Fatigue outcomes following COVID-19: a systematic review and meta-analysis

BMJ Open, Journal Year: 2023, Volume and Issue: 13(4), P. e063969 - e063969

Published: April 1, 2023

Objectives Fatigue is a pervasive clinical symptom in coronaviruses and may continue beyond the acute phase, lasting for several months or years. This systematic review meta-analysis aimed to incorporate current evidence postinfection fatigue among survivors of SARS-CoV-2 investigate associated factors. Methods Embase, PsyINFO, Medline, CINAHL, CDSR, Open Grey, BioRxiv MedRxiv were systematically searched from January 2019 December 2021. Eligible records included all study designs English. Outcomes vitality adults with confirmed diagnosis measured at >30 days post infection. Non-confirmed cases excluded. JBI risk bias was assessed by three reviewers. Random effects model used pooled proportion 95% CIs. A mixed meta-regression 35 prospective articles calculated change overtime. Subgroup analyses explored specific group characteristics methodology. Heterogeneity using Cochran’s Q I 2 statistic. Egger’s tests publication bias. Results Database searches returned 14 262 records. Following deduplication screening, 178 identified. 147 (n=48 466 participants) meta-analyses. Pooled prevalence 41% (95% CI: 37% 45%, k=147, =98%). significantly reduced over time (−0.057, −107 −0.008, k=35, =99.3%, p=0.05). higher found studies valid scale (51%, 43% 58%, k=36, =96.2%, p=0.004). No significant difference design (p=0.272). test indicated except scales. Quality assessments 4% low bias, 78% moderate 18% high risk. Frequently reported associations female gender, age, physical functioning, breathlessness psychological distress. Conclusion revealed that experienced following their Non-modifiable factors morbidity contribute ongoing impede recovery. PROSPERO registration number CRD42020201247.

Language: Английский

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Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

Background Post-acute coronavirus disease 2019 (COVID-19) symptoms occurred in most of the COVID-19 survivors. However, few studies have examined issue whether hospitalization results different post-acute symptom risks. This study aimed to compare potential long-term effects hospitalized and non-hospitalized Methods is designed as a systematic review meta-analysis observational studies. A search six databases was performed for identifying articles published from inception until April 20th, 2022, which compared risk survivors using predesigned strategy included terms SARS-CoV-2 (eg, COVID, , 2019-nCoV ), Syndrome post-COVID, post COVID conditions, chronic symptom, long long-haul sequelae, convalescence persistent ( hospitalized, hospital home-isolated ). The present conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020 statement R software 4.1.3 create forest plots. Q statistics I 2 index were used evaluate heterogeneity this meta-analysis. Results Six Spain, Austria, Switzerland, Canada, USA involving 419 742 included. number ranged 63 431, follow-up data collected through visits four another two an electronic questionnaire, visit telephone, respectively. Significant increase risks dyspnea (OR = 3.18, 95% CI 1.90–5.32), anxiety 3.09, 1.47–6.47), myalgia 2.33, 1.02–5.33), hair loss 2.76, 1.07–7.12) found with outpatients. Conversely, persisting ageusia significantly reduced than patients. Conclusion findings suggested that special attention patient-centered rehabilitation service based on needs survey should be provided who experienced high risk.

Language: Английский

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How do long COVID patients perceive their current life situation and occupational perspective? Results of a qualitative interview study in Germany

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: March 9, 2023

Introduction Many people experience persistent or new-onset symptoms such as fatigue cognitive problems after an acute infection with COVID-19. This phenomenon, known long COVID, impacts physical and mental wellbeing, may affect perceived quality of life occupational perspectives likewise. The aim this study is to gain a deeper understanding how COVID health-related restrictions in their daily situation, identify key challenges they face. Methods Guided qualitative interviews were conducted 25 COVID. transcribed according Dresing/Pehl Kuckartz analyzed using content analysis. Afterward, systematic comparison the data reflection under consideration lifeworld-theoretical approaches (Berger Luckmann) carried out. Results revealed that many participants have severe which strongly impair them perform work-related activities, personal interests. interviewees already reach stress limit during routine household activities childcare. Of participants, 19 experienced limitations pursuing leisure 10 23 jobs reported being on sick leave for several months. Several respondents who had vocational reintegration are still affected by ongoing work performance considerably. leads uncertainty, role conflicts, decline social contacts, decreased incomes, contribute impairment life. Conclusions shows huge need specific support different areas To prevent from finding themselves economic precarity, decision-makers should develop strategies systematically sustainable into workforce. focus be creating COVID-sensitive workplaces, compensating improving access relief services reintegration. We argue, shift necessary considered rather “social disease” considerably impairments those affected. Trial registration registered German register clinical trials (DRKS00026007).

Language: Английский

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“There is no one who helps you with it”: experiences of people with long COVID regarding medical care, therapeutic measures, and barriers in the German healthcare system: results of a qualitative study with four focus groups

BMC Health Services Research, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 26, 2023

Many people experience long-term symptoms such as fatigue, cognitive problems, or shortness of breath after an acute infection with COVID-19. This emerging syndrome, known long COVID, is new and complex in many aspects. study aims to collect the experiences COVID ambulatory healthcare structures.Four focus groups were conducted a total 23 adults June July 2022. These discussions audio-recorded, subsequently transcribed, analyzed using qualitative content analysis Mayring Kuckartz.Fourteen out 19 participants who had primary care encounter regarding their did not perceive it helpful. respondents reported that general practitioners take seriously refer them specialists made therapeutic recommendations. However, some they prescribed non-pharmaceutical therapies (e.g., group meetings supported by psychotherapists, occupational therapy, etc.) improved condition. 14 perceived barriers providers' lack awareness poor access specialists, specialized clinics), high bureaucratic hurdles for specific services. To improve medical care, suggested campaigns raise among providers population, increase research government investments development treatment structures expanding existing services, establishing one-stop shops integrated specialist COVID.Several implications professionals policymakers can be derived from this study: (1) should seriously, assume coordinating role, make referrals, establish contact clinics; (2) planners on developing interprofessional evidence-based approaches COVID; (3) outpatient clinics expanded. The overarching goal must develop consistent guidelines diagnosis, treatment.The registered German register clinical trials (DRKS00026007, first registration 09/09/2021).

Language: Английский

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Psychological and Cognitive Effects of Long COVID: A Narrative Review Focusing on the Assessment and Rehabilitative Approach

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(21), P. 6554 - 6554

Published: Nov. 4, 2022

Long COVID is a clinical syndrome characterized by profound fatigue, neurocognitive difficulties, muscle pain, weakness, and depression, lasting beyond the 3–12 weeks following infection with SARS-CoV-2. Among symptoms, psychiatric sequelae, including attention memory alterations, as well anxiety depression have become major targets of current healthcare providers given significant public health impact. In this context, assessment tools play crucial role in early screening cognitive alterations due to COVID. others, general tools, such Montreal Cognitive assessment, more specific ones, State Trait Inventory Fatigue Digit Span, may be help investigating main alterations. Moreover, appropriate neurorehabilitative programs using methods techniques (conventional and/or advanced) through multidisciplinary team are required treat COVID-19-related behavioral abnormalities. narrative review, we sought describe symptoms provide some advice for treatment

Language: Английский

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Long COVID management: a mini review of current recommendations and underutilized modalities

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 14, 2024

Long COVID is a condition that develops in subset of patients after COVID-19 infection comprising symptoms varying severity encompassing multiple organ systems. Currently, long without consensus on formal definition, identifiable biomarkers, and validated treatment. expected to be long-term chronic for associated with suffering incapacity. There an urgent need clear management guidelines the primary care provider, who essential bridging gap more specialized improve quality life functionality their living COVID. The purpose this mini review provide providers latest highlights from existing literature regarding most common current recommendations. This also underutilized interventions stellate ganglion blocks low-dose naltrexone, both well-established safety profiles demonstrated some COVID, encourages prompt referral interventional pain management.

Language: Английский

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Evolution of musculoskeletal symptoms in Long COVID syndrome: a lexical analysis to approach requirements for an interdisciplinary management.

Joint Bone Spine, Journal Year: 2023, Volume and Issue: 91(1), P. 105623 - 105623

Published: July 22, 2023

Language: Английский

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The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19

NeuroImage, Journal Year: 2025, Volume and Issue: 306, P. 121011 - 121011

Published: Jan. 9, 2025

Language: Английский

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Health and social service provider perspectives on challenges, approaches, and recommendations for treating long COVID: a qualitative study of Canadian provider experiences

BMC Health Services Research, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

Many people who contract the SAR-CoV-2 virus present with multiple persistent and debilitating physical, cognitive mental health symptoms that endure beyond acute infection period. This new syndrome - generally referred to as long COVID negatively affects patients' emotional wellbeing quality of life, presents a major challenge for treatment providers. Considering lack evidence-based supports, this qualitative descriptive study explores experiences Canadian social service providers working individuals COVID, well their suggestions intervention development. Twenty between ages 29 57 across Canada completed virtual individual interviews discuss care recommendations COVID. Participants were from range sectors, including primary care, rehabilitation, health, community support. Interviews recorded, transcribed, analyzed using codebook thematic analysis. Four themes illustrated providers' (1) selecting personalized treatments based on patient presentation similar conditions amidst uncertainty; services, (2) building an integrated model care; (3) providing holistic support patients families through psychoeducation daily living resources; (4) caring in are adopting approaches address symptom persistence face considerable knowledge gap. A comprehensive, pathway is needed physical psychosocial while increasing provider preparedness treat complex condition.

Language: Английский

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Overview of Long COVID: Navigating the Aftermath

Journal of Brown Hospital Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

The coronavirus disease (COVID-19) pandemic was a global health crisis with far-reaching consequences. Among these were physical and mental complications that emerged weeks or even months after the initial COVID-19 infection, collectively termed “long COVID” “post-COVID syndrome.” Identifying epidemiology, risk factors, clinical manifestations, management strategies for long COVID is crucial both clinicians patients, which focus of this review. prevalence varies across studies, generally ranging from 5% to 20%. Prominent factors include female sex, older age, high number acute symptoms, lower socioeconomic status, underlying comorbidities such as diabetes, asthma, chronic obstructive pulmonary disease. manifestations are diverse; beyond commonly reported symptoms fatigue, malaise, ageusia, anosmia, neuropsychiatric headache, cognitive deficits, depression also potential outcomes. Although there currently no consensus on COVID, multidisciplinary care teams appropriate referrals follow-up diagnostic studies essential in evaluating course patients.

Language: Английский

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