Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders
Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Language: Английский
Revisiting the advance of age-dependent α-synuclein propagation and aggregation
Ageing and Neurodegenerative Diseases,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Feb. 22, 2025
Aging
is
a
major
risk
factor
for
different
neurodegenerative
diseases
(NDDs),
including
Parkinson’s
disease
(PD).
In
PD,
one
of
the
key
neuropathological
features
cytoplasmic
protein
aggregation,
named
Lewy
bodies
(LBs)
in
cell
body,
and
neurites
(LNs)
neuronal
processes
terminals.
The
α-synuclein
(α-syn)
has
been
found
to
be
component
LBs
LNs,
considered
play
central
role
their
formation.
α-Syn
also
increases
healthy
aging
conditions.
Evidence
shown
that
promotes
α-syn
pathological
aggregation
propagation
and,
therefore,
may
induce
aggravate
PD
pathogenesis.
Here,
we
aim
highlight
recent
advances
age-related
prion-like
discuss
subsequent
consequences
functions.
Language: Английский
Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
TDP-43
protein
is
an
RNA-binding
linked
to
amyotrophic
lateral
sclerosis,
frontotemporal
dementia,
and
Alzheimer
disease.
While
normally
a
that
shuttles
between
the
nucleus
cytoplasm,
has
recently
been
found
also
in
extracellular
vesicles.
These
are
important
medium
for
cell-cell
communication
allows
transfer
of
lipids,
proteins,
genetic
material
among
cells.
An
increasing
concern
neurodegenerative
diseases,
however,
possibility
vesicles
can
provide
effective
way
spread
misfolded
proteins
could
"infect"
other
cells
according
"prion-like"
mechanism.
To
characterize
interaction
with
lipid
membranes,
we
carried
out
systematic
biophysical
study
using
fragment
lacking
first
84
N-terminal
residues,
called
M85,
synthetic
model
phospholipid
membranes.
We
utilized
standard
techniques,
such
as
fluorescence
microscopy,
complemented
by
neutron
reflectivity
measurements.
Our
results
show
charge
affects
modality
which
M85
interacts
membranes:
higher
negative
induces
bind
bilayer
surface,
promoting
aggregation
decreasing
damage
this
causes.
Thus,
speculate
M85-lipid
membrane
play
previously
undefined
role
TDP-43-related
diseases.
Language: Английский
A case for the study of native extracellular vesicles
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 12, 2024
Three
main
areas
of
research
revolve
around
extracellular
vesicles
(EVs):
their
use
as
early
detection
diagnostics
for
cancer
prevention,
engineering
EVs
or
other
enveloped
viral-like
particles
therapeutic
purposes
and
to
understand
how
impact
biological
processes.
When
investigating
the
biology
EVs,
it
is
important
consider
strategies
able
track
alter
directly
Language: Английский
A meta-analysis of age-dependent changes in extracellular vesicle proteins in C. elegans
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
Abstract
Extracellular
vesicles
(EVs)
contribute
to
the
maintenance
of
organism-wide
proteostasis
by
mediating
intercellular
communication.
Loss
and
altered
communication
are
associated
with
aging
age-related
diseases,
suggesting
key
roles
for
EVs.
However,
it
is
unclear
how
proteome
EVs
changes
age.
To
identify
EV-associated
proteins
(EVAPs)
their
fate
age,
we
curated
publicly
available
data
from
C.
elegans
model
organism.
Our
analysis
reveals
that
carry
involve
protein
quality
control.
We
found
abundance
EV
significantly
Many
these
also
aggregate
age
overlap
Aβ
driven
aggregates.
observe
a
subset
alter
in
response
heat
stress
pathogen
infections
Further,
human
orthologs
EVAPs
brain
tissues
affected
Alzheimer’s
disease.
This
meta-analysis
highlights
composition,
changes,
aggregation
during
aging,
disease
conditions.
Overall,
this
study
provides
new
insights
into
dynamics
may
possibly
help
identifying
potential
biomarkers
diseases.
Language: Английский