The Causal Relationship Between Acne Vulgaris and BMI: A Mendelian Randomization Study DOI Creative Commons
Li Z, Weili Qi, Tianying Zang

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 1, 2025

As an inflammatory skin condition, acne usually presents with a complex pathogenesis. Recent studies suggest that BMI may relate to the incidence of acne. Mendelian randomization is statistical method used evaluate causal effects exposure factors on outcome variables. We applied inverse-variance weighted (IVW) effect as primary analysis between and in our two-sample study. included 58 SNPs accounting for 2.5% (R2) variation instrumental variables (IVs) BMI-acne estimations. The F-statistic obtained from first stage MR regression model was 61. Importantly, results all three methods consistently indicated increase did not elevate risk acne, each result reaching significance. Cochran's Q test revealed no evidence heterogeneity among IV estimates individual variants. Our I2 values suggested low heterogeneity, thereby reinforcing reliability estimates. Additionally, "leave-one-out" confirmed single SNP disproportionately affected IVW point estimate. findings there relationship

Language: Английский

The Causal Relationship Between Acne Vulgaris and BMI: A Mendelian Randomization Study DOI Creative Commons
Li Z, Weili Qi, Tianying Zang

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 1, 2025

As an inflammatory skin condition, acne usually presents with a complex pathogenesis. Recent studies suggest that BMI may relate to the incidence of acne. Mendelian randomization is statistical method used evaluate causal effects exposure factors on outcome variables. We applied inverse-variance weighted (IVW) effect as primary analysis between and in our two-sample study. included 58 SNPs accounting for 2.5% (R2) variation instrumental variables (IVs) BMI-acne estimations. The F-statistic obtained from first stage MR regression model was 61. Importantly, results all three methods consistently indicated increase did not elevate risk acne, each result reaching significance. Cochran's Q test revealed no evidence heterogeneity among IV estimates individual variants. Our I2 values suggested low heterogeneity, thereby reinforcing reliability estimates. Additionally, "leave-one-out" confirmed single SNP disproportionately affected IVW point estimate. findings there relationship

Language: Английский

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