Associations between sex, race/ethnicity, and age and the initiation of chronic high‐risk medication in US older adults DOI Creative Commons
Katharina Tabea Jungo, Niteesh K. Choudhry, Alexander Chaitoff

et al.

Journal of the American Geriatrics Society, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Abstract Background High‐risk medication use is associated with an increased risk of adverse events, but little known about its chronic utilization by key demographic groups. We aimed to study the associations between age, sex, and race/ethnicity new high‐risk medications in older adults. Methods In this retrospective cohort study, we analyzed data from adults aged ≥65 years enrolled a national health insurer who started 2017 2022 across 16 classes. used generalized estimating equations estimate sociodemographic classifications onset after initiation (≥90 days' supply ≥2 fills within 180 days). adjusted analyses for clinical patient characteristics added three‐way interaction terms race/ethnicity, age explore whether outcome varied different subgroups sex. Results Across 2,751,069 patients (mean age: 74 [SD = 7], 72% White, 60% Female), 406,075 (15%) became users ≥1 medication. Compared White adults, Asian (RR 0.81, 95% CI: 0.79–0.84), Black 0.92, 0.90–0.94), Hispanic 0.85, 0.83–0.86) had lower becoming users. Men higher compared women 1.09, 1.08–1.10). Age was not significantly (≥75 years: RR 1.00, 1.00–1.01). observed differences some classes, like benzodiazepines, first‐generation antihistamines, antimuscarinics which non‐White were at risk. The joint presence specific decreased user (e.g., Hispanic/Female/65–74 0.96, 0.94–0.99). Conclusions New characteristics, suggesting need individualize optimization approaches better understand how systematic barriers access care may influence

Language: Английский

Associations between sex, race/ethnicity, and age and the initiation of chronic high‐risk medication in US older adults DOI Creative Commons
Katharina Tabea Jungo, Niteesh K. Choudhry, Alexander Chaitoff

et al.

Journal of the American Geriatrics Society, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Abstract Background High‐risk medication use is associated with an increased risk of adverse events, but little known about its chronic utilization by key demographic groups. We aimed to study the associations between age, sex, and race/ethnicity new high‐risk medications in older adults. Methods In this retrospective cohort study, we analyzed data from adults aged ≥65 years enrolled a national health insurer who started 2017 2022 across 16 classes. used generalized estimating equations estimate sociodemographic classifications onset after initiation (≥90 days' supply ≥2 fills within 180 days). adjusted analyses for clinical patient characteristics added three‐way interaction terms race/ethnicity, age explore whether outcome varied different subgroups sex. Results Across 2,751,069 patients (mean age: 74 [SD = 7], 72% White, 60% Female), 406,075 (15%) became users ≥1 medication. Compared White adults, Asian (RR 0.81, 95% CI: 0.79–0.84), Black 0.92, 0.90–0.94), Hispanic 0.85, 0.83–0.86) had lower becoming users. Men higher compared women 1.09, 1.08–1.10). Age was not significantly (≥75 years: RR 1.00, 1.00–1.01). observed differences some classes, like benzodiazepines, first‐generation antihistamines, antimuscarinics which non‐White were at risk. The joint presence specific decreased user (e.g., Hispanic/Female/65–74 0.96, 0.94–0.99). Conclusions New characteristics, suggesting need individualize optimization approaches better understand how systematic barriers access care may influence

Language: Английский

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