Pharmacy-led interventions to reverse and prevent prescribing cascades in primary care: a proof-of-concept study DOI Creative Commons
Atiya K. Mohammad, Jacqueline G. Hugtenburg,

Yildiz Ceylan

et al.

International Journal of Clinical Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Prescribing cascades occur in clinical practice when a medication causes an adverse drug reaction (ADR), which is addressed by prescribing additional medication. The aim was to provide proof-of-concept for pharmacy-led interventions reverse or prevent cascades. Two community pharmacies each tested two approaches. To cascades, ten were selected from literature. Dispensing records screened identify patients with these who started medications associated five of telephoned one month after their first dispensing discuss ADRs. Pharmacists assessed the need intervene together prescribers. Primary outcome proportion treatment change initiated. Secondary outcomes time investment, potential cost-savings, and pharmacists' experiences. 24 included. For eight prescriber consulted, resulting reversal three Forty-four included Six them experienced ADR that could lead cascade. conducted this. estimated investment possibly intervention 4.5 h reversing approach 4.8 preventing approach, while follow-up actions required 1.8 0.5 h, respectively. Both approaches be cost-saving. considered both relevant but identified knowledge gap on how some Pharmacy-led may more efficient screening methods tools are needed before further implementation.

Language: Английский

Pharmacy-led interventions to reverse and prevent prescribing cascades in primary care: a proof-of-concept study DOI Creative Commons
Atiya K. Mohammad, Jacqueline G. Hugtenburg,

Yildiz Ceylan

et al.

International Journal of Clinical Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Prescribing cascades occur in clinical practice when a medication causes an adverse drug reaction (ADR), which is addressed by prescribing additional medication. The aim was to provide proof-of-concept for pharmacy-led interventions reverse or prevent cascades. Two community pharmacies each tested two approaches. To cascades, ten were selected from literature. Dispensing records screened identify patients with these who started medications associated five of telephoned one month after their first dispensing discuss ADRs. Pharmacists assessed the need intervene together prescribers. Primary outcome proportion treatment change initiated. Secondary outcomes time investment, potential cost-savings, and pharmacists' experiences. 24 included. For eight prescriber consulted, resulting reversal three Forty-four included Six them experienced ADR that could lead cascade. conducted this. estimated investment possibly intervention 4.5 h reversing approach 4.8 preventing approach, while follow-up actions required 1.8 0.5 h, respectively. Both approaches be cost-saving. considered both relevant but identified knowledge gap on how some Pharmacy-led may more efficient screening methods tools are needed before further implementation.

Language: Английский

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