The wide spectrum of disease burden in atopic dermatitis—Implications for more holistic approaches? DOI Creative Commons
Alexander Salava

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(2), P. 245 - 246

Published: Jan. 24, 2024

In recent years, our understanding of the disease burden in atopic dermatitis (AD) has been increasing, and we have seen a wide range studies concentrating on clinical, psychological economic aspects disease. AD is one most frequent chronic skin conditions, thus, concepts its are relevant to every doctor, especially dermatologists. The work Eyerich et al.1 major addition this continuum research contains three specific strengths. First, well-conducted extensive study comprises validated real-life data, which many previous publications lacked. Second, there interesting subgroup analyses open discussions about causes asymmetrically distributed subsequently, targeted therapies. addition, third, was conducted multiple countries, enables systematic analysis relatively heterogenous populations. An old medical saying states that not be equated with burden.2 Every patient, whatever origin, background or severity, his her own illness, comprising all the, mentioned, key components but limited them. As different countries populations may differ, important question what as dermatologists can do lower it effectively, considering perpetual boundaries, economics resources.3, 4 past new medicaments introduced armamentarium treatments several more waiting follow.5 authors could show patients receiving systemic medications had significantly burden, gives hope for future. However, they also observed still exists substantial moderate-to-severe AD.6 What main factors each individual patient contribute burden? burden-targeting? How you manage based holistic approaches? These kinds questions practising dermatologist regularly ask himself herself. But nevertheless, remains condition maybe all, measures doctor's skills, view causes. al. succeeded make significant scientific contribution population-based multinational levels. It rests clinical put these observations into practice. None declare. Data sharing applicable article no datasets were generated analysed during current study.

Language: Английский

Predisposition to conjunctivitis and male sex reduces drug survival of dupilumab in adults and adolescents. DOI
Luca Mastorino,

Irene Richiardi,

Federica Gelato

et al.

Expert Opinion on Biological Therapy, Journal Year: 2024, Volume and Issue: 24(8), P. 863 - 868

Published: June 24, 2024

There are currently limited data on dupilumab drug survival (DS), especially factors possibly associated with discontinuation.

Language: Английский

Citations

1
Causal Effects of Asthma on Upper Airway Diseases and Allergic Diseases: A Two-Sample Mendelian Randomization DOI
Zengxiao Zhang, Gongfei Li,

Shizhe Zhou

et al.

International Archives of Allergy and Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Aug. 6, 2024

Asthma is associated with upper airway diseases and allergic diseases; however, the causal effects need to be investigated further. Thus, we performed this two-sample Mendelian randomization (MR) analysis explore measure of asthma on rhinitis (AR), vasomotor (VMR), conjunctivitis (AC), atopic dermatitis (AD), urticaria (AU).

Language: Английский

Citations

1
Keratosis pilaris: an update and approach to management DOI
Nilesh Kodali, Viral Patel, Robert A. Schwartz

et al.

Italian Journal of Dermatology and Venereology, Journal Year: 2023, Volume and Issue: 158(3)

Published: May 11, 2023

Keratosis pilaris (KP) is a common, hyperkeratotic skin condition characterized by small, folliculocentric papules with variable perifollicular erythema. We provide an updated review on the pathogenesis, clinical manifestations, and management of this often annoying, finding. KP represents family follicular disorders, which simplex far most common. Other variants rare subtypes include keratosis rubra, erythromelanosis follicularis faciei et colli, spectrum atrophicans. Inherited mutations FLG gene ABCA12 have been implicated etiologically. may be associated ichthyosis vulgaris palmar hyperlinearity, but less likely atopic dermatitis. Some potential differential diagnoses for lichen spinulosus, phrynoderma, vulgaris, trichostasis spinulosa. General cutaneous measures such as hydrating skin, avoiding long baths or showers, using mild soaps cleansers should recommended. Topical keratolytic agents are first-line therapy, followed topical retinoids corticosteroids. Recent options variety lasers microdermabrasion if patient refractory to therapy.

Language: Английский

Citations

3
A Retrospective Analysis of Risk Factors for Atopic Dermatitis Severity DOI
Min Luo, Huichun Su, Jinger Lin

et al.

Dermatitis, Journal Year: 2023, Volume and Issue: 35(S1), P. S81 - S90

Published: April 26, 2023

Atopic dermatitis (AD) has the highest burden of any skin disease; however, severity-associated factors remain unclear.

Language: Английский

Citations

2
Association between atopic disease and vaccination granulomas: A nested case–control study DOI
Stine Skovbo Hoffmann, Emilia Myrup Thiesson, Jeanne D. Johansen

et al.

Contact Dermatitis, Journal Year: 2023, Volume and Issue: 90(4), P. 411 - 419

Published: Dec. 7, 2023

Abstract Background Vaccination granulomas are observed in 1% of all children vaccinated with an aluminium‐adsorbed vaccine. Most also have aluminium contact allergy (CA). CA and atopic diseases both highly prevalent among may be associated. Objective To investigate the association between vaccination dermatitis (AD), asthma rhinitis children. Methods We sourced a cohort Danish born from 2009 to 2017 conducted nested case–control study, cases defined as granulomas, matched controls 1:10 on sex, socioeconomic class, gestational age season birth. All were vaccines followed until their second birthday. used conditional logistic regression estimate odds ratios (ORs). Results The study included 2171 21 710 controls. Children diagnosis AD had significantly higher risk granuloma (OR 1.50, 95% confidence intervals [CI] 1.25–1.80). No significant was found or rhinitis. even additional sensitivity‐analysis, following fourth birthday 2.71, CI 2.36–3.11). Conclusion associated but not other diseases, within first 2 4 years life.

Language: Английский

Citations

2
Disease burden of moderate–severe atopic dermatitis by use of systemic treatment: Results from the Danish Skin Cohort DOI
Ida Vittrup, Anne Grete Frøstrup, Susanne Thiesen Gren

et al.

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2023, Volume and Issue: 37(5)

Published: Jan. 23, 2023

Language: Английский

Citations

1
Real‐world treatment patterns of Finnish adult patients with atopic dermatitis: From topicals to systemic therapy DOI Creative Commons
Ville Kiiski, Johanna Vikkula, Liisa Ukkola‐Vuoti

et al.

JEADV Clinical Practice, Journal Year: 2023, Volume and Issue: 2(4), P. 819 - 829

Published: Sept. 8, 2023

Abstract Background Atopic dermatitis (AD) is a chronic skin condition with varying persistence and intensity. In mild cases, topical therapies usually suffice to prevent flares. However, systemic treatment options may be required in the moderate severe forms of AD. lack comprehensive real‐world data, exhaustive descriptions overall practice AD are still missing. Objectives The objective this study was describe patterns Finland. Further, aimed provide an in‐depth understanding Methods This retrospective registry utilized nationwide data from both primary secondary healthcare electronic health records. All patients (128,428) diagnosis code or reimbursement for medication 2005 2019 were collected. Treatments, switches, time next (TTNT) investigated. Severity assessed based on data. Results majority (83%) had used at least one during time. Irrespective severity, amounts reimbursed topicals appeared low (topical calcineurin inhibitors 66 g, corticosteroids 110 g emollients 1 kg per year) when compared care recommendations. Most managed their options. Only 7.2% purchased medication, which methotrexate cyclosporine most common TTNT ranged several years up decades, median 4 9 months depending selected therapy. Conclusions use rare population, detected among receiving low. amount suggests potentially suboptimal levels basic

Language: Английский

Citations

1
The wide spectrum of disease burden in atopic dermatitis—Implications for more holistic approaches? DOI Creative Commons
Alexander Salava

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(2), P. 245 - 246

Published: Jan. 24, 2024

In recent years, our understanding of the disease burden in atopic dermatitis (AD) has been increasing, and we have seen a wide range studies concentrating on clinical, psychological economic aspects disease. AD is one most frequent chronic skin conditions, thus, concepts its are relevant to every doctor, especially dermatologists. The work Eyerich et al.1 major addition this continuum research contains three specific strengths. First, well-conducted extensive study comprises validated real-life data, which many previous publications lacked. Second, there interesting subgroup analyses open discussions about causes asymmetrically distributed subsequently, targeted therapies. addition, third, was conducted multiple countries, enables systematic analysis relatively heterogenous populations. An old medical saying states that not be equated with burden.2 Every patient, whatever origin, background or severity, his her own illness, comprising all the, mentioned, key components but limited them. As different countries populations may differ, important question what as dermatologists can do lower it effectively, considering perpetual boundaries, economics resources.3, 4 past new medicaments introduced armamentarium treatments several more waiting follow.5 authors could show patients receiving systemic medications had significantly burden, gives hope for future. However, they also observed still exists substantial moderate-to-severe AD.6 What main factors each individual patient contribute burden? burden-targeting? How you manage based holistic approaches? These kinds questions practising dermatologist regularly ask himself herself. But nevertheless, remains condition maybe all, measures doctor's skills, view causes. al. succeeded make significant scientific contribution population-based multinational levels. It rests clinical put these observations into practice. None declare. Data sharing applicable article no datasets were generated analysed during current study.

Language: Английский

Citations

0