Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals DOI Creative Commons
Zimu Wu, Lachlan Cribb, Rory Wolfe

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2458591 - e2458591

Published: Feb. 7, 2025

Importance Poor cardiometabolic health is a risk factor associated with cognitive impairment in later life, but it remains unclear whether trajectories can serve as early markers dementia. Objective To compare that precede dementia diagnosis those among individuals without Design, Setting, and Participants This case-control study analyzed sample drawn from community-dwelling participants the Aspirin Reducing Events Elderly (ASPREE) study. Recruitment through primary care physicians occurred between March 2010 December 2014, followed up for maximum of 11 years. Dementia cases were matched on sociodemographic characteristics time to dementia-free controls. Data analysis was performed February June 2024. Exposures Body mass index (BMI), waist circumference, systolic diastolic blood pressure, glucose levels, high- low-density lipoprotein (HDL LDL) total cholesterol triglyceride levels measured repeatedly 2022. Main Outcomes Measures ( Diagnostic Statistical Manual Mental Disorders [ Fourth Edition ] criteria) adjudicated by an international expert panel. Results Among 5390 (mean [SD] age, 76.9 [4.8] years; 2915 women [54.1%]), there 2655 (49.3%) less than 12 years education. The included 1078 4312 Up decade before diagnosis, compared controls had lower BMI all −7 (marginal estimate, 27.52 [95% CI, 27.24 27.79] vs 28.00 27.86 28.14]; contrast P = 002) 0 26.09 25.81 26.36] 27.22 27.09 27.36]; < .001) circumference −10 95.45 cm 94.33 96.57 cm] 97.35 96.79 97.92 cm]; .003) 93.90 93.15 94.64 96.67 96.30 97.05 .001); also faster decline (linear change β, −0.13 −0.19 −0.08]) −0.30 −0.51 −0.08 cm]). Compared controls, generally higher HDL particular 5 62.57 mg/dL 61.59 63.56 mg/dL] 60.84 60.35 61.34 mg/dL]; .002) 3 62.78 61.82 63.74 61.08 60.60 61.56 just −0.47 −0.86 −0.07 mg/dL]). pressure LDL these not significantly different Conclusions Relevance In this older individuals, BMI, diagnosis. These findings provide insights into changes preceding potential monitoring intervention.

Language: Английский

Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals DOI Creative Commons
Zimu Wu, Lachlan Cribb, Rory Wolfe

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2458591 - e2458591

Published: Feb. 7, 2025

Importance Poor cardiometabolic health is a risk factor associated with cognitive impairment in later life, but it remains unclear whether trajectories can serve as early markers dementia. Objective To compare that precede dementia diagnosis those among individuals without Design, Setting, and Participants This case-control study analyzed sample drawn from community-dwelling participants the Aspirin Reducing Events Elderly (ASPREE) study. Recruitment through primary care physicians occurred between March 2010 December 2014, followed up for maximum of 11 years. Dementia cases were matched on sociodemographic characteristics time to dementia-free controls. Data analysis was performed February June 2024. Exposures Body mass index (BMI), waist circumference, systolic diastolic blood pressure, glucose levels, high- low-density lipoprotein (HDL LDL) total cholesterol triglyceride levels measured repeatedly 2022. Main Outcomes Measures ( Diagnostic Statistical Manual Mental Disorders [ Fourth Edition ] criteria) adjudicated by an international expert panel. Results Among 5390 (mean [SD] age, 76.9 [4.8] years; 2915 women [54.1%]), there 2655 (49.3%) less than 12 years education. The included 1078 4312 Up decade before diagnosis, compared controls had lower BMI all −7 (marginal estimate, 27.52 [95% CI, 27.24 27.79] vs 28.00 27.86 28.14]; contrast P = 002) 0 26.09 25.81 26.36] 27.22 27.09 27.36]; < .001) circumference −10 95.45 cm 94.33 96.57 cm] 97.35 96.79 97.92 cm]; .003) 93.90 93.15 94.64 96.67 96.30 97.05 .001); also faster decline (linear change β, −0.13 −0.19 −0.08]) −0.30 −0.51 −0.08 cm]). Compared controls, generally higher HDL particular 5 62.57 mg/dL 61.59 63.56 mg/dL] 60.84 60.35 61.34 mg/dL]; .002) 3 62.78 61.82 63.74 61.08 60.60 61.56 just −0.47 −0.86 −0.07 mg/dL]). pressure LDL these not significantly different Conclusions Relevance In this older individuals, BMI, diagnosis. These findings provide insights into changes preceding potential monitoring intervention.

Language: Английский

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