Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed association of with percentage time that ambulatory blood pressure (ABP) within target range (PTTR) proposed by 2024 European Society Cardiology (ESC) guidelines for (BP) management. In a person-level meta-analysis 14 230 individuals enrolled in population cohorts, systolic and diastolic ABPs were combined to assess 24-h, daytime, nighttime PTTR thresholds non-elevated ABP set at <115/65, <120/70, <110/60 mmHg, respectively. Median 24-h was 18% (interquartile 5-33) corresponding 4.3 h (1.2-7.9). Over 10.9 years (median), deaths (N = 3117) endpoints 2265) decreased across increasing quartiles from 21.3 16.1 20.3 11.3 events per 1000 person-years. The standardized multivariable-adjusted hazard ratios 0.57 (95% confidence interval 0.46-0.71) mortality 0.30 (0.23-0.39) endpoints. Analyses daytime ABP, mortality, coronary stroke, subgroups produced confirmatory results. ESC PTTR, compared 2018 ESC/European non-hypertensive shortened required reduce relative adverse outcomes 60% (14.4-4.3 h). Office BP, misclassified most participants regard BP control. Longer associated reduced outcomes; derived refines prediction office avoids misclassification

Language: Английский

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Optimal Blood Pressure Targets with Age

Clinics in Geriatric Medicine, Journal Year: 2024, Volume and Issue: 40(4), P. 585 - 595

Published: May 10, 2024

Language: Английский

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