IWR-1 attenuates the promotional effect of IL-36γ in a mouse model of psoriasis DOI Creative Commons
Wenming Wang, Yimeng Gao, Xiaofeng Zheng

et al.

BMC Immunology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 23, 2024

Psoriasis is a chronic inflammatory skin disease. The Wnt/β-catenin signaling pathway essential for the regulation of adult stem cells, homeostasis, and tissue regeneration; however, relationship between this interleukin (IL)-36γ in pathogenesis psoriasis remains unclear. In study, psoriasiform model mice were established using imiquimod (IMQ) induction. Hematoxylin eosin (H&E) staining was used to evaluate pathological morphologies, while immunohistochemistry verify expression patterns β-catenin factors IL-6, IL-17 A, interferon (IFN)-γ. IL-36γ treatment increased area severity index scores, enhanced proliferation keratinocytes IMQ-induced psoriatic mice. effects on lesions epidermal hyperplasia partly inhibited by IWR-1, which an inhibitor pathway. Furthermore, levels proinflammatory cytokines molecules involved mouse skin, including IFN-γ, β-catenin, Dickkopf-1 (DKK1), upregulated with IL-36γ. Consistently, response alleviated IWR-1. Taken together, our findings suggested that inhibition may be useful alleviation IL-36γ-induced psoriasis-like lesions.

Language: Английский

Anti-IL 17 biologics and pyoderma gangrenosum – therapeutic or causal? DOI

Anna Wanzenberg,

Elise Keshock,

Naveed Sami

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 13, 2025

Language: Английский

Citations

1
Off-Label Use of Spesolimab in Dermatology: A Systematic Review DOI
Siddhartha Sood,

Jihad Waked,

Nabil Merchant

et al.

Journal of Cutaneous Medicine and Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Association Between Pyoderma Gangrenosum and Cutaneous Malignancies: A Systematic Review DOI

Shireen Dumont,

Eric McMullen, Dea Metko

et al.

Journal of Cutaneous Medicine and Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
Generalisierte pustulöse Psoriasis DOI
Sascha Gerdes

hautnah dermatologie, Journal Year: 2025, Volume and Issue: 41(S1), P. 34 - 39

Published: Feb. 1, 2025

Citations

0
Oxidative Stress and Generalised Pustular Psoriasis: Report of d‐ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy DOI Creative Commons
Chisato Tawada,

Yoji Ueda,

Yoko Mizutani

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(3)

Published: March 1, 2025

Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed diacron-reactive metabolite (d-ROM) test and biological antioxidant potential (BAP) on sera from nine patients with active GPP who were hospitalised treated at our hospital, including three pregnancy (PPP). The serum d-ROM BAP levels evaluated before treatment 1 month treatment. also immunostaining 4-hydroxy-2-nonenal (4-HNE) skin tissues. In patients, average significantly reduced (reduced to 343.0 ± 82.1 U.Carr 423.2 95.0 U.Carr, p = 0.005). Generalised Pustular Psoriasis Area Severity Index (GPPASI) score correlated (r 0.57, 0.10), suggesting that those reflect disease severity. normal pregnancy, values known increase mid-term late-term. increased when worsened case PPP. Immunohistochemical staining 4-HNE was positive for subcorneal pustules, neutrophils, cytoplasm epidermal keratinocytes, especially upper layers. Our findings indicate may play an important role

Language: Английский

Citations

0
Unraveling the causal associations between systemic cytokines and six inflammatory skin diseases DOI

Waner Liu,

Xu Zhang, Xiang Chen

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 185, P. 156810 - 156810

Published: Dec. 3, 2024

Language: Английский

Citations

1
Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease DOI Creative Commons
Masashi Akiyama

The Journal of Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Generalized pustular psoriasis (GPP) is a severe autoinflammatory keratinization disease (AiKD) characterized by acute flares of widespread sterile pustules and high fever. GPP potentially life-threatening. Recently clarified genetic predisposing factors for suggest that the excessive activation innate immune pathways in skin, including interleukin (IL)-1 IL-36 signaling, plays significant role pathogenesis. IL36RN, CARD14, AP1S3, MPO, SERPINA3, BTN3A3, MEFV have been identified as GPP-related genes. The pathogenesis provoked variants these seven genes tightly associated with resulting autoinflammation skin. Various biologics, inhibitors tumor necrosis factor, IL-17, IL-23 pathways, are used treatments GPP. new understanding background GPP, mentioned above, indicates predominantly related to immunity autoinflammation. In this context, inflammatory IL-1 clinical practice investigated potential future therapies.

Language: Английский

Citations

1
Insights into the Pathogenesis of Pyoderma Gangrenosum DOI

Sarah Becker,

Morgan Vague, Alex G. Ortega‐Loayza

et al.

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Improvement of acute phase symptoms of pemphigus foliaceus with Spesolimab. DOI Creative Commons

Shohei Iida,

Ken Muramatsu,

Ayaka Mizuno

et al.

JAAD Case Reports, Journal Year: 2024, Volume and Issue: 55, P. 40 - 44

Published: Sept. 19, 2024

Language: Английский

Citations

0
IWR-1 attenuates the promotional effect of IL-36γ in a mouse model of psoriasis DOI Creative Commons
Wenming Wang, Yimeng Gao, Xiaofeng Zheng

et al.

BMC Immunology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 23, 2024

Psoriasis is a chronic inflammatory skin disease. The Wnt/β-catenin signaling pathway essential for the regulation of adult stem cells, homeostasis, and tissue regeneration; however, relationship between this interleukin (IL)-36γ in pathogenesis psoriasis remains unclear. In study, psoriasiform model mice were established using imiquimod (IMQ) induction. Hematoxylin eosin (H&E) staining was used to evaluate pathological morphologies, while immunohistochemistry verify expression patterns β-catenin factors IL-6, IL-17 A, interferon (IFN)-γ. IL-36γ treatment increased area severity index scores, enhanced proliferation keratinocytes IMQ-induced psoriatic mice. effects on lesions epidermal hyperplasia partly inhibited by IWR-1, which an inhibitor pathway. Furthermore, levels proinflammatory cytokines molecules involved mouse skin, including IFN-γ, β-catenin, Dickkopf-1 (DKK1), upregulated with IL-36γ. Consistently, response alleviated IWR-1. Taken together, our findings suggested that inhibition may be useful alleviation IL-36γ-induced psoriasis-like lesions.

Language: Английский

Citations

0