Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 27, 2024
Motoric cognitive risk (MCR) syndrome is characterized by slow gait speed and subjective complaints (SCC) increases the of dementia mortality.
Language: Английский
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
The motoric cognitive risk syndrome (MCR) is a novel and clinically relevant pre-dementia indicating higher dementia (e.g., for Alzheimer's disease). Given that MCR prevalence unknown in Germany, we conducted cross-sectional study, which 208 participants from Germany aged 50 82 years answered an online survey including questions to assess subjective (sMCR). adjusted sMCR was 25.3%. Adults with reported more diseases showed negative associations physical activity, sedentary behavior, sleep, suggesting lifestyle modifications can play significant role prevention. Further research required complement our preliminary findings on Germany.
Language: Английский
Citations
0
Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 11, 2025
Abstract Background Motoric cognitive risk syndrome (MCR) has been associated with dementia, functional dependence, and mortality. We sought to describe the prevalence distribution of MCR explore clinical, biological, neuroimaging profiles for in rural‐dwelling Chinese older adults. Methods This population‐based study included 5021 dementia‐ disability‐free participants (mean age 70.3 years) MIND‐China. Of these, data were available 1186 blood biomarkers Alzheimer's disease vascular injury 1159 structural brain magnetic resonance imaging biomarkers. was defined as having both subjective memory complaints gait speed ≥1 standard deviation below age‐ sex‐specific means. Data analyzed using logistic regression models voxel‐based morphometry methods. Results The overall 13.58%, which higher females than males increased age. Controlling demographic lifestyle factors, obesity, diabetes, dyslipidemia, coronary heart disease, stroke, osteoarthritis, hip fracture, depressive symptoms significantly an elevated likelihood ( p < 0.05). smaller volumes total tissue, thalamus, hippocampus, cerebellum, insula, supplementary motor area, inferior frontal gyrus, white matter hyperintensities, lacunes (all 0.05), but not any examined > Conclusions affects approximately one‐seventh clinical are characterized by cardiometabolic disorders, well global regional atrophy cerebral microvascular lesions.
Language: Английский
Citations
0
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 4, 2025
We examined the association between neuropsychiatric symptoms (NPS) and motoric cognitive risk syndrome (MCR), a predementia condition indicating higher for dementia. A sample of 2800 older adults (≥ 65 years) was analyzed using binomial logistic regression to investigate cross-sectional relationship specific NPS MCR. Additionally, longitudinal analysis involving 1352 explored whether baseline predicted incident MCR risk. Subjects with exhibited prevalence NPS. The most common in were affective symptoms: apathy (71.5%), anxiety (55.4%), depression (45.7%). hallucinations (OR = 1.76, 95% CI 1.23-2.51), sleep impairment 1.40, 1.14-1.73), 3.31, 2.67-4.10), delusions 1.88, 1.25-2.84), irritability 1.98, 1.56-2.53), 1.71, 1.49-1.98), 1.92, 1.62-2.28). Longitudinally, 1.68, 1.17-2.42), 1.70, 1.31-2.21), 1.23-2.31) significantly (p < 0.005). Findings suggest that apathy, depression, are predictive MCR, underscoring importance screening identifying individuals at Early detection could facilitate development interventions prevent
Language: Английский
Citations
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Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Aug. 7, 2024
The association between lung function and motoric cognitive risk syndrome (MCR) is unclear. We aimed to explore the of peak expiratory flow (PEF) with MCR using cross-sectional longitudinal analyses.
Language: Английский
Citations
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Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 27, 2024
Motoric cognitive risk (MCR) syndrome is characterized by slow gait speed and subjective complaints (SCC) increases the of dementia mortality.
Language: Английский
Citations
0