Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia DOI Creative Commons
Sebastián Díaz-Pérez, Jonathan H. DeLong, Cyprien Rivier

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause globally. VaD may be caused ischemic strokes, intracerebral hemorrhage, and/or cerebral small vessel disease, commonly identified as white matter hyperintensities on MRI. The mechanisms underlying these lesions in periventricular brain are poorly understood. In this study we perform an extensive transcriptomic analysis human postmortem patients with goal identifying molecular pathways disease. We find increased cellular stress responses astrocytes, oligodendrocytes, oligodendrocyte precursor cells well transcriptional translational repression microglia our dataset. show that several genes GWAS being associated differentially expressed VaD. Finally, compare dataset independent snRNAseq PVWM scRNAseq iPSC-derived exposed oxygen glucose deprivation (OGD). identify increase heat shock protein response conserved feature across celltypes not linked OGD exposure. Overall, first common lesioned represent potential therapeutic target.

Language: Английский

Del Río Hortega’s insights into oligodendrocytes: recent advances in subtype characterization and functional roles in axonal support and disease DOI Creative Commons
Eneritz López-Muguruza,

Carla Peiró-Moreno,

Fernando Pérez‐Cerdá

et al.

Frontiers in Neuroanatomy, Journal Year: 2025, Volume and Issue: 19

Published: March 12, 2025

Pío Del Río Hortega (1882–1945) was a giant of modern neuroscience and perhaps the most impactful member Cajal’s School. His contributions to clarifying structure nervous system were key understanding brain beyond neurons. He uncovered microglia oligodendrocytes, latter until then named mesoglia. Most importantly, characterization oligodendroglia subtypes he made has stood omics revolution that added molecular details relevant comprehend their biological properties. Astounding as it may seem on today’s eyes, postulated century ago oligodendrocytes provide trophic support axons, an idea is now doubt under scrutiny dysfunction at axon-myelin unit neurodegeneration. Here, we revised recent advancements in oligodendrocyte biology shed light Hortega’s ideas ago.

Language: Английский

Citations

0
Novel Indole and Pyrrolopyridine Derivatives as GPR17 Modulators for Treating Multiple Sclerosis DOI
Ram W. Sabnis

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Pathology and Treatments of Alzheimer’s Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes DOI Creative Commons
Hidekatsu Yanai,

Hiroki Adachi,

Mariko Hakoshima

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5936 - 5936

Published: Dec. 16, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive dysfunction, memory decline, and behavioral disturbance, it pathologically characterized by the accumulation of amyloid plaques neurofibrillary tangles in brain. Although various hypotheses have been proposed to explain pathogenesis AD, including beta hypothesis, oxidative stress abnormal phosphorylation tau proteins, exact pathogenic mechanisms underlying AD remain largely undefined. Furthermore, effective curative treatments are very limited. Epidemiologic studies provide convincing evidence for significant association between type 2 diabetes AD. Here, we showed energy metabolism using glucose, lactate, ketone bodies, lipids as substrates normal brain, changes such due diabetes. We also influences altered on pathology comprehensively searched risk factors related possible therapeutic interventions based considering brain development

Language: Английский

Citations

1
The Role of Cardiolipin in Brain Bioenergetics, Neuroinflammation, and Neurodegeneration DOI
Patrick C. Bradshaw, Jessa L. Aldridge,

Leah E. Jamerson

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Language: Английский

Citations

0
Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia DOI Creative Commons
Sebastián Díaz-Pérez, Jonathan H. DeLong, Cyprien Rivier

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause globally. VaD may be caused ischemic strokes, intracerebral hemorrhage, and/or cerebral small vessel disease, commonly identified as white matter hyperintensities on MRI. The mechanisms underlying these lesions in periventricular brain are poorly understood. In this study we perform an extensive transcriptomic analysis human postmortem patients with goal identifying molecular pathways disease. We find increased cellular stress responses astrocytes, oligodendrocytes, oligodendrocyte precursor cells well transcriptional translational repression microglia our dataset. show that several genes GWAS being associated differentially expressed VaD. Finally, compare dataset independent snRNAseq PVWM scRNAseq iPSC-derived exposed oxygen glucose deprivation (OGD). identify increase heat shock protein response conserved feature across celltypes not linked OGD exposure. Overall, first common lesioned represent potential therapeutic target.

Language: Английский

Citations

0