Hair Growth-Promoting Effect of Hydrangea serrata (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study DOI Open Access
Soyoon Park, Hyunjae Kim, Hye Shin Ahn

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10370 - 10370

Published: Sept. 26, 2024

With the escalating prevalence of hair loss, demand for effective loss treatment has surged. This study evaluated effects hot water extract Hydrangea serrata (Thunb.) Ser. leaf (WHS) on growth, employing cell cultures, mice, and human skin organoid models. Both WHS hydrangenol were found to enhance 5α-reductase inhibitory activity. have been shown stimulate dermal papilla (DPC) potentially through factors like keratinocyte growth factor (KGF), fibroblast 10 (FGF10), transforming factor-β1 (TGF-β1). They also elevated expression levels keratin genes (K31 K85) ceramide synthase (CerS3) gene, crucial clinical indicators health. Furthermore, they exhibited notable anti-inflammatory anti-androgenic properties by reducing tumor necrosis factor-α (TNF-α) androgen signaling molecules, including receptor (AR) dickkopf-1 (DKK-1) gene expression. Oral administration C57BL/6 mice 3 weeks confirmed its growth-promoting effects, improving parameters without significant changes in weight. Additionally, a model, was formation augment follicle markers. These findings position as promising nutraceutical promoting health, evidenced efficacy both vitro vivo

Language: Английский

Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features DOI Creative Commons
Annalisa Givonetti, Stelvio Tonello, Chiara Cattaneo

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 225 - 225

Published: Feb. 4, 2025

Hempseeds, from the Cannabis sativa plant, and its derivates are a versatile food option for various dietary preferences. Due to their aminoacidic profile, researchers have studied presence of bioactive peptides in hempseed proteins. In this study, water-soluble fraction protein was extracted, derived were analyzed. The investigation focused on biological function, particularly antioxidant activity. Several functions arisen, such as angiotensin-converting enzyme inhibition activity, dipeptidyl-peptidase IV, III inhibition, ubiquitin-mediated proteolysis activation. hydrolysates show greater 2,2-azinobis-[3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity compared proteins (97.95 ± 4.48 versus 81.04 10.63). Furthermore, impact these U937 cell line evaluated assess viability potential role modulating inflammation associated with gastrointestinal autoimmune diseases. Protein treatment resulted significant reduction viability, opposed hydrolysates, which did not affect it.

Language: Английский

Citations

1

An Overview of Ingredients Used for Plant-Based Meat Analogue Production and Their Influence on Structural and Textural Properties of the Final Product DOI Creative Commons
Maja Benković, Ana Jurinjak Tušek,

Tea Sokač Cvetnić

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 921 - 921

Published: Nov. 22, 2023

Plant-based meat analogues are food products made from vegetarian or vegan ingredients that intended to mimic taste, texture and appearance of meat. They becoming increasingly popular as people look for more sustainable healthy protein sources. Furthermore, plant-based foods marketed with a low carbon footprint represent contribution the consumers industry cleaner climate-change-free Earth. Production processes often include technologies such 3D printing, extrusion shear cell where have be carefully picked because their influence on structural textural properties final product, and, in consequence, consumer perception acceptance product. This review paper gives an extensive overview analogue components, which affect structure discusses complex interaction those reflects numerous studies been performed area, but also emphasizes need future research optimization mixture used production, well production process.

Language: Английский

Citations

15

Preparation, Modification, Food Application, and Health Effects of Protein and Peptide from Hemp (Cannabis sativa L.) Seed: A Review of the Recent Literature DOI Creative Commons
Xiaoqin Zhang, Wei Zhou, Xiaoli Qin

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1149 - 1149

Published: March 26, 2025

Hemp is a multiuse crop used for fiber, food, and medicinal purposes. The seed of hemp has attracted great attention as good plant protein resource with remarkable nutritional biological properties. However, the application (HSP) limited due to its unsatisfactory functional Physical, chemical, technologies have been explored modify structure HSP improve functionality. investigation activity derived peptide deal intestinal, metabolic, muscle concerns broadened utilization in healthy products. Therefore, current review performed summarize recent research progress on novel extraction modification HSP, well purification identification active peptide. multi-functional multi-bioactive properties adverse effects are also depicted facilitate their potential applications food industry.

Language: Английский

Citations

0

Isolation and functional characterization of hemp seed protein-derived short- and medium-chain peptide mixtures with multifunctional properties for metabolic syndrome prevention DOI
Andrea Cerrato, Carmen Lammi, Anna Laura Capriotti

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 163, P. 112219 - 112219

Published: Nov. 24, 2022

Language: Английский

Citations

16

Changes in nutritional, health benefits, and pharmaceutical potential of raw and roasted tropical almond (Terminalia catappa Linn.) nuts from Nigeria DOI Creative Commons
Ifeoma Felicia Chukwuma, Emmanuel Chekwube Ossai, Florence Nkechi Nworah

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0287840 - e0287840

Published: Jan. 2, 2024

Tropical almond ( Terminalia catappa Linn.) is highly distributed within the tropics, but appears rather underutilized in developing countries like Nigeria. Specifically, relevant information regards nutritional, health benefits, and pharmaceutical potential of roasted T . nuts remains scanty. Comparing both raw should provide additional especially from product development commercial prospect standpoints. The changes potentials were, therefore, investigated. Whereas obtained significantly (p < 0.05) higher protein, ash, moisture, crude fiber, as well vitamins C, B 1-3 compared to ones, some contents carbohydrates, energy, vitamin A, calcium, manganese, zinc, hydrogen cyanide, oxalate would noticeably change after roasting process. Twenty phytochemicals were identified samples with concentrations quinine, ribalinidine, sapogenin, flavan-3-ol tannin reduced, while catechin seemed enhanced upon roasting. Promising drug-likeness, pharmacokinetic properties, safety profiles could be predicted among phytochemicals. Overall, enhance nutritional contents, which aid absorption palatability.

Language: Английский

Citations

3

Sacha Inchi (Plukenetia volubilis L.) Protein Hydrolysate as a New Ingredient of Functional Foods DOI Creative Commons
Ana Lemus‐Conejo, Álvaro Villanueva, María E. Martín

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2045 - 2045

Published: June 27, 2024

Sacha inchi (Plukenetia volubilis L.) is an under-exploited crop with great potential due to its nutritional and medicinal characteristics. A protein isolate (SII), obtained from defatted flour (SIF), was hydrolyzed by Bioprotease LA 660 under specific conditions. The hydrolysates were characterized chemically, their digestibility antioxidant capacity evaluated in vitro cell-free experiments select the hydrolysate major activity. at 20 min (SIH20B) selected, anti-inflammatory RT-qPCR ELISA techniques, using two different doses monocytes THP-1 stimulated lipopolysaccharide (LPS). results showed that administration of SIH20B down-regulated TNF-α gene reduced release this cytokine, whereas cytokines IL-10 IL-4 up-regulated LPS-stimulated co-administrated SIH20B. peptides contained identified, more relatively abundant a mass 1 kDa subjected silico analysis hypothesize those could be responsible for bioactivity reported hydrolysate. From identified peptides, AAGALKKFL LGVKFKGGL, among others, are proposed as most biologically actives. In conclusion, novel, natural source high-value-added biopeptides used ingredient formulations food or nutraceutical compounds.

Language: Английский

Citations

3

Integrated Evaluation of the Multifunctional DPP-IV and ACE Inhibitory Effect of Soybean and Pea Protein Hydrolysates DOI Open Access
Carlotta Bollati,

Ruoxian Xu,

Giovanna Boschin

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2379 - 2379

Published: June 8, 2022

Nowadays, notwithstanding their nutritional and technological properties, food bioactive peptides from plant sources garner increasing attention for ability to impart more than one beneficial effect on human health. Legumes, which stand out thanks high protein content, represent valuable of peptides. In this context, study focused the characterization potential pleotropic activity two commercially available soybean (SH) pea (PH) hydrolysates, respectively. Since biological a specific hydrolysate is strictly correlated with its chemical composition, first aim was identify compositions SH PH Peptidomic analysis revealed that most identified within both mixtures belong storage proteins. Interestingly, according BIOPEP-UWM database, all contain active motive known inhibitory angiotensin converting enzyme (ACE) dipeptidyl-dipeptidases (DPP)-IV sequences. Indeed, results indicated inhibit DPP-IV ACE dose-response trend IC50 values equal 1.15 ± 0.004 1.33 mg/mL, 0.33 0.01 0.61 0.05 addition, hydrolysates reduced enzymes are expressed surface intestinal Caco-2 cells. These findings clearly support notion may new ingredients anti-diabetic hypotensive effects development innovative multifunctional foods and/or nutraceuticals prevention metabolic syndrome.

Language: Английский

Citations

13

Hempseed protein-derived short- and medium-chain peptides and their multifunctional properties DOI

Sara Elsa Aita,

Carmela Maria Montone, Enrico Taglioni

et al.

Advances in food and nutrition research, Journal Year: 2024, Volume and Issue: unknown, P. 275 - 325

Published: Jan. 1, 2024

Language: Английский

Citations

2

Nourishing discoveries: Harnessing wellness with lesser known superfoods DOI Creative Commons
Anurag Yadav, Kusum Yadav

Food Materials Research, Journal Year: 2024, Volume and Issue: 4(1), P. 0 - 0

Published: Jan. 1, 2024

This article introduces the concept of functional foods derived from underutilized crops, emphasizing manifold benefits they bring to farmers, communities, and health. Economically, these crops present a valuable opportunity for offering increased income diversification agricultural practices. Furthermore, are lauded their environmental sustainability, contributing reduced ecological strain promoting biodiversity. In realm health nutrition, crop superfoods have pivotal role play. They known disease prevention properties, with certain possessing anti-inflammatory anticancer attributes. </sec><sec><title/> Additionally, aid in improving digestion, relief those gastrointestinal issues. Their high levels antioxidants bolster cellular combat free radicals. Enhanced immune function is another notable benefit, providing better resilience against diseases. Moreover, weight management by nutrient-rich, calorie-efficient alternative. Specific examples including amaranth, black rice, quinoa, more, thoroughly examined nutritional richness culinary versatility, underlining suitability daily dietary incorporation. The also delves into impact microbiological innovations developing foods, shedding light on technological advancements that create healthier, more accessible food products. An essential aspect this exploration consideration policy interventions promote crops. paper underscores necessity government support awareness campaigns harness full potential advocates broader recognition integration everyday diets By doing so, it aspires pave way sustainable, empowered future where "gastronomic goldmines" form cornerstone wellness nutrition. </sec> </p> <!--End Abstract--> <p class="papers_lang"> <span class="fw-bold">Language:</span> Английский </p> <div class="paper_static"> <div class="count"> <p class="count_p">Citations</p> <a href="/en/articles/doi/https:++doi.org+10.48130+fmr-0024-0002">1</a> </div> </div> <hr> <span class="papers_title"> <a href="https://doi.org/10.1016/b978-0-443-15437-9.00013-6" > Proteolytic enzymes for production of functional protein hydrolysates and bioactive peptides </a> <img title="DOI" src="/static/images/article/DOI_logo.svg" alt="DOI" style="width:25px; height:25px"> </span> <!--Author list section--> <div class="list-authors"> <a class="popover5058945148 papers_author" data-bs-toggle="popover" tabindex="0" data-bs-trigger="hover focus" data-bs-placement="top" href="https://orcid.org/0000-0002-1425-4250">Miguel A. Mazorra‐Manzano,</a> <div hidden> <div id="popover-content5058945148"> <p> No information about this author </p> </div> </div> <a class="popover5053685251 papers_author" data-bs-toggle="popover" tabindex="0" data-bs-trigger="hover focus" data-bs-placement="top" href="https://orcid.org/0000-0001-8512-1271">Juan Carlos Ramírez‐Suárez</a> <div hidden> <div id="popover-content5053685251"> <p> No information about this author </p> </div> </div> </div> <!--End Author list section--> <!--Start journal--> <p> <span class="papers_journal">Elsevier eBooks,</span> <span style="font-size: 0.8rem;"> Journal Year: 2024, Volume and Issue: unknown, P. 325 - 354 </span></p> <!--End journal--> <p class="papers_pub"><span class="fw-bold">Published:</span> Jan. 1, 2024</p> <p class="papers_lang"> <span class="fw-bold">Language:</span> Английский </p> <div class="paper_static"> <div class="count"> <p class="count_p">Citations</p> <a 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