Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 212, P. 102252 - 102252

Published: Feb. 25, 2022

Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity exploratory behavior, which occur in the absence clear goal or reward. This despite behavioral scientists having long suggested that behaviors regulated an innate drive. We refer such as information-seeking propose 1) key 2) concept environment prediction error a framework understand processes. The cognitive aspect including perception salience uncertainty, involves, part, pathways from posterior hypothalamic supramammillary region hippocampal formation. vigor modulated following: glutamatergic neurons; their projections medial septal neurons ventral tegmental dopaminergic Phasic responses characterized signaling potentially important stimuli rather than rewards. paper describes how novel uncertainty trigger seeking motivation these modulate behavior.

Language: Английский

---

Opioid withdrawal: role in addiction and neural mechanisms

Psychopharmacology, Journal Year: 2023, Volume and Issue: 240(7), P. 1417 - 1433

Published: May 10, 2023

Language: Английский

---

Regulation of sex differences in risk-based decision making by gonadal hormones: Insights from rodent models

Behavioural Processes, Journal Year: 2022, Volume and Issue: 200, P. 104663 - 104663

Published: June 2, 2022

Language: Английский

---

A nociceptive amygdala-striatal pathway for chronic pain aversion

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of

Language: Английский

---

Current Advances in Behavioral Addictions: From Fundamental Research to Clinical Practice

American Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 182(2), P. 155 - 163

Published: Dec. 11, 2024

Gambling disorder is the only behavioral addiction recognized as a clinical in DSM-5, and Internet gaming included condition requiring further research. ICD-11 categorizes gambling disorders due to addictive behaviors. Additional addictions may include compulsive sexual behavior disorder, buying-shopping problematic use of social media. This narrative review summarizes current state knowledge regarding these five (potential) All are clinically relevant prevalent. Behavioral frequently co-occur with other mental problems, such depression, anxiety, attention deficit hyperactivity disorder. Validated diagnostic instruments exist, empirical support varying across conditions. No medications have approved indications from regulatory bodies for addictions, cognitive-behavioral therapy has most efficacious treatment. Given that prevalent, psychiatric disorders, often go undiagnosed untreated, been linked poorer treatment outcomes, active screening indicated. Public health considerations should be expanded, impacts modern technologies investigated more intensively. Treatment optimization involving pharmacotherapy, psychotherapy, neuromodulation, their combination warrants additional investigation.

Language: Английский

---

Neuroanatomy Reflects Individual Variability in Impulsivity in Youth

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

A bstract Individual differences in neural circuits underlying emotional regulation, motivation, and decision-making are implicated many psychiatric illnesses. Interindividual variability these may manifest, at least part, as individual impulsivity both normative clinically significant levels. Impulsivity reflects a tendency towards rapid, unplanned reactions to internal or external stimuli without considering potential negative consequences coupled with difficulty inhibiting responses. Here, we use multivariate brain-based predictive models explore the bases of across multiple behavioral scales, neuroanatomical features (cortical thickness, surface area, gray matter volume), sexes (females males) large sample youth from Adolescent Brain Cognitive Development (ABCD) Study baseline (n=9,099) two-year follow-up (n=6,432). is significantly associated variability, associations vary scales features. broadly maps onto cortical thickness dispersed regions (e.g., inferior frontal, lateral occipital, superior entorhinal), well area volume specific medial parahippocampal, cingulate) polar frontal temporal) territories. Importantly, while relationships stable time points, others sex-specific dynamic. These results highlight complexity between neuroanatomy features, sexes, points youth. findings suggest that neuroanatomy, combination other biological environmental factors, key driver As such, markers help identify increased risk for developing impulsivity-related Furthermore, this work emphasizes importance adopting multidimensional approach neuroimaging research.

Language: Английский

---

Instrumental aversion coding in the basolateral amygdala and its reversion by a benzodiazepine

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: July 9, 2021

Abstract Punishment involves learning the relationship between actions and their adverse consequences. Both acquisition expression of punishment depend on basolateral amygdala (BLA), but how BLA supports remains poorly understood. To address this, we measured calcium (Ca 2+ ) transients in principal neurons during punishment. Male rats were trained to press two individually presented levers for food; when one these also yielded aversive footshock, responding this punished lever decreased relative other, unpunished lever. In with Ca indicator GCaMP6f targeted neurons, observed excitatory activity footshock punisher inhibitory lever-presses. Critically, as learned punishment, around response transformed from similarity analyses showed that lever-press resembled itself. Systemically administered benzodiazepine (midazolam) selectively alleviated Moreover, degree which midazolam was associated much response-related reverted pre-punishment state. Together, findings show is supported by aversion-coding instrumental responses anti-punishment effects benzodiazepines are a reversion aversion coding.

Language: Английский

---

The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 16, 2024

Abstract Avoidance, a hallmark of anxiety-related psychopathology, often comes at cost; avoiding threat may forgo the possibility reward. Theories predict that optimal approach-avoidance arbitration depends on threat-induced psychophysiological states, like freezing-related bradycardia. Here we used model-based fMRI analyses to investigate whether and how bradycardia states are linked neurocomputational underpinnings under varying reward magnitudes. We show associated with increased avoidance more pronounced reward-threat value comparison (i.e., stronger tendency approach vs. avoid when expected outweighs threat). An amygdala-striatal-prefrontal circuit supports threat, specific involvement amygdala dorsal anterior cingulate (dACC) in integrating states. These findings highlight role human freezing value-based decision making, relevant for coping. They point amygdala/dACC state-value integration threat.

Language: Английский

---

The role of the prefrontal cortex in cocaine-induced noradrenaline release in the nucleus accumbens: a computational study

Biological Cybernetics, Journal Year: 2025, Volume and Issue: 119(1)

Published: Feb. 7, 2025

Research has extensively explored the role of dopaminergic system in reward circuit, while contribution noradrenergic remains less understood. This study aims to fill this gap by employing computational modeling examine how medial prefrontal cortex (mPFC) influences cocaine-induced norepinephrine (NE) release nucleus accumbens shell (NAcc), with mediation tractus solitarius (NTS) and locus coeruleus (LC). The model replicates previously reported data on NE mPFC following cocaine administration. Additionally, it predicts that depletion affects NAcc through interactions NTS LC. work proposes a system-level hypothesis, suggesting regulates modulating LC NTS. These findings enhance our understanding neurochemical response offer potential directions for future addiction treatments.

Language: Английский

---

Anhedonia and Hyperhedonia in Autism and Related Neurodevelopmental Disorders

Current topics in behavioral neurosciences, Journal Year: 2022, Volume and Issue: unknown, P. 237 - 254

Published: Jan. 1, 2022

Language: Английский

---