Maackiain: A Comprehensive Review of its Pharmacology, Synthesis, Pharmacokinetics and Toxicity DOI

Waqas Haider,

Wei Pan, Dayang Wang

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 405, P. 111294 - 111294

Published: Oct. 30, 2024

Language: Английский

The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli DOI Creative Commons

Jinwu Meng,

Weiran Wang,

Jinxue Ding

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(10), P. 104151 - 104151

Published: July 31, 2024

Infection by multidrug-resistant avian pathogenic Escherichia coli (APEC) in chickens always leads to the uselessness of antibiotics, highlighting need for alternative antibacterial agents. Sophora flavescens and Coptis chinensis have been a classical combination used together Traditional Chinese Medicine (TCM) formulas treat diseases with similar symptoms colibacillosis an extended period, but effect their active ingredients' on APEC infection remains unstudied. The objective this study was explore synergistic matrine berberine hydrochloride caused isolated APEC. In study, highly E. from liver diseased chicken farm suspected colibacillosis, it resistant multiple antibiotics. LD

Language: Английский

Citations

8

Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis DOI

Weichen Liu,

Xue Tian, Lingwen Gu

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 240, P. 109830 - 109830

Published: Feb. 15, 2024

Language: Английский

Citations

2

Oxymatrine Modulation of TLR3 Signaling Pathway: A Dual-Action Mechanism against H9N2 Avian Influenza Virus and Immune Regulation DOI Creative Commons

Yan Zhi,

Zhenyi Liu,

Guo Shen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 18, 2024

Abstract Background H9N2 Avian Influenza Virus (AIV) poses a growing public health threat due to its rapid mutation rate and limited vaccine efficacy. Pulmonary Microvascular Endothelial Cells (PMVECs) play critical role as gateway for infection, highlighting the need alternative therapeutic strategies. This study examines antiviral potential of Oxymatrine (OMT), traditional Chinese medicine derivative, against AIV in PMVECs. Purpose The aim this is explore efficacy OMT modulating responses elucidate impact on TLR3 signaling pathway PMVECs infected with AIV. Study Design Methods: Using an array vitro assays such TCID50, CCK-8, RT-qPCR, ELISA, Western blot, evaluated viral infectivity, cell viability, gene protein expression levels, key cytokine levels Additionally, RNAi technology was employed silence genes further understand mechanisms involved. Results displayed dose-dependent inhibitory effect vital proteins PKR Mx1 modulated Type I interferons cytokines including IFN-α, IFN-β, IL-6, TNF-α. It significantly impacted pathways, affecting downstream components NF-κB IRF-3. silencing studies indicated that OMT's not solely dependent pathway. Conclusion Our findings reveal exhibits dual-action mechanism by inhibiting immune PMVECs, primarily through These results lay promising foundation development

Language: Английский

Citations

1

Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation DOI Creative Commons
Yan Zhi,

Xin-Ping Zhao,

Zhenyi Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1945 - 1945

Published: April 24, 2024

In our research, we explored a natural substance called Oxymatrine, found in traditional Chinese medicinal plant, to fight against common bird flu virus known as H9N2. This not only affects birds but can also pose threat human health. We focused on how this compound help stopping the from spreading cells that line lungs of and potentially humans. Our findings show Oxymatrine both directly block boost body’s immune response it. dual-action mechanism is particularly interesting because it indicates might be useful tool developing new ways prevent treat type flu. Understanding works H9N2 could lead safer more combat viral infections animals humans, contributing health well-being society. The Avian Influenza Virus (AIV) persistent its rapid mutation rate limited efficacy vaccines, underscoring urgent need for innovative therapies. study investigated AIV antiviral properties (OMT), derived medicine, focusing interaction with pulmonary microvascular endothelial (PMVECs). Employing an array vitro assays, including 50% tissue culture infectious dose, Cell Counting Kit-8, reverse transcription-quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, Western blot, systematically elucidated multifaceted effects OMT. OMT dose-dependently inhibited critical proteins (PKR Mx1) modulated expression I interferons key cytokines (IFN-α, IFN-β, IL-6, TNF-α), thereby affecting TLR3 signaling downstream elements (NF-κB IRF-3). OMT’s extended beyond TLR3-mediated responses, suggesting potential versatile agent. contributes growing body research use compounds agents underscores importance further investigating broader application combating infections.

Language: Английский

Citations

1

Dietary supplementation of patchouli oil improves resistance to Streptococcus agalactiae infection in genetically improved cultured Tilapia (GIFT, Oreochromis niloticus.) as revealed by RNA-Seq DOI

Yin Yi Yao,

Zong Xian Zhu,

Chun Hui Ai

et al.

Aquaculture, Journal Year: 2023, Volume and Issue: 578, P. 740147 - 740147

Published: Sept. 22, 2023

Language: Английский

Citations

1

Oxymatrine Modulation of TLR3 Signaling Pathway: A Dual-Action Mechanism Against H9N2 Avian Influenza Virus and Immune Regulation DOI

Yan Zhi,

Zhenyi Liu,

Guoyu Shen

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0

EVALUATION OF WALNUT GREEN HUSK, CAPPARIS SPINOSA, CISTANCHES HERBA, ECLIPTA PROSTRATA, SCUTELLARIA BARBATA, SARGENTODOXA CUNEATA, AND SOPHORA FLAVESCENS EXTRACTS AGAINST STAPHYLOCOCCUS AUREUS, ESCHERICHIA COLI, AND SALMONELLA ENTERITIDIS DOI Creative Commons

Bing-Long Chen,

M F Qiu,

Mengjian Liu

et al.

The Journal of Animal and Plant Sciences, Journal Year: 2024, Volume and Issue: 5, P. 1153 - 1165

Published: Aug. 22, 2024

Herbs are widely used in the treatment of a wide range illnesses humans and animals. They contain an array natural antibacterial compounds possess potent properties, making them promising source low-toxicity, high-efficiency alternative antimicrobial agents that less likely to develop drug resistance. In this experiment, total phenols flavonoids, free radical scavenging ability extracts derived from seven traditional Chinese herbs, including walnut (Juglans regia) green husk, Cistanche herba, Capparis spinosa, Eclipta prostrata, Sophora flavescens, Scutellaria barbata, Sargentodoxa cuneata, were investigated. Furthermore, properties against Staphylococcus aureus, Escherichia coli, Salmonella enteritidis assessed. The results showed concentrations flavonoids ranged 5.45 226.89 mg gallic acid equivalent (GAE)/mL 7.34 428.04 rutin (RE)/mL, respectively. S. cuneata extract exhibited highest contents which significantly higher than those other herbs (P < 0.05). 2,2-diphenyl-1-picrylhydrazyl (DPPH) rates 28.25% 85.33%. E. prostrata antioxidant activity as compared Extract husk possessed best aureus with inhibition zone diameters 13.05 8.59 mm, respectively, greater herbal For barbata displayed diameter 9.83 mm. Based on findings current study, it is concluded favorable capacity have potential serve alternatives for antibiotics. Keywords: Herbs, phenols, activity,

Language: Английский

Citations

0

Maackiain: A Comprehensive Review of its Pharmacology, Synthesis, Pharmacokinetics and Toxicity DOI

Waqas Haider,

Wei Pan, Dayang Wang

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 405, P. 111294 - 111294

Published: Oct. 30, 2024

Language: Английский

Citations

0