Activity of Human-Specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome DOI Creative Commons

Alexandria Anding,

Baiyan Ren,

Ragunathan Padmashri

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Astrocytes, a type of glial cells, have multiple roles in regulating neuronal development and homeostasis. In addition to the typical mammalian astrocytes, primate cortex interlaminar astrocytes are located superficial layer project long processes traversing layers cerebral cortex. Previously, we described human stem cell based chimeric mouse model where develop. Here, utilized this study calcium signaling properties astrocytes. To determine how could contribute neurodevelopmental disorders, generated for Fragile X syndrome. We report that FXS exhibit hyperexcitable cause an increase dendritic spine dynamics.

Language: Английский

Activity of Human-Specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome DOI Creative Commons

Alexandria Anding,

Baiyan Ren,

Ragunathan Padmashri

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Astrocytes, a type of glial cells, have multiple roles in regulating neuronal development and homeostasis. In addition to the typical mammalian astrocytes, primate cortex interlaminar astrocytes are located superficial layer project long processes traversing layers cerebral cortex. Previously, we described human stem cell based chimeric mouse model where develop. Here, utilized this study calcium signaling properties astrocytes. To determine how could contribute neurodevelopmental disorders, generated for Fragile X syndrome. We report that FXS exhibit hyperexcitable cause an increase dendritic spine dynamics.

Language: Английский

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