The Triad of Sleep, Immunity, and Cancer: A Mediating Perspective

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1246 - 1246

Published: July 24, 2024

The triadic interplay between sleep, immunity, and cancer represents a growing area of biomedical research with significant clinical implications. This review synthesizes the current knowledge on how sleep influences immune function, system’s role in dynamics, direct connections patterns risk. After comprehensive overview interrelationships among these three domains, mechanisms function are described, detailing regulates system, effects duration quality responses, underlying molecular cellular mechanisms. Also, complex relationship immunity is explored, highlighting prevention progression, surveillance, tumor microenvironment, implications immunodeficiency modulation then presenting epidemiological evidence linking to risk, biological that influence development, disorders prognosis. mediating highlighted, proposing hypothesized pathways, summarizing from experimental studies, evaluating impact interventions outcomes. concludes by discussing future directions, emphasizing potential for sleep-based treatment, integration management oncology immunotherapy, outlining agenda. agenda includes understanding sleep–immunity–cancer interplay, conducting studies assessing treatment protocols, exploring microenvironment interactions, considering policy public health Through detailed examination interconnected this underscores critical importance modulating outcomes, advocating interdisciplinary strategies harness improved

Language: Английский

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Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities

Neuropharmacology, Journal Year: 2023, Volume and Issue: 245, P. 109815 - 109815

Published: Dec. 17, 2023

Orexin is a neurotransmitter produced by small group of hypothalamic neurons. Besides its well-known role in the regulation sleep-wake cycle, orexin system was shown to be relevant several physiological functions including cognition, mood and emotion modulation, energy homeostasis. Indeed, implication neurotransmission neurological psychiatric diseases has been hypothesized via direct effect exerted projections neurons brain areas, an indirect through orexin-mediated modulation sleep wake. Along with growing evidence concerning use dual receptor antagonists (DORAs) treatment insomnia, studies assessing their efficacy insomnia comorbid have set order investigate potential impact DORAs on both sleep-related symptoms disease-specific manifestations. This narrative review aimed at summarizing current conditions also discussing possible modulating for improving burden pathological mechanisms these disorders. Target searches were performed PubMed/MEDLINE Scopus databases ongoing registered Clinicaltrials.gov reviewed. Despite some contradictory findings, preclinical seemingly support beneficial antagonism management most common comorbidities. However, clinical research still limited further are needed corroborating promising preliminary results.

Language: Английский

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Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2023, Volume and Issue: 2(2), P. 14 - 26

Published: April 5, 2023

Although while getting a restful night's sleep is essential for your mental and physical health, insomnia very prevalent. More people are turning to complementary alternative therapies treat or prevent sleeplessness. For hundreds of years, herbal treatments like valerian, passionflower, lemon balm, lavender, California poppy have been utilized successfully. After using these medicines, latency was reduced subjective objective measures quality improved. Their sedative sleep-inducing effects caused by interactions with several neurotransmitter systems in the brain, according molecular research. The plant species can be divided into 76 different genera 32 families, Asteraceae (24.2%) Lamiaceae (21.1%) being most prevalent subgroups. Leaves (29%) flowers (27%), respectively, used make majority infusions (70%) decoctions (25%). Just well-known taxa—out 106 known—are treated here (A. arvensis L., C. nepeta monogyna Jacq., H. lupulus L. nobilis angustifolia Mill., M. sylvestris chamomilla officinalis O. basilicum P. rhoeas somniferum R. T. platyphyllus Scop., V. L.). Further study required confirm therapeutic potential substitutes define mechanism action bioactive compounds because only seven fifteen chosen investigated pharmacological activity as hypnotic-sedatives.

Language: Английский

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Insomnia, poor sleep quality and perinatal suicidal risk: A systematic review and meta‐analysis

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 33(2)

Published: July 13, 2023

Summary Suicidal risk in mothers is a public health priority. Risk factors include biological, psychological and psychosocial factors. Among the biological factors, role of sleep disturbances as potential contributors to increased suicidal during peripartum period becoming apparent. To explore this further, we conducted systematic review following PRISMA criteria. Currently, 10 studies have examined insomnia poor quality involved 807,760 women. The data showed that disturbed increase ideation both pregnant women with without perinatal depression. results meta‐analysis indicated odds by more than threefold (OR = 3.47; 95% CI: 2.63–4.57). Specifically, ratio (OR) for was 3.72 (95% 2.58–5.34; p < 0.001), symptoms, after taking into account depression, 4.76 1.83–12.34; 0.001). These findings emphasise importance assessing addressing mitigate their adverse effects on psychopathology risk.

Language: Английский

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The effectiveness of the behavioural components of cognitive behavioural therapy for insomnia in older adults: A systematic review

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 32(4)

Published: Feb. 19, 2023

Insomnia is more prevalent in older adults (> 60 years) than the general population. Cognitive behavioural therapy for insomnia gold-standard treatment; however, it may prove too cognitively taxing some. This systematic review aimed to critically examine literature exploring effectiveness of explicitly interventions adults, with secondary aims investigating their effect on mood and daytime functioning. Four electronic databases (MEDLINE - Ovid, Embase CINAHL, PsycINFO) were searched. All experimental, quasi-experimental pre-experimental studies included, provided they: (a) published English; (b) recruited insomnia; (c) used sleep restriction and/or stimulus control; (d) reported outcomes pre-and-post intervention. Database searches returned 1689 articles; 15 studies, summarising results 498 included three focused control, four restriction, eight adopted multicomponent treatments comprised both interventions. brought about significant improvements one or subjectively measured facets although, overall, therapies demonstrated larger effects (median Hedge's g = 0.55). Actigraphic polysomnographic smaller no effects. Improvements measures depression seen interventions, but intervention any statistically improvement anxiety. corroborates existing consensus that approaches confer most benefit, adds by demonstrating this be case brief, guides future study populations where cognitive not appropriate.

Language: Английский

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