Life,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1316 - 1316
Published: June 2, 2023
The
aim
of
this
pilot
study
was
to
investigate
whether
single
nucleotide
polymorphisms
(SNP)
in
the
gene
encoding
catalytic
subunit
glutamate
cysteine
ligase
(GCLC)
are
associated
with
risk
and
clinical
features
psoriasis.
A
total
944
unrelated
individuals,
including
474
patients
a
diagnosis
psoriasis
470
healthy
controls,
were
recruited
for
study.
Six
common
SNPs
GCLC
genotyped
using
MassArray-4
system.
Polymorphisms
rs648595
(OR
=
0.56,
95%
CI
0.35-0.90;
Pperm
0.017)
rs2397147
0.54,
0.30-0.98;
0.05)
susceptibility
males.
In
male
group,
diplotype
rs2397147-C/C
×
rs17883901-G/G
decreased
(FDR-adjusted
p
0.014),
whereas
rs6933870-G/G
0.045)
showed
an
association
increased
disease
females.
joint
effects
tobacco
smoking
(rs648595
rs17883901)
alcohol
abuse
rs542914)
on
observed
(Pperm
≤
0.05).
We
also
found
multiple
sex-independent
associations
between
various
such
as
earlier
onset,
psoriatic
triad,
specific
localizations
skin
lesions.
present
is
first
show
that
significantly
related
its
features.
Journal of Clinical Cardiology,
Journal Year:
2024,
Volume and Issue:
5(1), P. 6 - 29
Published: Jan. 5, 2024
Cardiovascular
diseases
(CVDs)
remain
a
leading
cause
of
morbidity
and
mortality
worldwide.
Effective
prevention
management
strategies
are
essential
to
reduce
the
burden
CVDs.
This
review
summarizes
recent
advances
in
In
terms
prevention,
lifestyle
modifications,
such
as
diet,
exercise,
smoking
cessation,
important
strategies.
Pharmacological
interventions,
including
statins,
antiplatelet
agents,
antihypertensive
medications,
have
also
shown
benefits.
Innovative
approaches,
genetic
testing
risk
stratification,
targeted
strategies,
use
mobile
health
technology,
being
explored.
management,
acute
reperfusion
therapy
for
myocardial
infarction,
heart
failure
stroke
improved
outcomes.
Chronic
medical
failure,
arrhythmia
device
precision
medicine
personalized
treatment,
artificial
intelligence
diagnosis
traditional
Chinese
regenerative
medicine,
investigated.
While
CVDs
promising,
challenges
implementing
these
cost-effectiveness,
access
care,
resistance
change
clinical
practice.
Continued
research
innovation
improve
patient
Aging Clinical and Experimental Research,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: Feb. 22, 2025
Abstract
Background
A
variety
of
unsupervised
learning
algorithms
have
been
used
to
phenotype
older
patients,
enabling
directed
care
and
personalised
treatment
plans.
However,
the
ability
clusters
accurately
discriminate
for
risk
may
vary
depending
on
methods
employed.
Aims
To
compare
seven
clustering
in
their
develop
patient
phenotypes
that
predict
health
outcomes.
Methods
Data
was
collected
N
=
737
medical
inpatients
during
hospital
stay
five
different
types
data
(ICD-10
codes,
ATC
drug
laboratory,
clinic
frailty
data).
We
trialled
(K-means,
K-modes,
hierarchical
clustering,
latent
class
analysis
(LCA),
DBSCAN)
two
graph-based
approaches
create
separate
each
method
datatype.
These
were
as
input
a
random
forest
classifier
eleven
outcomes:
mortality
at
one,
three,
six
12
months,
in-hospital
falls
delirium,
length-of-stay,
outpatient
visits,
readmissions
three
months.
Results
The
overall
median
area-under-the-curve
(AUC)
across
outcomes
(from
highest
lowest)
0.758
(hierarchical),
0.739
(K-means),
0.722
(KG-Louvain),
0.704
(KNN-Louvain),
0.698
0.694
(DBSCAN)
0.656
(K-modes).
Overall,
most
important
type
predicting
mortality,
ICD-10
disease
codes
readmissions,
laboratory
falls.
Conclusions
Clusters
created
using
hierarchical,
K-means
Louvain
community
detection
identified
well-separated
consistently
associated
with
age-related
adverse
Frailty
valuable
Journal of Internal Medicine,
Journal Year:
2023,
Volume and Issue:
294(4), P. 437 - 454
Published: July 17, 2023
The
technical
development
of
high-throughput
sequencing
technologies
and
the
parallel
targeted
therapies
in
last
decade
have
enabled
a
transition
from
traditional
medicine
to
personalized
treatment
care.
In
this
way,
by
using
comprehensive
genomic
testing,
more
effective
treatments
with
fewer
side
effects
are
provided
each
patient-that
is,
precision
or
(PM).
several
European
countries-such
as
England,
France,
Denmark,
Spain-the
governments
adopted
national
strategies
taken
"top-down"
decisions
invest
infrastructure
for
PM.
other
Sweden,
Germany,
Italy
regionally
organized
healthcare
systems-the
profession
has
instead
"bottom-up"
initiatives
build
competence
networks
enable
equal
access
review,
we
summarize
key
learnings
at
level
on
implementation
process
establish
sustainable
governance
organization
PM
regional,
national,
EU/international
levels.
We
also
discuss
critical
ethical
legal
aspects
implementing
PM,
importance
real-world
data
performing
clinical
trials
evidence
generation,
well
need
improved
reimbursement
models,
increased
cross-disciplinary
education
patient
involvement.
summary,
represents
paradigm
shift,
modernization
all
relevant
stakeholders-that
healthcare,
academia,
policymakers,
industry,
patients-must
be
involved
system
transformation
create
sustainable,
non-siloed
ecosystem
that
benefits
our
patients
society
large.
Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
96(7), P. 543 - 551
Published: Jan. 5, 2024
Precision
medicine
has
the
ambition
to
improve
treatment
response
and
clinical
outcomes
through
patient
stratification,
holds
great
potential
in
mental
disorders.
However,
several
important
factors
are
needed
transform
current
practice
into
a
"precision
psychiatry"
framework.
Most
(1)
generation
of
accessible
large
real-world
training
test
data
including
genomic
integrated
from
multiple
sources,
(2)
development
validation
advanced
analytical
tools
for
stratification
prediction,
(3)
clinically
useful
management
platforms
monitoring
that
can
be
healthcare
systems
real-life
settings.
This
narrative
review
summarizes
strategies
obtaining
key
elements
–
well-powered
samples
biobanks,
with
electronic
health
records
registry
using
novel
artificial
intelligence
algorithms
predict
severe
disorders
translate
these
models
approaches.
Key
massive
algorithms.
For
translation
strategies,
we
discuss
precision
platform
improved
We
include
use
cases
illustrate
how
interventions
could
brought
psychiatry
Annals of Medicine,
Journal Year:
2025,
Volume and Issue:
57(1)
Published: Jan. 18, 2025
Background
Most
older
patients
with
atrial
fibrillation
(AF)
have
comorbidities.
However,
it
is
unclear
whether
specific
comorbidity
patterns
are
associated
adverse
outcomes.
We
identified
and
their
association
mortality
in
multimorbid
AF
different
multidimensional
frailty.
American Journal of Medical Genetics Part A,
Journal Year:
2024,
Volume and Issue:
194(7)
Published: March 7, 2024
Debates
about
the
prospective
clinical
use
of
polygenic
risk
scores
(PRS)
have
grown
considerably
in
last
years.
The
potential
benefits
PRS
to
improve
patient
care
at
individual
and
population
levels
been
extensively
underlined.
Nonetheless,
contexts
presents
a
number
unresolved
ethical
challenges
consequent
normative
gaps
that
hinder
their
optimal
implementation.
Here,
we
conducted
systematic
review
reasons
literature
discussing
issues
moral
arguments
related
for
prevention
treatment
common
complex
diseases.
In
total,
included
analyzed
34
records,
spanning
from
2013
2023.
findings
organized
three
major
themes:
first
theme,
consider
harms
individuals
kin.
theme
"Threats
health
equity,"
concerns
social
relevance,
with
focus
on
justice
issues.
Finally,
"Towards
best
practices"
collects
series
research
priorities
provisional
recommendations
be
considered
an
translation
PRS.
We
conclude
reinvigorates
old
debates
matters
justice;
however,
open
questions,
regarding
practices
counseling,
suggest
considerations
applicable
monogenic
settings
will
not
sufficient
face
emerging
challenges.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 13, 2024
Abstract
The
development
of
personalized
precision
medicine
has
become
a
pivotal
focus
in
modern
healthcare.
Organoids‐on‐a‐Chip
(OoCs),
groundbreaking
fusion
organoid
culture
and
microfluidic
chip
technology,
emerged
as
promising
approach
to
advancing
patient‐specific
treatment
strategies.
In
this
review,
the
diverse
applications
OoCs
are
explored,
particularly
their
role
medicine,
potential
cutting‐edge
technology
is
highlighted.
By
utilizing
patient‐derived
organoids,
offer
pathway
optimize
treatments,
create
precise
disease
models,
investigate
mechanisms,
conduct
drug
screenings,
individualize
therapeutic
emphasis
on
significance
technological
revolutionizing
healthcare
improving
patient
outcomes.
Furthermore,
transformative
future
prospects,
ongoing
advancements
field,
with
genomic
multi‐omics
integration,
ethical
frameworks
discussed.
convergence
these
innovations
can
empower
patients,
redefine
approaches,
shape
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14912 - 14912
Published: Oct. 5, 2023
The
recent
advent
of
sophisticated
technologies
like
sequencing
and
mass
spectroscopy
platforms
combined
with
artificial
intelligence-powered
analytic
tools
has
initiated
a
new
era
"big
data"
research
in
various
complex
diseases
still-undetermined
cause
mechanisms.
investigation
these
was,
until
recently,
limited
to
traditional
vitro
vivo
biological
experimentation,
but
clear
switch
silico
methodologies
is
now
under
way.
This
review
tries
provide
comprehensive
assessment
state-of-the-art
knowledge
on
omes,
omics
multi-omics
inflammatory
bowel
disease
(IBD).
notion
importance
both
health
IBD
introduced,
followed
by
discussion
the
believed
be
relevant
pathogenesis,
how
can
generate
insights
translatable
into
useful
clinical
such
as
biomarker
identification,
prediction
remission
relapse,
response
therapy,
precision
medicine.
pitfalls
limitations
current
studies
are
critically
analyzed,
revealing
that,
regardless
types
omes
being
majority
reports
still
based
simple
associations
descriptive
retrospective
data
from
cross-sectional
patient
cohorts
rather
than
more
powerful
longitudinally
collected
prospective
datasets.
Given
this
limitation,
some
suggestions
provided
may
optimized
for
greater
therapeutic
benefit.
concludes
forecasting
upcoming
incorporation
analyses
routine
management
IBD.
