International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10370 - 10370
Published: Sept. 26, 2024
With
the
escalating
prevalence
of
hair
loss,
demand
for
effective
loss
treatment
has
surged.
This
study
evaluated
effects
hot
water
extract
Hydrangea
serrata
(Thunb.)
Ser.
leaf
(WHS)
on
growth,
employing
cell
cultures,
mice,
and
human
skin
organoid
models.
Both
WHS
hydrangenol
were
found
to
enhance
5α-reductase
inhibitory
activity.
have
been
shown
stimulate
dermal
papilla
(DPC)
potentially
through
factors
like
keratinocyte
growth
factor
(KGF),
fibroblast
10
(FGF10),
transforming
factor-β1
(TGF-β1).
They
also
elevated
expression
levels
keratin
genes
(K31
K85)
ceramide
synthase
(CerS3)
gene,
crucial
clinical
indicators
health.
Furthermore,
they
exhibited
notable
anti-inflammatory
anti-androgenic
properties
by
reducing
tumor
necrosis
factor-α
(TNF-α)
androgen
signaling
molecules,
including
receptor
(AR)
dickkopf-1
(DKK-1)
gene
expression.
Oral
administration
C57BL/6
mice
3
weeks
confirmed
its
growth-promoting
effects,
improving
parameters
without
significant
changes
in
weight.
Additionally,
a
model,
was
formation
augment
follicle
markers.
These
findings
position
as
promising
nutraceutical
promoting
health,
evidenced
efficacy
both
vitro
vivo
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 225 - 225
Published: Feb. 4, 2025
Hempseeds,
from
the
Cannabis
sativa
plant,
and
its
derivates
are
a
versatile
food
option
for
various
dietary
preferences.
Due
to
their
aminoacidic
profile,
researchers
have
studied
presence
of
bioactive
peptides
in
hempseed
proteins.
In
this
study,
water-soluble
fraction
protein
was
extracted,
derived
were
analyzed.
The
investigation
focused
on
biological
function,
particularly
antioxidant
activity.
Several
functions
arisen,
such
as
angiotensin-converting
enzyme
inhibition
activity,
dipeptidyl-peptidase
IV,
III
inhibition,
ubiquitin-mediated
proteolysis
activation.
hydrolysates
show
greater
2,2-azinobis-[3-ethylbenzothiazoline-6-sulphonic
acid
(ABTS)
radical
scavenging
activity
compared
proteins
(97.95
±
4.48
versus
81.04
10.63).
Furthermore,
impact
these
U937
cell
line
evaluated
assess
viability
potential
role
modulating
inflammation
associated
with
gastrointestinal
autoimmune
diseases.
Protein
treatment
resulted
significant
reduction
viability,
opposed
hydrolysates,
which
did
not
affect
it.
Gels,
Journal Year:
2023,
Volume and Issue:
9(12), P. 921 - 921
Published: Nov. 22, 2023
Plant-based
meat
analogues
are
food
products
made
from
vegetarian
or
vegan
ingredients
that
intended
to
mimic
taste,
texture
and
appearance
of
meat.
They
becoming
increasingly
popular
as
people
look
for
more
sustainable
healthy
protein
sources.
Furthermore,
plant-based
foods
marketed
with
a
low
carbon
footprint
represent
contribution
the
consumers
industry
cleaner
climate-change-free
Earth.
Production
processes
often
include
technologies
such
3D
printing,
extrusion
shear
cell
where
have
be
carefully
picked
because
their
influence
on
structural
textural
properties
final
product,
and,
in
consequence,
consumer
perception
acceptance
product.
This
review
paper
gives
an
extensive
overview
analogue
components,
which
affect
structure
discusses
complex
interaction
those
reflects
numerous
studies
been
performed
area,
but
also
emphasizes
need
future
research
optimization
mixture
used
production,
well
production
process.
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1149 - 1149
Published: March 26, 2025
Hemp
is
a
multiuse
crop
used
for
fiber,
food,
and
medicinal
purposes.
The
seed
of
hemp
has
attracted
great
attention
as
good
plant
protein
resource
with
remarkable
nutritional
biological
properties.
However,
the
application
(HSP)
limited
due
to
its
unsatisfactory
functional
Physical,
chemical,
technologies
have
been
explored
modify
structure
HSP
improve
functionality.
investigation
activity
derived
peptide
deal
intestinal,
metabolic,
muscle
concerns
broadened
utilization
in
healthy
products.
Therefore,
current
review
performed
summarize
recent
research
progress
on
novel
extraction
modification
HSP,
well
purification
identification
active
peptide.
multi-functional
multi-bioactive
properties
adverse
effects
are
also
depicted
facilitate
their
potential
applications
food
industry.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(1), P. e0287840 - e0287840
Published: Jan. 2, 2024
Tropical
almond
(
Terminalia
catappa
Linn.)
is
highly
distributed
within
the
tropics,
but
appears
rather
underutilized
in
developing
countries
like
Nigeria.
Specifically,
relevant
information
regards
nutritional,
health
benefits,
and
pharmaceutical
potential
of
roasted
T
.
nuts
remains
scanty.
Comparing
both
raw
should
provide
additional
especially
from
product
development
commercial
prospect
standpoints.
The
changes
potentials
were,
therefore,
investigated.
Whereas
obtained
significantly
(p
<
0.05)
higher
protein,
ash,
moisture,
crude
fiber,
as
well
vitamins
C,
B
1-3
compared
to
ones,
some
contents
carbohydrates,
energy,
vitamin
A,
calcium,
manganese,
zinc,
hydrogen
cyanide,
oxalate
would
noticeably
change
after
roasting
process.
Twenty
phytochemicals
were
identified
samples
with
concentrations
quinine,
ribalinidine,
sapogenin,
flavan-3-ol
tannin
reduced,
while
catechin
seemed
enhanced
upon
roasting.
Promising
drug-likeness,
pharmacokinetic
properties,
safety
profiles
could
be
predicted
among
phytochemicals.
Overall,
enhance
nutritional
contents,
which
aid
absorption
palatability.
Foods,
Journal Year:
2024,
Volume and Issue:
13(13), P. 2045 - 2045
Published: June 27, 2024
Sacha
inchi
(Plukenetia
volubilis
L.)
is
an
under-exploited
crop
with
great
potential
due
to
its
nutritional
and
medicinal
characteristics.
A
protein
isolate
(SII),
obtained
from
defatted
flour
(SIF),
was
hydrolyzed
by
Bioprotease
LA
660
under
specific
conditions.
The
hydrolysates
were
characterized
chemically,
their
digestibility
antioxidant
capacity
evaluated
in
vitro
cell-free
experiments
select
the
hydrolysate
major
activity.
at
20
min
(SIH20B)
selected,
anti-inflammatory
RT-qPCR
ELISA
techniques,
using
two
different
doses
monocytes
THP-1
stimulated
lipopolysaccharide
(LPS).
results
showed
that
administration
of
SIH20B
down-regulated
TNF-α
gene
reduced
release
this
cytokine,
whereas
cytokines
IL-10
IL-4
up-regulated
LPS-stimulated
co-administrated
SIH20B.
peptides
contained
identified,
more
relatively
abundant
a
mass
1
kDa
subjected
silico
analysis
hypothesize
those
could
be
responsible
for
bioactivity
reported
hydrolysate.
From
identified
peptides,
AAGALKKFL
LGVKFKGGL,
among
others,
are
proposed
as
most
biologically
actives.
In
conclusion,
novel,
natural
source
high-value-added
biopeptides
used
ingredient
formulations
food
or
nutraceutical
compounds.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(12), P. 2379 - 2379
Published: June 8, 2022
Nowadays,
notwithstanding
their
nutritional
and
technological
properties,
food
bioactive
peptides
from
plant
sources
garner
increasing
attention
for
ability
to
impart
more
than
one
beneficial
effect
on
human
health.
Legumes,
which
stand
out
thanks
high
protein
content,
represent
valuable
of
peptides.
In
this
context,
study
focused
the
characterization
potential
pleotropic
activity
two
commercially
available
soybean
(SH)
pea
(PH)
hydrolysates,
respectively.
Since
biological
a
specific
hydrolysate
is
strictly
correlated
with
its
chemical
composition,
first
aim
was
identify
compositions
SH
PH
Peptidomic
analysis
revealed
that
most
identified
within
both
mixtures
belong
storage
proteins.
Interestingly,
according
BIOPEP-UWM
database,
all
contain
active
motive
known
inhibitory
angiotensin
converting
enzyme
(ACE)
dipeptidyl-dipeptidases
(DPP)-IV
sequences.
Indeed,
results
indicated
inhibit
DPP-IV
ACE
dose-response
trend
IC50
values
equal
1.15
±
0.004
1.33
mg/mL,
0.33
0.01
0.61
0.05
addition,
hydrolysates
reduced
enzymes
are
expressed
surface
intestinal
Caco-2
cells.
These
findings
clearly
support
notion
may
new
ingredients
anti-diabetic
hypotensive
effects
development
innovative
multifunctional
foods
and/or
nutraceuticals
prevention
metabolic
syndrome.
Food Materials Research,
Journal Year:
2024,
Volume and Issue:
4(1), P. 0 - 0
Published: Jan. 1, 2024
This
article
introduces
the
concept
of
functional
foods
derived
from
underutilized
crops,
emphasizing
manifold
benefits
they
bring
to
farmers,
communities,
and
health.
Economically,
these
crops
present
a
valuable
opportunity
for
offering
increased
income
diversification
agricultural
practices.
Furthermore,
are
lauded
their
environmental
sustainability,
contributing
reduced
ecological
strain
promoting
biodiversity.
In
realm
health
nutrition,
crop
superfoods
have
pivotal
role
play.
They
known
disease
prevention
properties,
with
certain
possessing
anti-inflammatory
anticancer
attributes.
Additionally,
aid
in
improving
digestion,
relief
those
gastrointestinal
issues.
Their
high
levels
antioxidants
bolster
cellular
combat
free
radicals.
Enhanced
immune
function
is
another
notable
benefit,
providing
better
resilience
against
diseases.
Moreover,
weight
management
by
nutrient-rich,
calorie-efficient
alternative.
Specific
examples
including
amaranth,
black
rice,
quinoa,
more,
thoroughly
examined
nutritional
richness
culinary
versatility,
underlining
suitability
daily
dietary
incorporation.
The
also
delves
into
impact
microbiological
innovations
developing
foods,
shedding
light
on
technological
advancements
that
create
healthier,
more
accessible
food
products.
An
essential
aspect
this
exploration
consideration
policy
interventions
promote
crops.
paper
underscores
necessity
government
support
awareness
campaigns
harness
full
potential
advocates
broader
recognition
integration
everyday
diets
By
doing
so,
it
aspires
pave
way
sustainable,
empowered
future
where
"gastronomic
goldmines"
form
cornerstone
wellness
nutrition.