Association between serum sodium and sporadic Parkinson’s disease

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 25, 2025

Background The correlation between serum sodium and sporadic Parkinson’s disease remains unclear currently. This study aimed to assess the association disease. Objective ultimate goal is gain a deeper understanding of implications this relationship Methods We conducted retrospective cross-sectional involving 1,189 participants in PPMI cohort. Age, sex, education years, race, body mass index, calcium, alanine aminotransferase, aspartate white blood cell, lymphocytes, neutrophils, monocytes, red hemoglobin, platelets, total protein, albumin, uric acid, sodium, potassium, urea nitrogen, creatinine, glucose were obtained from all participants. Logistic regression, smooth curve fitting utilized substantiate research objectives. Results overall was 77.5% (921/1189); it 71.9% (143/199), 75.4% (295/391), 76.7% (171/223), 83% (312/376) for quantile1 (Q1, 130–138.9 mmol/L), quantile 2 (Q2, 139–140.9 3 (Q3, 141–141.9 4 (Q4, 142–155 respectively ( p = 0.011). Multivariate odds ratio regression adjusted risk factors demonstrates 1-unit increment raises by 1.11 times, respectively. Smooth splines analysis suggested linear levels (P nonlinearity 0.5). An interaction observed sex their influence on < 0.05). Further exploratory subgroup within age BMI groups showed that there no significant interactions subgroups (all values > Additional sensitivity analyses supported primary findings indicated conclusions are robust. Conclusion highlights inappropriate incident disease, independent confounders. link linear.

Language: Английский

From Immune Activation to Disease Progression: Unraveling the Complex Role of Serum Amyloid A Proteins

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский