Pathogenomic Insights into Piscirickettsia salmonis with a Focus on Virulence Factors, Single-Nucleotide Polymorphism Identification, and Resistance Dynamics DOI Creative Commons
Sk Injamamul Islam,

Khandker Shahed,

Md Shakil Ahamed

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(8), P. 1176 - 1176

Published: April 20, 2025

Effective control of bacterial infections remains a significant challenge in aquaculture. The marine bacterium Piscirickettsia salmonis (P. salmonis), responsible for piscirickettsiosis, causes widespread various salmon species, leading to substantial mortality and economic losses. Despite efforts genetically characterize P. salmonis, critical gaps persist understanding its virulence factors, antimicrobial resistance genes, single-nucleotide polymorphisms (SNPs). This study addresses these through comparative analysis the pan-genome core genomes 80 strains from different geographical regions genogroups. had an open consisting 14,564 with genome 1257 conserved genes. Eleven virulence-related genes were identified pan-genome, categorized into five functional groups, providing new insights pathogenicity salmonis. Unique SNPs detected four key (gyrA, dnaK, rpoB, ftsZ), serving as robust molecular markers distinguishing LF EM Notably, AMR suggest evolutionary adaptations under selective pressure. Functional annotation using gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases demonstrated clusters linked essential intracellular survival mechanisms pathogenicity. These findings direct association between features variations pathogenesis host–pathogen interactions across Phylogenetic reconstruction further highlighted influence on strain divergence. Collectively, this enhances genomic lays groundwork improved diagnostic tools targeted therapeutics manage piscirickettsiosis

Language: Английский

Pathogenomic Insights into Piscirickettsia salmonis with a Focus on Virulence Factors, Single-Nucleotide Polymorphism Identification, and Resistance Dynamics DOI Creative Commons
Sk Injamamul Islam,

Khandker Shahed,

Md Shakil Ahamed

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(8), P. 1176 - 1176

Published: April 20, 2025

Effective control of bacterial infections remains a significant challenge in aquaculture. The marine bacterium Piscirickettsia salmonis (P. salmonis), responsible for piscirickettsiosis, causes widespread various salmon species, leading to substantial mortality and economic losses. Despite efforts genetically characterize P. salmonis, critical gaps persist understanding its virulence factors, antimicrobial resistance genes, single-nucleotide polymorphisms (SNPs). This study addresses these through comparative analysis the pan-genome core genomes 80 strains from different geographical regions genogroups. had an open consisting 14,564 with genome 1257 conserved genes. Eleven virulence-related genes were identified pan-genome, categorized into five functional groups, providing new insights pathogenicity salmonis. Unique SNPs detected four key (gyrA, dnaK, rpoB, ftsZ), serving as robust molecular markers distinguishing LF EM Notably, AMR suggest evolutionary adaptations under selective pressure. Functional annotation using gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases demonstrated clusters linked essential intracellular survival mechanisms pathogenicity. These findings direct association between features variations pathogenesis host–pathogen interactions across Phylogenetic reconstruction further highlighted influence on strain divergence. Collectively, this enhances genomic lays groundwork improved diagnostic tools targeted therapeutics manage piscirickettsiosis

Language: Английский

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