Novel amide derivatives containing an 1,2,4‐oxadiazole moiety as potential SDH inhibitors: design, synthesis, and nematicidal activity DOI
Mei Zhu, Tingting Du, Yan Zhang

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract BACKGROUND The pine wilt disease (PWD) caused by Bursaphelenchus xylophilus is considered the ‘cancer’ of trees, and protecting forests from destructive impact nematode remains a significant challenge. Chemical control one most effective methods for managing plant nematodes. Developing new nematicides an strategy urgent need management. RESULTS Amide derivatives containing 1,2,4‐oxadiazole were designed synthesized through scaffold‐hopping strategy. Some target compounds exhibited nematicidal activities. For example, compound F3 showed half‐maximal lethal concentration (LC 50 ) value 3.63 mg/L against . Compound not only significantly inhibited hatching eggs, but also reduced feeding, reproduction, motility Additionally, induced accumulation lipofuscin, lipids, reactive oxygen species (ROS) in , leading to harmful oxidative stress responses. severe damage intestinal barrier, led shrinkage surface. Interestingly, favorable interaction pattern with succinate dehydrogenase (SDH) was similar fluopyram SDH. may inhibit activity SDH, blockage electron transfer respiratory chain, thereby resulting death. CONCLUSION can serve as potential lead SDH inhibitor, further molecular structure optimization discover future. © 2025 Society Industry.

Language: Английский

Novel amide derivatives containing an 1,2,4‐oxadiazole moiety as potential SDH inhibitors: design, synthesis, and nematicidal activity DOI
Mei Zhu, Tingting Du, Yan Zhang

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract BACKGROUND The pine wilt disease (PWD) caused by Bursaphelenchus xylophilus is considered the ‘cancer’ of trees, and protecting forests from destructive impact nematode remains a significant challenge. Chemical control one most effective methods for managing plant nematodes. Developing new nematicides an strategy urgent need management. RESULTS Amide derivatives containing 1,2,4‐oxadiazole were designed synthesized through scaffold‐hopping strategy. Some target compounds exhibited nematicidal activities. For example, compound F3 showed half‐maximal lethal concentration (LC 50 ) value 3.63 mg/L against . Compound not only significantly inhibited hatching eggs, but also reduced feeding, reproduction, motility Additionally, induced accumulation lipofuscin, lipids, reactive oxygen species (ROS) in , leading to harmful oxidative stress responses. severe damage intestinal barrier, led shrinkage surface. Interestingly, favorable interaction pattern with succinate dehydrogenase (SDH) was similar fluopyram SDH. may inhibit activity SDH, blockage electron transfer respiratory chain, thereby resulting death. CONCLUSION can serve as potential lead SDH inhibitor, further molecular structure optimization discover future. © 2025 Society Industry.

Language: Английский

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