An Unusual Presentation of Plantar Psoriasis: A Case Report DOI Open Access

Marta Natário Baptista,

Paul Florez Cardoso,

S. de Sousa

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

Plantar psoriasis is a chronic inflammatory skin disorder, typically characterized by erythematous plaques with thick silvery scales localized on the soles. This condition can significantly impair patients' quality of life, particularly through pain and mobility challenges. It considered subtype plaque but presents unique diagnostic therapeutic challenges due to its specific location. We report case 44-year-old female bilateral burning scaling feet, initially misdiagnosed treated for fungal infections without success. Despite persistent symptoms, dermatological consultation was delayed three years. Upon reassessment, she presented scaly lesions elbows feet. Treatment topical betamethasone calcipotriol led partial resolution plantar not elbow lesions. Following comprehensive evaluation, patient diagnosed maintained therapy, avoiding systemic treatments. Her management highlights importance accurate diagnosis timely specialist referral. illustrates in diagnosing psoriasis, when overlapping other conditions. A conservative treatment approach steroids proved effective managing symptoms. The patient's referral underscores need prompt care mitigate prolonged discomfort. Additionally, comorbidities like anxiety depression may exacerbate emphasizing integrated that addresses both physical psychological aspects. emphasizes necessity diagnosis, early care, multidisciplinary conditions such as psoriasis. Further research warranted explore interplay between factors improve outcomes.

Language: Английский

Peau et psychisme : le vrai et le faux DOI
L. Misery

Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Citations

0
Pruritus and Neuropsychiatric Symptoms Among Patients with Darier Disease—An Overlooked and Interconnected Challenge DOI Open Access
Grace Xiong, Muskaan Sachdeva, Gil Yosipovitch

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1818 - 1818

Published: March 8, 2025

(1) Background: Darier disease (DD) is a rare autosomal dominant disorder caused by mutations in ATP2A2, gene that encodes the sarco(endo)plasmic reticulum calcium-ATPase 2 enzyme, which disrupts calcium homeostasis keratinocytes. Pruritus, frequently overlooked symptom DD, can lead to physical and emotional complications, especially patients with DD who are genetically predisposed psychiatric comorbidities. (2) Methods: This study aimed analyze pruritus other related symptoms explore their correlation neuropsychiatric conditions, psychological challenges, severity, body surface area (BSA) involvement through retrospective review of tertiary center. (3) Results: Data from 76 (equal gender distribution, mean age 44 years) revealed prevalence 90.8%, surpassing such as pain (34.3%) malodor (43.4%). Burning sensations due lesions were significantly correlated diagnosis comorbid conditions (p = 0.047) medication use 0.019). While severity %BSA involvement, findings not statistically significant. Patients reporting had higher Dermatology Life Quality Index score (2.4 ± 1.0), defined presence itch, soreness, pain, or stinging, than those did (1.5 0.6), indicating accurate reporting. (4) Conclusions: In conclusion, striking majority experience pruritus, among severe disease, greater skin involvement. Clinicians should recognize key therapeutic target adopt comprehensive treatment approaches both address comorbidities added burden DD.

Language: Английский

Citations

0
The effect of IL17 antibody in psoriasis on brain structural morphology reveals significant changes in the precuneus DOI
Hideki Mochizuki, Sarah G Brooks, Rami H. Mahmoud

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Adipokines in multiple sclerosis: Immune dysregulation, neuroinflammation, and therapeutic opportunities DOI
Elham Moases Ghaffary, Geir Bjørklund, Ramesa Shafi Bhat

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103825 - 103825

Published: April 1, 2025

Language: Английский

Citations

0
A Narrative Review on Stress and Itch: What We Know and What We Would Like to Know DOI Open Access

Nicole Khalil,

Giulia Coscarella, Firdaus S. Dhabhar

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6854 - 6854

Published: Nov. 14, 2024

Itch is one of the most prevalent symptoms experienced by patients with inflammatory skin conditions, yet it also debilitating. Patients suffering from chronic itch have been found to significantly higher stress levels compared those not experiencing itch. In fact, recent studies revealed a bidirectional relationship between and itch, where each condition worsens other. This thought be driven vicious itch–scratch cycle, which fueled underlying inflammation. The precise molecular pathways mediators involved, however, remain unclear. narrative review discusses existing research on outlines future directions that will necessary advance our understanding treatment these conditions. Given effective management both often requires combined approach, further investigation into their shared mechanisms essential for identifying successful therapies improving patient outcomes.

Language: Английский

Citations

3
Integrative Treatment Approaches with Mind–Body Therapies in the Management of Atopic Dermatitis DOI Open Access

Gil Yosipovitch,

Ludivine Canchy, Bárbara Roque Ferreira

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5368 - 5368

Published: Sept. 11, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin disease with complex pathophysiology characterized by intense pruritus, often associated psychological stress and atopic non-atopic comorbidities that significantly reduce quality of life. The aspects AD the interaction between mind body via skin–brain axis have led to an interest in mind–body therapies (MBT). aim this article is, therefore, reinforce importance psychodermatological care AD. We performed focused literature review on holistic practices or integrative MBT AD, including education, cognitive behavioral therapy, habit reversal, meditation, mindfulness, hypnotherapy, eye movement desensitization reprocessing, biofeedback, progressive muscle relaxation, autonomous sensory meridian response, music massage, touch therapy. A multidisciplinary approach MBT, addition conventional pharmacologic antipruritic therapies, break itch–scratch cycle may improve outcomes well-being. Although there paucity rigorously designed trials, evidence shows potential benefits pain, stress, anxiety, depressive symptoms, sleep quality. Relaxation various interventions, such as reversal therapy for replacing harmful scratching massaging emollient ‘plus’, urge scratch, while education adherence therapies.

Language: Английский

Citations

2
New insights to the mind–body connection: The importance of the brain–gut microbiome for inflammatory skin diseases DOI Creative Commons
Florence Dalgard, Anthony Bewley

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(5), P. 784 - 785

Published: April 25, 2024

The dualism between physical disease and mental health is increasingly being deconstructed. World Health Organization, the Psychiatric Association other international bodies have taken action to focus on this issue not only in research but also education service development.1 There strong evidence for shared risk factors chronic (including inflammatory skin diseases) affective disorders such as alcohol consumption, tobacco smoking, reduced activity, poor diet sleep hygeine. consequences of stressful life events across a lifespan several diseases understood.2 And there increasing presence neuroinflammation an independent cause psychosocial comorbidities patients who longstanding psoriasis.3 psychological distress experienced by with psoriasis may be, at least part, caused solely consequence 'stress' living visible condition. work Biazus Soares et al. present issue,4 discusses various axes which connect brain skin: hormonal via hypothalamic–pituitary–adrenocortical axis, directly cutaneous neurons; neuroinflammatory pathways inherent brain–skin immune connections. Recently, has sharpened link gut–brain implicated just important factor development exacerbation disease, (and interestingly) prolongation depression live authors indicate that disruption junction integrity intestinal epithelium containing signalling cascade affecting blood–brain barrier function neuroinflammation. colleagues are keen point out, though, multiple biological be relevant generation both illness diseases. growing common mechanisms stress, well conditions through neuroimmunological axis. axis play role, along already established direct neuronal pathways, more recently recognized pathways.5 What clear further studies needed explore these issues particularly as, patients, so important. implication study supports necessity multidisciplinary approach managing our patients' pychological disease. declare no conflict interest regarding publication. Data sharing applicable article datasets were generated or analysed during current study.

Language: Английский

Citations

1
The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study DOI

Keyi Zhang,

Mingwei Zeng,

Lei Li

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship different types of dermatoses is lacking. This study aimed to investigate negative through Mendelian randomization (MR) analysis.

Language: Английский

Citations

1
An Unusual Presentation of Plantar Psoriasis: A Case Report DOI Open Access

Marta Natário Baptista,

Paul Florez Cardoso,

S. de Sousa

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

Plantar psoriasis is a chronic inflammatory skin disorder, typically characterized by erythematous plaques with thick silvery scales localized on the soles. This condition can significantly impair patients' quality of life, particularly through pain and mobility challenges. It considered subtype plaque but presents unique diagnostic therapeutic challenges due to its specific location. We report case 44-year-old female bilateral burning scaling feet, initially misdiagnosed treated for fungal infections without success. Despite persistent symptoms, dermatological consultation was delayed three years. Upon reassessment, she presented scaly lesions elbows feet. Treatment topical betamethasone calcipotriol led partial resolution plantar not elbow lesions. Following comprehensive evaluation, patient diagnosed maintained therapy, avoiding systemic treatments. Her management highlights importance accurate diagnosis timely specialist referral. illustrates in diagnosing psoriasis, when overlapping other conditions. A conservative treatment approach steroids proved effective managing symptoms. The patient's referral underscores need prompt care mitigate prolonged discomfort. Additionally, comorbidities like anxiety depression may exacerbate emphasizing integrated that addresses both physical psychological aspects. emphasizes necessity diagnosis, early care, multidisciplinary conditions such as psoriasis. Further research warranted explore interplay between factors improve outcomes.

Language: Английский

Citations

0