Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy DOI Creative Commons
Xiaohong Zhao,

Qinyi Li,

Xiaolong Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Ischemia-reperfusion injury refers to the damage that occurs when blood supply is restored organs or tissues after a period of ischemia. This phenomenon commonly observed in clinical contexts such as organ transplantation and cardiac arrest resuscitation. Among these, hepatic ischemia-reperfusion prevalent complication liver transplantation, significantly impacting functional recovery transplanted potentially leading primary graft dysfunction. With growing demand for transplants limited availability donor organs, effectively addressing essential enhancing success rates, minimizing complications, improving survival. The pathogenesis multifaceted, involving factors oxidative stress inflammatory responses. article focuses on role protein post-translational modifications injury, including phosphorylation, ubiquitination, acetylation, ADP-ribosylation, SUMOylation, crotonylation, palmitoylation, S-nitrosylation. Initially, we examined historical discovery these subsequently investigated their impact cellular signal transduction, enzymatic activity, stability, protein-protein interactions. emphasis this study pivotal progression potential therapeutic targets. aims conduct comprehensive analysis recent advancements research investigate underlying molecular mechanisms, explore future trajectories. Additionally, directions are proposed, exploration interactions between various modifications, identification specific modification sites, development drugs targeting modifications. These efforts aim deepen our understanding pave way innovative interventions.

Language: Английский

Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy DOI Creative Commons
Xiaohong Zhao,

Qinyi Li,

Xiaolong Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Ischemia-reperfusion injury refers to the damage that occurs when blood supply is restored organs or tissues after a period of ischemia. This phenomenon commonly observed in clinical contexts such as organ transplantation and cardiac arrest resuscitation. Among these, hepatic ischemia-reperfusion prevalent complication liver transplantation, significantly impacting functional recovery transplanted potentially leading primary graft dysfunction. With growing demand for transplants limited availability donor organs, effectively addressing essential enhancing success rates, minimizing complications, improving survival. The pathogenesis multifaceted, involving factors oxidative stress inflammatory responses. article focuses on role protein post-translational modifications injury, including phosphorylation, ubiquitination, acetylation, ADP-ribosylation, SUMOylation, crotonylation, palmitoylation, S-nitrosylation. Initially, we examined historical discovery these subsequently investigated their impact cellular signal transduction, enzymatic activity, stability, protein-protein interactions. emphasis this study pivotal progression potential therapeutic targets. aims conduct comprehensive analysis recent advancements research investigate underlying molecular mechanisms, explore future trajectories. Additionally, directions are proposed, exploration interactions between various modifications, identification specific modification sites, development drugs targeting modifications. These efforts aim deepen our understanding pave way innovative interventions.

Language: Английский

Citations

0