Skeletal Phenotyping of Period‐1‐Deficient Melatonin‐Proficient Mice DOI Creative Commons
Olaf Bahlmann, S. Taheri,

Manuela Spaeth

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(8)

Published: Nov. 1, 2024

ABSTRACT In mice, variability in adult bone size and density has been observed among common inbred strains. Also, the group of genes regulating circadian rhythmicity so called clock genes, changes body skeletal parameters have noted knockout mice. Here, we studied prominent bones axial appendicular skeleton gene Period ‐1‐deficient ( Per 1 ‐/‐ ) mice by means microcomputed tomography. Our data show shorter spinal length, smaller less dense femora tibiae, but no significant shape skull length head. Together with significantly lower total weight conclude that 1‐deficiency a melatonin‐proficient mouse strain is associated an altered phenotype (hind limb) size, spine while normal head brain weight. The suggest involvement secondary mineralisation impact on long bones, lesser those skull. Evidence overall physiological implications these findings are discussed.

Language: Английский

A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice DOI Creative Commons
Guohao Han, Dan Li, Haisen Zhang

et al.

Scientific Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 3, 2025

The circadian clock regulates various physiological processes in mammals. core gene Bmal1 is crucial for maintaining the oscillations of system by controlling rhythmic expression numerous clock-controlled genes. To explore transcriptional changes associated with deletion liver tissues, we collected tissues from global and liver-specific knockout mice, along their respective control groups, at two time points (CT2 CT14) used them transcriptome sequencing analysis. Genotyping, locomotor activity analysis, comprehensive quality analyses, including base scores, GC content, mapping rates, confirmed high data. Differential analysis RT-qPCR validation reliability validity dataset. These data offer a valuable resource researchers investigating role BMAL1 physiology, pathology, broader field biology.

Language: Английский

Citations

1
Basic research on circadian disruption using animal and human organoid models: a review DOI
Hamideh Rahmati, Behzad Garmabi, Hamed Ghazvini

et al.

Biological Rhythm Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 1, 2025

Language: Английский

Citations

0
Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine DOI Creative Commons
Horst‐Werner Korf

Cell and Tissue Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

2
Melatonin Inhibits ET‐1 Production to Break Crosstalk Between Prostate Cancer and Bone Cells: Implication for Osteoblastic Bone Metastasis Treatment DOI

Liang‐Wei Lin,

Tien‐Huang Lin,

Sanskruti Swain

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(7)

Published: Oct. 1, 2024

ABSTRACT Bone metastasis is the primary cause of death among patients with advanced prostate cancer (PCa). PCa tends to spread bones and acquire bone‐like phenotype, causing osteoblastic bone metastasis. Unfortunately, there no effective treatment for this condition. However, melatonin, which regulates our circadian rhythm, has been found have anti‐tumor properties. It yet be established whether it in treating Our findings show that melatonin inhibits production endothelin‐1 (ET‐1) cells, suppressing osteoblast differentiation. Clinical results indicate metastatic higher levels ET‐1 compared nonmetastatic patients. Furthermore, melatonin‐induced miR‐let‐7f‐5p ET‐1‐promoted differentiation PCa. Melatonin also suppresses property osteomimicry cells. Importantly, intratibia injection model, decreased tumor growth, inhibiting vivo. Taken together, PCa‐regulated osteoblastogenesis by reducing through upregulation miR‐let‐7f‐5p, while therapy could a promising approach

Language: Английский

Citations

0
Effects of different monochromatic light on growth performance and liver circadian rhythm of Yangzhou geese DOI Creative Commons
Yongbing Xu, Yi Tang,

Yiyi Cheng

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104496 - 104496

Published: Nov. 12, 2024

The objective of this study is to examine the impact monochromatic light on circadian rhythms blood melatonin and insulin-like growth factor 1 (IGF-1) levels, liver clock genes, receptors. A total 144 male Yangzhou geese were randomly assigned four groups based color, with each group consisting 36 geese. provided ad libitum access food water, raised for 70 days under a photoperiod 16 hours 8 darkness. They weighed every 10 days, blood, liver, pituitary gland samples collected at six time points when reached age. findings indicated that exposure green (GL) had stimulating weight gain in geese, while not significantly affecting feed-to-weight ratio. After undergoing photochromic treatments, both plasma levels positive feedback gene expression displayed diurnal low-night high pattern, reaching their peak evening. Conversely, IGF-1 negative genes exhibited an opposite trend. However, down-regulated expression, amplitude retinoic acid receptor-related orphan receptor α (RORα), as well advancing or delaying phase rhythm. Among them, GL up-regulated receptors 1C (MEL1C); blue (BL) increased concentration decreased period 3 (PER3), resulting almost no difference PER3 times; red (RL) MEL1C peaks amplitudes seven especially locomotor output cycles kaput (CLOCK). Moreover, BL are identical, except PER3. offer theoretical framework facilitating development meat implementing logical approach managing lighting conditions.

Language: Английский

Citations

0
Chronobiological and neuroendocrine insights into dry eye DOI
Licheng Li, Haoyu Li, Baihua Chen

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Skeletal Phenotyping of Period‐1‐Deficient Melatonin‐Proficient Mice DOI Creative Commons
Olaf Bahlmann, S. Taheri,

Manuela Spaeth

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(8)

Published: Nov. 1, 2024

ABSTRACT In mice, variability in adult bone size and density has been observed among common inbred strains. Also, the group of genes regulating circadian rhythmicity so called clock genes, changes body skeletal parameters have noted knockout mice. Here, we studied prominent bones axial appendicular skeleton gene Period ‐1‐deficient ( Per 1 ‐/‐ ) mice by means microcomputed tomography. Our data show shorter spinal length, smaller less dense femora tibiae, but no significant shape skull length head. Together with significantly lower total weight conclude that 1‐deficiency a melatonin‐proficient mouse strain is associated an altered phenotype (hind limb) size, spine while normal head brain weight. The suggest involvement secondary mineralisation impact on long bones, lesser those skull. Evidence overall physiological implications these findings are discussed.

Language: Английский

Citations

0