS. Results In group (N = 6624), 403 developed After full adjustment demographics comorbidities, had higher than reference (aHR 1.217, CI 1.096–1.352). Age-stratified revealed that exhibited an elevated compared group, particularly among those aged 13–30 years 1.25, 1.017–1.559), individuals 31–50 1.388, 1.112–1.733), 51–70 1.301, 1.008–1.679), 71 over 1.791, 1.260–2.545). Severe was associated 2.411, 1.577–3.685). Landmark showed generally consistent findings. Conclusions Minimizing exposure may represent prospective strategy averting onset progression dermatitis.

Language: Английский

Citations

1
Associations between tobacco smoking status and patch test results—A cross‐sectional pilot study from the Information Network of Departments of Dermatology (IVDK) DOI Creative Commons
Sonja Molin, Richard Brans, Andrea Bauer

et al.

Contact Dermatitis, Journal Year: 2024, Volume and Issue: 91(3), P. 203 - 211

Published: May 22, 2024

Abstract Background Earlier studies suggested a potential association between tobacco smoking and nickel sensitization, but little is known about other contact allergens. Objectives To investigate the of status sensitizations as well subtypes dermatitis, to analyse sensitization profiles smokers. Patients Methods Within Information Network Departments Dermatology (IVDK), we performed cross‐sectional multicentre pilot study comprising 1091 patch‐tested patients from 9 departments, comparing 541 with history cigarette (281 current 260 former smokers) 550 never‐smokers. Results We could not confirm previously reported smoking. Moreover, allergens, including colophony, fragrance mix I, Myroxylon pereirae formaldehyde, were increased in smokers compared never Hand dermatitis (50.6% vs. 33.6%) occupational cause (36.2% 22.5%) significantly more frequent among never‐smokers shown by non‐overlapping 95% confidence intervals. Conclusions Although our does allow firm conclusion on whether contributes certain sensitizations, it confirms an hand cause.

Language: Английский

Citations

1