The potential therapeutic role of melatonin in organ fibrosis: a comprehensive review DOI Creative Commons
Wei Huang, Juan Zheng, Ming Wang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 13, 2024

Organ fibrosis is a pathological process characterized by the inability of normal tissue cells to regenerate sufficiently meet dynamic repair demands chronic injury, resulting in excessive extracellular matrix deposition and ultimately leading organ dysfunction. Despite increasing depth research field more comprehensive understanding its pathogenesis, effective treatments for fibrosis-related diseases are still lacking. Melatonin, neuroendocrine hormone synthesized pineal gland, plays crucial role regulating biological rhythms, sleep, antioxidant defenses. Recent studies have shown that melatonin may potential inhibiting fibrosis, possibly due functions anti-oxidative stress, anti-inflammation, remodeling (ECM), epithelial-mesenchymal transition (EMT), apoptosis, thereby alleviating fibrosis. This review aims explore therapeutic human using findings from various vivo vitro studies. These discoveries should provide important insights further development new drugs treat

Language: Английский

Sleep and circadian disturbances in children with neurodevelopmental disorders DOI
Oliviero Bruni, Maria Breda,

Valeria Mammarella

et al.

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

2
Navigating the digital frontier: protecting adolescents in the age of mobile internet DOI
Bo Wen, Fengyan Ma, Guochao Zhang

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

1
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation DOI
Xiaoyue Li,

Yanai Chen,

Huiyan Shao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140500 - 140500

Published: Jan. 30, 2025

Language: Английский

Citations

1
Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data DOI Creative Commons

Attila Tóth,

Árpád Dobolyi

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106000 - 106000

Published: Jan. 1, 2025

The role of prolactin in sleep regulation has been the subject extensive research over past 50 years, resulting identification multiple, disparate functions for hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution light. High levels were linked to non-rapid eye movement electroencephalogram delta activity humans. Conversely, hyperprolactinemia showed strong correlation REM rodent studies. may be implicated alterations female patterns observed reproductive cycle, it play enhancement following stress sleep-related immunological processes. In conclusion, appears have sleep-promoting role, particularly phase. However, does not appear central coherent regulation, as some neuropeptides such orexin. its principal function facilitate situational, yet adaptive, changes response challenging physiological phases, those associated stress, challenges, or cycle. Neuronal substrates prolactin-mediated effects remain unknown; however, recent studies provide insights into potential sites these effects.

Language: Английский

Citations

0
UBC4: A Repurposed Drug Regimen for Adjunctive Use During Bladder Cancer Treatment DOI Creative Commons
Richard E. Kast

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 706 - 706

Published: March 13, 2025

After it has metastasized, bladder cancer, the malignant transformation of urothelium, continues to be a common cause death after maximal use all currently available standard treatments. To address this problem in 2025, drug repurposing movement within oncology aims identify medicines general medical care that have data indicating they can interfere or inhibit growth driving element been identified cancer. This paper now outlines extensive preclinical showing four drugs from practice meet these criteria—the melatonergic ramelteon, antidepressant fluoxetine, antibiotic dapsone, and analgesic celecoxib. is UBC4 regimen, meant as possible adjunct added treatments metastatic Three factors justify clinical pilot trial UBC4: (1) are usually well tolerated carry low risk harm, (2) commonly fatal outcome cancer once widely plus (3) strong database UBC inhibition by each individual outlined paper.

Language: Английский

Citations

0
Circadian Rhythm Disruption and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis DOI Creative Commons

Tara Heydari,

Prakash V. A. K. Ramdass

AJOG Global Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100479 - 100479

Published: March 1, 2025

The aim of our systematic review and meta-analysis was to determine if circadian rhythm disruption (CRD) is associated with polycystic ovary syndrome (PCOS). Our objective pool the overall mean differences in biomarkers CRD (including melatonin levels, morning evening cortisol sleep efficiency) between PCOS patients controls. We hypothesized that will be more prominent PCOS. A search PubMed, Scopus, Embase, ClinicalTrials.Gov, Cochrane Database Systematic Reviews conducted from inception until 2024 using following MeSH terms "circadian rhythm" OR "sleep disturbance" "melatonin" AND "polycystic syndrome." Citation supplemented database search. Inclusion criteria were women PCOS, original case-control, cross-sectional, cohort studies identify parameters (melatonin, cortisol, disturbance). Exclusion endocrine metabolic co-morbidities, menopausal women, case reports, studies, animal abstracts, conference presentations. There no time restriction for year publication. Two investigators (T.H. P.R.) assessed quality included Newcastle-Ottawa Scale. Forest plots created Open Meta Analyst software. Publication bias Egger's Begg's tests. total 16 12 (N=1,100 [531 569 controls]). Pooled analysis showed difference levels controls 14.294 pg/mL, 95% CI [6.895, 21.693]. 1.103 [-1.058, 3.265], 3.574 [1.741, 5.407], respectively. efficiency scores -4.059, [-6.752, -1.366]. Risk assessment NOS ranged 7 9. provides evidence positively syndrome. This substantiated by indicative disruption, including efficiency.

Language: Английский

Citations

0
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook DOI Creative Commons

Rhearne C. Ryan,

Mathew N. Leslie,

Patrick He

et al.

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115575 - 115575

Published: April 1, 2025

Synchronisation of the suprachiasmatic nucleus (SCN) driven endogenous clock, located within central nervous system (CNS), and exogenous time cues, is essential for maintaining circadian rhythmicity, homeostasis overall wellbeing. Disordered rhythms have been associated with various conditions, inclusive neurodegenerative disorders, such as Alzheimer's disease Parkinson's disease. Traditional pharmacological approaches to dysfunction in disorders primarily focused on oral drug delivery. Oral medications often face challenges achieving necessary systemic circulation effectively bypass blood brain barrier (BBB) reach CNS, due low or variable bioavailability. Advancements non-invasive delivery methods, orally inhaled intranasal formulations, present promising alternatives targeting CNS. Orally allows rapidly achieve high through increased bioavailability fast onset action. Additionally, therapies BBB olfactory trigeminal nerve pathways directly enter This review assesses potential treat conditions. In addition, this will explore melatonin an example enhancing therapeutic outcomes by adopting formulations improve absorption target disorder more effectively.

Language: Английский

Citations

0
Sleep-promoting mechanism of Lactobacillus plantarum P8 combined with traditional Chinese medicine revealed by network pharmacology, microbiome, metabolome, and transcriptome analyses DOI
Boyuan Guan, Xiayu Liu, Ziyi Hu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106606 - 106606

Published: April 1, 2025

Language: Английский

Citations

0
Melatonin Mitigates Sleep Restriction-Induced Cognitive and Glymphatic Dysfunction Via Aquaporin-4 Polarization DOI
Huaiqing Sun, Qiuchen Cao,

Xiaoxin He

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Association between perfluoroalkyl and polyfluoroalkyl substances and adolescents' sleep disorders: NHANES 2005–2018 DOI Creative Commons
Bo Gao, Yanju Gong, Yan Lu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Background Previous research indicates that per- and polyfluoroalkyl substances (PFAS) can disrupt metabolism neurological function via endocrine pathway interference neuroinflammation. These effects may impair melatonin secretion circadian rhythm regulation, suggesting potential links to sleep health. However, the impact of PFAS exposure on adolescent remains unclear. This study examines associations between health indicators in U.S. adolescents. Methods Data from 838 adolescents who participated 2005–2018 National Health Nutrition Examination Survey (NHANES) were analyzed investigate association physician-diagnosed disorders. Eight compounds identified. Multivariate logistic regression models, restricted cubic spline (RCS) curves, Bayesian kernel machine (BKMR), weighted quantile sum (WQS) used assess single, linear, combined Results Negative observed disorders three compounds, specifically perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorononanoic (PFNA). RCS analysis revealed a significant linear relationship ( P for non-linear > 0.05). The BKMR WQS models demonstrated effect disorders, with PFOS demonstrating most substantial contribution (effect size: 0.91). stratified had greater females [odds ratio (OR): 0.54, 95% confidence interval (CI): 0.33–0.87] than males (OR: 0.50, CI: 0.24–1.01), sex-specific differences vulnerability. Conclusions Our findings indicate negative correlation specific adolescents, being dominant component mixture stronger females. due cross-sectional nature study, causal cannot be established. results highlight public need further underlying mechanisms pathways future longitudinal or experimental studies.

Language: Английский

Citations

0