Gingival acquired lymphangiectasia as a long-term effect of post-oncology intervention: A 20-year institutional audit DOI
Pratibha Ramani,

Abilasha Ramasubramanian,

Suvarna Kizhakkoottu

et al.

Journal of Oral and Maxillofacial Pathology, Journal Year: 2024, Volume and Issue: 28(3), P. 428 - 433

Published: July 1, 2024

Gingiva is a keratinised mucosa akin to the skin and exposed in all modalities of treatment oral cancer. Acquired lymphangiectasia are acquired dilatations lymphatic channels secondary an external cause. They extremely rare cavity despite that cancers treated with different modalities.

Language: Английский

Exosomes derived from human adipose mesenchymal stem cells act as a therapeutic target for oral submucous fibrosis DOI
Kaviyarasi Renu

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102224 - 102224

Published: Jan. 1, 2025

Language: Английский

Citations

1
Aberrant expression of VASP serves as a potential prognostic biomarker and therapeutic target for oral squamous cell carcinoma DOI
K. V. Gopalakrishnan, Balachander Kannan,

Chandra Pandi

et al.

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Journal Year: 2024, Volume and Issue: 138(3), P. 391 - 402

Published: May 14, 2024

Language: Английский

Citations

4
Increased SEC14L2 expression is associated with clinicopathological features and worse prognosis in oral squamous cell carcinoma DOI

Jonah Justin David,

Balachander Kannan,

Chandra Pandi

et al.

Odontology, Journal Year: 2024, Volume and Issue: 112(4), P. 1326 - 1334

Published: April 4, 2024

Language: Английский

Citations

3
Aberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer DOI
Akshay Kumar,

B. Kannan,

Smiline Girija AS

et al.

International Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Understanding myokine Irisin’s function in oral cancer: therapeutic and prognostic consequences DOI
Kaviyarasi Renu

Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
In Silico Development of PABA-substituted Pyrimidine Derivatives Targeting Mutant p53 for Precision Therapy in Oral Squamous Cell Carcinoma DOI
Kathirvel Sekar, Kaviyarasi Renu, Sathishkumar Vinayagam

et al.

Journal of Advanced Oral Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with poor prognosis, largely attributed to p53 mutations in 65%–85% of cases. Mutant loses tumour-suppressor functions and gains oncogenic roles, promoting cancer progression therapy resistance. Targeting mutant represents promising therapeutic avenue. Aim: The aim this study was evaluate the potential 4-amino benzoic acid (PABA)-substituted pyrimidine derivatives as novel inhibitors protein through silico analyses. Method: (PDB ID: 4mzi) retrieved from RCSB Protein Data Bank. PABA (3A, 3B, 3C 3D) were assessed for drug-likeness, toxicity binding affinities using Lipinski’s Rule, PROTox-II AutoDock 4.2. Binding energies, hydrogen bonds Van der Waals interactions analysed. Result: All satisfied Rule no violations, demonstrating drug-likeness. Toxicity analysis classified compounds non-carcinogenic non-mutagenic. highest 3D (−8.8 kcal/mol) strong at PRO A: 219, GLY 199 ASN 200, forming four bonds. Compound (−7.9 also exhibited significant binding. PABA’s anti-cancer properties stable protein–ligand highlight its potential. Conclusion: PABA-substituted derivatives, particularly 3D, show promise lead targeting OSCC. Further vitro vivo studies are warranted validate their efficacy safety, paving way precision therapies.

Language: Английский

Citations

0
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma DOI Creative Commons

Shanchun Tao,

Di Cui, Huimin Cheng

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 12, 2024

Abstract Background Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated expression transforming growth factor beta regulator 4 (TBRG4) in HCC and its effects on proliferation, invasion, metastasis cells, analyzed possible molecular mechanisms. Method Downloading clinical information samples TCGA database, analyzing differences TBRG4 by bioinformatics methods, relevance prognostic significance. Performing GO, KEGG GSEA enrichment analysis TBRG4-related gene set patient tissues. Applying cell counting, scratch test Transwell experiment to study biological function HCC. Mitochondrial membrane potential, apoptosis ROS levels were evaluated assess iron death. Western blot, RT-PCR, laser confocal microscopy co-immunoprecipitation used detect analyze downstream signaling pathways interacting molecules TBRG4. Results Bioinformatics revealed that was abnormally highly expressed tissues associated prognosis patients. GO functional showed related oxidative stress NADH dehydrogenase (ubiquinone) activity. Beta catenin independent wnt B receptor. Functional experiments confirmed knocking down could inhibit migration, invasion cells. Mechanistically, inhibited cells through DDX56/p-AKT/GSK3β pathway. addition, interference reduce mitochondrial potential accumulate leading increased ferroptosis. Co-IP specifically bound Beclin1. Conclusion It may regulate interact Beclin1 ferroptosis

Language: Английский

Citations

3
Waterpipe smoke condensate induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by FOXD1 expression DOI
Prathibha Prasad, Balachander Kannan, Gopu Sriram

et al.

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: 125(4), P. 101900 - 101900

Published: April 30, 2024

Language: Английский

Citations

3
A Retrospective Analysis of the Clinicopathological Profile of Oral Squamous Cell Carcinoma in Tobacco and Non-tobacco Users: Highlighting the Significance of Chronic Mechanical Irritation DOI Open Access

Priya Thomas,

Deepu Mathew,

Kutty Anisha

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Background and aim: Oral squamous cell carcinoma (OSCC) is among the leading top three cancers in India. However, recent literature has shown an increase rise of oral cancer younger individuals without any history tobacco-related habits. Chronic mucosal irritation (CMI) been noted to have a substantial impact on development etiology OSCC. With shift trend, it imperative observe monitor alterations associated with its etiological factors. The study aims evaluate prevalence clinical characteristics OSCC patients association these parameters cases tobacco usage. Methodology: A retrospective spanning period 10 years was done histopathologically diagnosed Various clinicopathological were collected from patient records, including demographic features, habits, chewing smoking, presentation, anatomic sites, histopathological grading based inclusion exclusion criteria. data tabulated Microsoft Excel (Microsoft Corporation, Redmond, WA), descriptive statistics analysis chi-square test significance applied using IBM SPSS Statistics (version 29.0.2; Corp., Armonk, NY). correlated epidemiologic behavior age, gender, site, Results: This included sample size 204 (72 females & 132 males). Tobacco-related habit-associated 98 (48.5%) habits 61 (29.6%). Etiology CMI emerged be significant tooth-related factor. Out 72 females, 32 (44.4%) habit. caused by trauma analyzed 40 (19.6%) 22 (55%) females. majority lesions (76 (37.4%) cases) presented lateral border tongue. Among chronic mechanical irritation, 37 (48.7%) observed specifically Conclusion: These 10-year will generate awareness about disease pattern occurring within community provide overview prerequisite considering as factor for

Language: Английский

Citations

3
Dysregulation of a novel m6A regulator YWHAG is correlated with metastasis and poor prognosis in oral squamous cell carcinoma – a cross-sectional study DOI

Rithanyaa Ramesh Kumar,

Balachander Kannan,

Chandra Pandi

et al.

Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 169, P. 106090 - 106090

Published: Sept. 12, 2024

Language: Английский

Citations

2